A5055961944- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Adipose Tissue and Metabolism
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Retinopathy of Prematurity Studies
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Antimicrobial Peptides and Activities
- Dietary Effects on Health
- Ocular Diseases and Behçet’s Syndrome
- Fatty Acid Research and Health
- Birth, Development, and Health
- Ophthalmology and Visual Impairment Studies
- Psychoanalysis and Psychopathology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Probiotics and Fermented Foods
- Historical and Scientific Studies
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Protein Hydrolysis and Bioactive Peptides
- Electrospun Nanofibers in Biomedical Applications
- Child Abuse and Related Trauma
- Traumatic Ocular and Foreign Body Injuries
LMU Klinikum
2025
Ludwig-Maximilians-Universität München
2025
University of Edinburgh
2019-2024
The Queen's Medical Research Institute
2019-2024
Inserm
2024
Klinikum Ludwigshafen
2024
Heidelberg University
2023-2024
Bayer (Germany)
2024
Université de Rouen Normandie
2024
Ludwigshafen University of Business and Society
2023
Abstract Bone marrow adipose tissue (BMAT) comprises >10% of total mass, yet unlike white or brown tissues (WAT BAT) its metabolic functions remain unclear. Herein, we address this critical gap in knowledge. Our transcriptomic analyses revealed that BMAT is distinct from WAT and BAT, with altered glucose metabolism decreased insulin responsiveness. We therefore tested these mice humans using positron emission tomography-computed tomography (PET/CT) 18 F-fluorodeoxyglucose. This resists...
Caloric restriction (CR) reduces the risk of age-related diseases in numerous species, including humans. CR's metabolic effects, decreased adiposity and improved insulin sensitivity, are important for its broader health benefits; however, extent basis sex differences benefits unknown. We found that 30% CR young (3-month-old) male mice fat mass glucose tolerance whereas these effects were blunted or absent females. Females' resistance to loss was associated with lipolysis, energy expenditure...
Fibrovascular contraction and tractional retinal detachment (TRD) are recognized complications associated with the use of anti-vascular endothelial growth factor agents in vasoproliferative vitreoretinopathies. The authors characterize TRDs that developed after intravitreal bevacizumab or ranibizumab therapy for vascularly active retinopathy prematurity.This is an international, multicenter, interventional, retrospective, case series. Thirty-five eyes from 23 infants were included. Inclusion...
Adiponectin is the most abundant hormone in circulation. Plasma adiponectin decreases obesity but increases leanness, including during caloric restriction (CR) animals and humans. In obesity, deficiency promotes cardiometabolic dysfunction. contrast, roles of CR, when it at its highest, are largely unknown. To address this, we studied global knockout (KO) male female mice fed either ad libitum (AL) or a 30% CR diet from 9-13 weeks age. We show that KO did not alter effects on body mass,...
BACKGROUND AND OBJECTIVE: The authors report the technique of using 27-gauge (G) vitreous cutter through 25-G valved cannulas to allow hybrid instrumentation both gauges. PATIENTS METHODS: Vitrectomy is initiated with standard placement cannulas, followed by insertion a 27-G cannulas. RESULTS: procedure emphasizes advantages platforms: more efficient for core vitrectomy and rigid facilitate peripheral vitrectomy; platform enjoys wider armamentarium options; smaller profile can be maneuvered...
Purpose: The aim of the study was to present long-term anatomical and visual outcomes retinal detachment repair in patients with Stickler syndrome. Patients methods: This is a retrospective, interventional, consecutive case series syndrome undergoing reattachment surgery from 2009 2014 at Associated Retinal Consultants, William Beaumont Hospital. Results: Sixteen eyes 13 were identified. underwent mean 3.1 surgical interventions (range: 1–13) postoperative follow-up 94 months 5–313 months)....
Immunoglobulins (Ig) reactive with α-melanocyte-stimulating hormone (α-MSH), an anorexigenic neuropeptide, are present in humans and were previously associated eating disorders. In this longitudinal study involving patients anorexia nervosa (AN), we determined whether α-MSH serum is bound to IgG analyzed long-term dynamics of both peptide α-MSH-reactive Ig relation changes BMI gut microbiota composition.
To report clinical characteristics and early postoperative outcomes of pediatric cataract surgery with intraocular lens (IOL) implantation from Lahan, Nepal.Demographics surgical, preoperative, data were collected analyzed.Of 2,633 eyes primary IOL implantation, 2,003 in the non-traumatic group, whereas 630 trauma. Median age at was 7 9 years traumatic groups, respectively. Boys comprised 74.2% 85.4% patients. Unilateral cataracts accounted for only 7.7% (154 2,003) group. Average follow-up...
