A5087080313- Cancer-related molecular mechanisms research
- Byzantine Studies and History
- Circular RNAs in diseases
- Nietzsche, Schopenhauer, and Hegel
- RNA modifications and cancer
- Medieval History and Crusades
- Religion, Society, and Development
- Historical and Archaeological Studies
- Christian Theology and Mission
- MicroRNA in disease regulation
- Eurasian Exchange Networks
- Historical and Architectural Studies
- COVID-19 Clinical Research Studies
- Cardiac Structural Anomalies and Repair
- Historical and Religious Studies of Rome
- RNA Research and Splicing
- Congenital heart defects research
- Phagocytosis and Immune Regulation
- Ancient Mediterranean Archaeology and History
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Critical Theory and Philosophy
- Cardiac pacing and defibrillation studies
- Religious Tourism and Spaces
- Zebrafish Biomedical Research Applications
University of Edinburgh
2019-2025
The Queen's Medical Research Institute
2019-2025
MAST Carbon (United Kingdom)
2024
University of Essex
2014-2021
University of Winchester
2017
Hochschul Informations System
2016
Icahn School of Medicine at Mount Sinai
2016
Centre Hospitalier Universitaire de Grenoble
2016
Schwarzwald-Baar Klinikum
2016
National Institute for Medical Research
2014
[Figure: see text].
Abstract Aims Coronary vasculature formation is a critical event during cardiac development, essential for heart function throughout perinatal and adult life. However, current understanding of coronary vascular development has largely been derived from transgenic mouse models. The aim this study was to characterize the transcriptome human foetal endothelium using single-cell RNA sequencing (scRNA-seq) provide new insights into cellular heterogeneity transcriptional dynamics that underpin...
Activation of vascular smooth muscle cell (VSMC) inflammation is vital to initiate disease. The role human-specific long noncoding RNAs in VSMC poorly understood.
Background— Leadless cardiac pacemakers have emerged as a safe and effective alternative to conventional transvenous single-chamber ventricular pacemakers. Herein, we report multicenter experience on the feasibility safety of acute retrieval (<6 weeks) chronic (>6 leadless pacemaker in humans. Methods Results— This study included patients enrolled 3 trials, who received implant subsequently underwent device removal attempt. The overall success rate was 94%: for whose had been implanted...
Adiponectin is the most abundant hormone in circulation. Plasma adiponectin decreases obesity but increases leanness, including during caloric restriction (CR) animals and humans. In obesity, deficiency promotes cardiometabolic dysfunction. contrast, roles of CR, when it at its highest, are largely unknown. To address this, we studied global knockout (KO) male female mice fed either ad libitum (AL) or a 30% CR diet from 9-13 weeks age. We show that KO did not alter effects on body mass,...
Abstract Aims The highly conserved long non-coding RNA (lncRNA) MIR505HG has been primarily recognized as a precursor for microRNAs (miR)-424 and miR-503. However, studies have since demonstrated that MIR503HG distinct functions from its associated miRNAs, playing important roles in cell proliferation, invasion, apoptosis, differentiation. While these miRNAs are known to influence cardiomyocyte differentiation, the specific role of heart development remains unexplored. We seek determine how...
Extracellular vesicles (EVs) released from healthy endothelial cells (ECs) have shown potential for promoting angiogenesis, but their therapeutic efficacy remains poorly understood. We previously that transplantation of a human embryonic stem cell-derived cell product (hESC-ECP), promotes new vessel formation in acute ischemic disease mice, likely via paracrine mechanism(s). Here, we demonstrated EVs hESC-ECPs (hESC-eEVs) significantly increased EC tube and wound closure vitro at ultralow...
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect multiple organ systems, including the pulmonary vasculature. Endothelial cells (ECs) are thought to play a key role in propagation of COVID-19, however, our understanding exact scale dysregulation sustained microvasculature (pMV) remains incomplete. Here we aim identify transcriptional, phenotypic, and functional changes within pMV induced COVID-19. Human microvascular endothelial (HPMVEC) treated with...
ABSTRACT Proliferation of vascular smooth muscle cells (vSMCs) following injury is a crucial contributor to pathological remodelling. MicroRNAs (miRNAs) are powerful gene regulators and attractive therapeutic agents. Here, we aim systematically identify characterise miRNAs with potential in targeting aberrant vSMC proliferation. We performed high-throughput vitro screen using library 2042 human miRNA-mimics for their impact on proliferation identified seven novel antiproliferative i.e...
Vascular smooth muscle cells (VSMCs) provide vital contractile force within blood vessel walls, yet can also propagate cardiovascular pathologies through proliferative and pro-inflammatory activities. Such phenotypes are driven, in part, by the diverse effects of long non-coding RNAs (lncRNAs) on gene expression. However, lncRNA characterisation VSMCs pathological states is hampered incomplete representation reference annotation. We aimed to improve such contexts assembling non-reference...
Loop-mediated isothermal amplification (LAMP) is a cost-effective, rapid, and highly specific method of replicating nucleic acids. Adding multiple targets into single LAMP assay to create multiplex format desirable for clinical applications but has been challenging due need develop detection techniques strict primer design criteria. This study describes the evaluation rapid triplex assay, MAST ISOPLEX® VTEC, simultaneous Shiga toxin/verotoxin 1 2 (stx1/vt1 stx2/vt2) genes in verotoxigenic...
I would venture that there are few greater opportunities for interesting comparative work in the history of philosophy than granted by Hegel and Nietzsche. This is largely due to fact any careful consideration two will eventually lead questions about nature itself. Both Nietzsche were profoundly concerned with role influence legacy thought could play identity a thinker (her “world-historical significance”), and, perhaps more importantly, both heavily preoccupied understanding difference,...
Cardiomyocyte proliferation gradually declines during embryogenesis resulting in severely limited regenerative capacities the adult heart. Understanding developmental processes controlling cardiomyocyte may thus identify new therapeutic targets to modulate cell cycle activity of cardiomyocytes In present study, we investigate mechanism by which FGF10 controls fetal and test hypothesis that promotes proliferative capacity cardiomyocytes. Analysis Fgf10-/- hearts primary cultures reveals...
Activation of vascular smooth muscle cells (VSMCs) inflammation is vital to initiate disease. However, the role human-specific long noncoding RNAs (lncRNAs) in VSMC poorly understood.Bulk RNA-seq differentiated human VSMCs revealed a novel lncRNA called IN flammatory M K L1 I nteracting L ong N oncoding RNA ( INKILN ). expression was assessed multiple vitro and ex vivo models phenotypic modulation atherosclerosis abdominal aortic aneurysm (AAA) samples. The transcriptional regulation...
Introduction and Aims: While primarily a pulmonary disease, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect multiple organ systems, including the vasculature. Thus far studies have successfully characterised whole compartment, however, our understanding of mechanisms associated with COVID-19 infection its impact on microvasculature (pMV) remains incomplete. In human microvascular endothelial cells (HPMVEC) treated plasma from patients hospitalised COVID-19, we aimed...
Background: COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect multiple organ systems, including the pulmonary vasculature. Endothelial cells (ECs) are thought to play a key role in propagation of COVID-19, however, our understanding exact scale dysregulation sustained microvasculature (pMV) remains incomplete. Here we aim identify transcriptional, phenotypic, and functional changes within pMV induced COVID-19.Methods Results: Human microvascular...