A5072595366- Cerebral Venous Sinus Thrombosis
- Glaucoma and retinal disorders
- Migraine and Headache Studies
- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Olfactory and Sensory Function Studies
- Trigeminal Neuralgia and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Intraoperative Neuromonitoring and Anesthetic Effects
- Mitochondrial Function and Pathology
- Circadian rhythm and melatonin
- Drug-Induced Ocular Toxicity
- Photoreceptor and optogenetics research
- Traumatic Brain Injury and Neurovascular Disturbances
- Vasculitis and related conditions
- Neurosurgical Procedures and Complications
- Ocular Surface and Contact Lens
- Intracranial Aneurysms: Treatment and Complications
- Retinal Imaging and Analysis
- ATP Synthase and ATPases Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Otitis Media and Relapsing Polychondritis
University of Utah
2015-2025
T-Mobile (United States)
2025
University of Utah Health Care
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
University of Utah Hospital
2021
Utah System of Higher Education
2020
The University of Sydney
2016-2018
Sydney Hospital
2018
University of Calgary
2018
Making an accurate diagnosis of optic disc drusen (ODD) is important as part the work-up for possible life-threatening edema. It also to follow slowly progressive visual field defects many patients with ODD experience. The introduction enhanced depth imaging optical coherence tomography (EDI-OCT) has improved visualization more deeply buried ODD. There is, however, no consensus regarding using OCT. purpose this study was develop a recommendation diagnosing OCT.The members Optic Disc Drusen...
Objective.— To compare clinical features, visual characteristics, and treatment of idiopathic intracranial hypertension patients with without papilledema. Background.— Idiopathic does not often occur This study estimates the prevalence compares characteristics Methods.— We performed a cross‐sectional analysis all diagnosed at University Utah Neuro‐Ophthalmology Unit between 1990 2003. Patient records were reviewed for presence papilledema other signs, symptoms, characteristics. Each patient...
The study purpose was to examine vision-specific and overall health-related quality of life (QOL) at baseline in Idiopathic Intracranial Hypertension Treatment Trial patients who were newly diagnosed had mild visual loss. We also sought determine the associations between QOL scores symptoms, function, pain, headache-related disability, obesity.
Background We used in vivo corneal confocal microscopy to investigate structural differences the sub‐basal nerve plexus chronic migraine patients and a normal population. validated questionnaire tests of lacrimal function determine prevalence dry eye same group patients. Activation trigeminal system is involved migraine. Corneal nociceptive sensation mediated by axons that synapse gasserian ganglion brainstem, serve nociceptive, protective, trophic functions. Noninvasive imaging possible...
<h3>Objectives:</h3> Determine potential risk factors for progressive visual field loss in the Idiopathic Intracranial Hypertension Treatment Trial, a randomized placebo-controlled trial of acetazolamide patients with idiopathic intracranial hypertension and mild concurrently receiving low sodium, weight reduction diet. <h3>Methods:</h3> Logistic regression classification tree analyses were used to evaluate protocol-defined treatment failure (>2 dB perimetric mean deviation [PMD] change...
Retina and retinal pigment epithelium (RPE) belong to the metabolically most active tissues in human body. Efficient removal of acid load from retina RPE is a critical function mediated by choriocapillaris. However, mechanism which pH homeostasis maintained largely unknown. Here, we show that functional complex carbonic anhydrase 4 (CA4) Na+/bicarbonate co-transporter 1 (NBC1) specifically expressed choriocapillaris missense mutations CA4 linked autosomal dominant rod–cone dystrophy disrupt...
Background: Several studies have implicated vitamin A-related compounds in the pathogenesis of idiopathic intracranial hypertension (IIH). The goal this study was to compare cerebrospinal fluid (CSF) and serum concentrations retinol retinol-binding protein (RBP) subjects with without IIH. Methods: CSF samples were collected from 87 subjects. population composed IIH (IIH group, n = 28), non-IIH neurologic conditions (neurology controls, 42), undergoing preoperative lumbar puncture but no...
Inoculation of mice with herpes simplex virus types 1 and 2 (HSV-1 HSV-2) by the vaginal route resulted in viral shedding during acute phase infection development a latent vaginouterine tissue lasting up to one year greater than 25% animals. Immunization either serotype HSV markedly reduced when animals were subsequently challenged homologous serotype, but immunization HSV-2 was significantly less effective preventing after challenge HSV-1.
Most patients with migraine report photophobia associated headache; a subset interictal photophobia. These are light sensitive even during headache-free periods. The objective of this case-control study was to assess the prevalence symptoms anxiety and depression in without photophobia.We recruited 16 subjects photophobia, age- gender-matched gender- matched controls. Migraine met International Headache Society classification criteria. Participants completed questionnaire, Beck Depression...
Giant cell arteritis can have protean manifestations, many of them non-specific. We describe a patient whose initial presentation was most consistent with brainstem stroke, but who ultimately diagnosed and treated for giant arteritis. A 76-year-old woman presented abrupt onset diplopia, headache, nausea vomiting. On to the emergency department, she stroke tissue plasminogen activator. When her symptoms did not remit, closer inspection imaging revealed enhancement within orbits superficial...
Purpose: We evaluated the safety and bioactivity of carboxyamidotriazole (CAI) using two approaches, a polymeric CAI-PLGA nanoemulsion in mouse model choroidal neovascularization (CNV) CAI-loaded bioresorbable intravitreal implant rabbit vascular leakage. Methods: Mice underwent laser rupture Bruch's membrane to induce CNV followed by single (2 µL volume) injection either vehicle (n = 11); CAI nanoparticles (0.5 µg, 1 2 400 nM, 800 1.6 µM, respectively); aflibercept 10 µg; or (1 µg) + µg....
Exfoliation glaucoma (XFG) is the commonest identifiable cause of secondary open-angle worldwide, characterized by deposition fibrillar proteins in anterior segment eye. We investigated LOXL1 gene variants previously identified to confer susceptibility exfoliation a Utah Caucasian cohort. After standard eye examination protocol we genotyped SNPs rs2165241 and rs3825942 62 XFG or XFS patients 170 normal controls. Genotype frequency distribution, odds ratios (ORs), population attributable...