A5012602381- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Drug-Induced Ocular Toxicity
- Neuroscience and Neural Engineering
- Mitochondrial Function and Pathology
- Intraocular Surgery and Lenses
- CRISPR and Genetic Engineering
- Retinal and Macular Surgery
- Retinopathy of Prematurity Studies
- Intraoperative Neuromonitoring and Anesthetic Effects
- Ocular Oncology and Treatments
- Health disparities and outcomes
- Connexins and lens biology
- Photoreceptor and optogenetics research
- Visual perception and processing mechanisms
- Ophthalmology and Eye Disorders
- RNA regulation and disease
- Health Systems, Economic Evaluations, Quality of Life
- Virus-based gene therapy research
University of Miami
2016-2025
Miami Dermatology and Laser Institute
2013-2024
University of Pennsylvania
2023
University of Miami Health System
2018-2023
Penn Presbyterian Medical Center
2023
Impact
2023
Creative Commons
2021
Biogen (United States)
2021
Prevent Blindness
2012-2021
Ghent University Hospital
2021
<h3>Importance</h3> Worsening vision and declining cognitive functioning are common conditions among elderly individuals. Understanding the association between them could be beneficial in mitigating age-related changes. <h3>Objective</h3> To evaluate longitudinal associations visual impairment function over time a population-based study of older US adults. <h3>Design, Setting, Participants</h3> Prospective adults greater Salisbury area Maryland. Overall, 2520 community-residing aged 65 to 84...
Recent studies suggest that maintenance intravenous immunoglobulin (IVIG) may be an effective treatment to prevent relapses in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); however, most of these had pediatric cohorts, and few have evaluated IVIG adult patients.To determine the association with prevention relapse a large cohort patients MOGAD.This was retrospective study conducted from January 1, 2010, October 31, 2021. Patients were recruited 14 hospitals 9...
Bardet–Biedl syndrome (BBS) is a genetically heterogeneous autosomal recessive disorder with the primary clinical features of obesity, pigmented retinopathy, polydactyly, hypogenitalism, mental retardation and renal anomalies. Associated include diabetes mellitus, hypertension congenital heart disease. There are six known BBS loci, mapping to chromosomes 2, 3, 11, 15, 16 20. The BBS2 locus was initially mapped an 18 cM interval on chromosome 16q21 large inbred Bedouin kindred. Further...
Mutations in ABCA4 cause Stargardt disease and other blinding autosomal recessive retinal disorders. However, sequencing of the complete coding sequence patients with clinical features sometimes fails to detect one or both mutations. For example, among 208 individuals clear evidence ascertained at a single institution, 28 had only disease-causing allele identified exons splice junctions primary transcript gene. Haplotype analysis these probands revealed 3 haplotypes shared ten families,...
Background: The goal of the present study was to analyze macular microvacular network in mild cognitive impirment (MCI) and Alzheimer disease (AD). Methods: Twelve patients with AD 19 MCI were recruited together 21 cognitively normal controls a similar range ages. Optical coherence tomography angiography used image retinal microvascular at region, including vascular (RVN), superficial plexus (SVP), deep (DVP). Fractal analysis (box counting, D box ) representing density performed different...
IMPORTANCEThe use of a nonmydriatic camera for retinal imaging combined with the remote evaluation images at telemedicine reading center has been advanced as strategy diabetic retinopathy (DR) screening, particularly among patients diabetes mellitus from ethnic/racial minority populations low utilization eye care.OBJECTIVE To examine rate and types DR identified through screening program using camera, well other ocular findings. DESIGN, SETTING, AND PARTICIPANTSA cross-sectional study...
Purpose: Congenital achromatopsia (ACHM) is an autosomal recessive disorder in which cone function absent or severely reduced. Gene therapy animal models of ACHM have shown restoration function, though translation these results to humans relies, part, on the presence viable photoreceptors at time treatment. Here, we characterized residual structure subjects with CNGB3-associated ACHM. Methods: High-resolution imaging (optical coherence tomography [OCT] and adaptive optics scanning light...
The study purpose was to examine vision-specific and overall health-related quality of life (QOL) at baseline in Idiopathic Intracranial Hypertension Treatment Trial patients who were newly diagnosed had mild visual loss. We also sought determine the associations between QOL scores symptoms, function, pain, headache-related disability, obesity.
Background Understanding patterns of multimorbidity in the US older adult population and their relationship with mortality is important for reducing healthcare utilization improving health. Previous investigations measured as counts conditions rather than specific combination conditions. Methods This cross-sectional study longitudinal follow-up employed latent class analysis (LCA) to develop clinically meaningful subgroups participants aged 50 different combinations 13 chronic from National...
Importance X-linked retinitis pigmentosa (XLRP) is a severe cause of early-onset RP in male individuals, characterized by degeneration photoreceptors, an extinguished electroretinogram, and vision loss. Objective To assess the duration improvements retinal sensitivity associated with single, subretinal injection cotoretigene toliparvovec (BIIB112/AAV8-RPGR) gene therapy after vitrectomy surgery dosed eye over 12 months part 1 Clinical Trial Retinal Gene Therapy for Retinitis Pigmentosa Using...
Choroideremia is a rare, X-linked retinal degeneration resulting in progressive vision loss. A randomized, masked, phase 3 clinical trial evaluated the safety and efficacy over 12 months of follow-up adult males with choroideremia randomized to receive high-dose (1.0 × 1011 vector genomes (vg); n = 69) or low-dose 1010 vg; 34) subretinal injection AAV2-vector-based gene therapy timrepigene emparvovec versus non-treated control (n 66). Most treatment-emergent adverse events were mild...
To estimate prevalence and correlates of eye care utilization by means data from the National Health Interview Survey.
<h3>Importance</h3> Determination of the mechanisms by which visual loss increases mortality risk is important for developing interventional strategies. <h3>Objective</h3> To evaluate direct and indirect effects acuity (VA) on through functional status changes among aging adults. <h3>Design, Setting, Participants</h3> Prospective longitudinal study a population-based sample 2520 noninstitutionalized adults aged 65 to 84 years from September 16, 1993, July 26, 2003, in greater Salisbury area...
IMPORTANCE Establishing the natural history of G11778A Leber hereditary optic neuropathy (LHON) is important to determine optimal end points assess safety and efficacy a planned gene therapy trial. OBJECTIVE To use results present study patients with LHON plan clinical trial that will allotopic expression by delivering normal nuclear-encoded ND4 into nuclei retinal ganglion cells via an adeno-associated virus vector injected vitreous. DESIGN, SETTING, AND PARTICIPANTS A prospective...