Purpose: To evaluate the efficacy of a dexamethasone intravitreal implant in combination with anti-vascular endothelial growth factor (VEGF) agents for treatment-resistant neovascular age-related macular degeneration (nvAMD). Methods: This study was designed as single-center, retrospective interventional case series. Consecutive patients nvAMD underwent simultaneous combined injection anti-VEGF agent and implant. Eighteen mean age 81.5 years were included. Patients received an average 26.3...
To describe wide-field imaging features of patients with congenital X-linked retinoschisis.This is a retrospective nonconsecutive series 36 eyes from 18 retinoschisis 2008 to 2014. Wide-field color fundus photographs, optical coherence tomography images, and fluorescein angiography images were reviewed. Patients classified have either exudative or nonexudative based on the presence absence lipid exudates.Eleven exhibited (30%), whereas remaining nonexudative. Exudative disease occurred more...
Abstract Background The classical functions of the skeleton encompass locomotion, protection and mineral homeostasis. However, cell-specific gene deletions in mouse human genetic studies have identified as a key endocrine regulator metabolism. bone-specific phosphatase, Phosphatase, Orphan 1 (PHOSPHO1), which is indispensable for bone mineralisation, has been recently implicated regulation energy metabolism humans, but its role systemic remains unclear. Here, we probe mechanism underlying...
Abstract Background The rise of microbial antibiotic resistance is a leading threat to the health human population. As such, finding new approaches tackle these microbes, including development novel antibiotics vital. Results In this study, we mined rumen eukaryotic metatranscriptomic library for Antimicrobial peptides (AMPs) using computational and thereafter characterised therapeutic potential AMPs. We identified total 208 potentially AMPs from ruminal eukaryotome, one those, namely...
Intravitreal corticosteroids may accelerate the normalization of macular morphology after vitrectomy and epiretinal membrane (ERM) peeling. The authors compared visual anatomic outcomes eyes undergoing this procedure with intraoperative use dexamethasone intravitreal implant (DEX) (Ozurdex; Allergan, Irvine, CA) versus triamcinolone acetonide (IVTA) (Triesence; Alcon, Fort Worth, TX).Interventional, retrospective, consecutive, case-control study.Fifty-five participants were included (DEX =...
To report on the feasibility of 27-gauge (G) vitrectomy for pediatric patients.This study is an international, multicenter, retrospective, interventional case series. Participants were patients 17 years or younger who underwent 27-G various indications.The records 56 eyes from 47 reviewed. Mean age was 5.7 ± 5.2 years. Diagnoses included retinopathy prematurity (Stages 3 with vitreous hemorrhage, 4A, 4B, and 5), Terson's syndrome, traumatic macular hole, posterior capsular opacification,...
Choroidal thickness (CT) measurements from eyes with similar areas of macular geographic atrophy (GA) secondary to age-related degeneration (AMD) and Stargardt disease (STGD) were compared determine whether GA different diseases had a or effect on the underlying subfoveal choroid.Eyes diagnosis central STGD AMD matched, CT obtained B-scan using an enhanced depth imaging protocol. The area was measured fundus autofluorescence (FAF) imaging. divided into those without reticular pseudodrusen.A...
Shah, Aparna A. MD; Thomas, Benjamin J. Yonekawa, Yoshihiro Capone, Antonio Jr MDEditor(s): Williams, George Author Information
To compare the effects of intravitreal ranibizumab (RZB) or dexamethasone (DEX) implant in cases recalcitrant diabetic macular edema (DME).Retrospective, interventional study examining patients with symmetric bilateral, center-involved DME to treatment RZB, who received DEX one eye while contralateral continued receive RZB every 4-5 weeks for a period 3 months.Eleven (22 eyes) were included: mean logarithm minimal angle resolution (logMAR) visual acuity (VA) arm improved from 0.415 (standard...
To report a novel presentation of dyskeratosis congenita masquerading as familial exudative vitreoretinopathy.Observational case series involving single family and literature review.A brother sister were diagnosed with vitreoretinopathy at ages 4 2, respectively. Both patients managed laser photocoagulation. Eight years after the initial presentation, both siblings developed pancytopenia secondary to bone marrow failure. Laboratory work-up revealed severely shortened telomere length in...
To describe the long-term anatomical and visual outcomes of a patient with retinopathy prematurity characterized by prominent retinal fold adherent to posterior lens capsule, treated lens-sparing vitrectomy surgical transection retrolental membrane.A premature infant was born at gestational age 25 weeks birthweight 636 g. She developed threshold bilaterally subsequently laser ablative therapy. The left eye responded favorably, regression neovascularization; however, right progressed Stage 4A...