A5087696598- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Cytomegalovirus and herpesvirus research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Heart Rate Variability and Autonomic Control
- Neurological Complications and Syndromes
- Cardiovascular Disease and Adiposity
- Pharmacological Effects and Toxicity Studies
- Atherosclerosis and Cardiovascular Diseases
- Bone and Joint Diseases
- Mosquito-borne diseases and control
- Diet and metabolism studies
- Multiple Sclerosis Research Studies
- Ocular Diseases and Behçet’s Syndrome
- Nanocluster Synthesis and Applications
- Vitamin D Research Studies
- Parasitic infections in humans and animals
- Retinal and Optic Conditions
- Adipokines, Inflammation, and Metabolic Diseases
- Infectious Encephalopathies and Encephalitis
- Systemic Lupus Erythematosus Research
- Inflammatory Biomarkers in Disease Prognosis
University of Hawaiʻi at Mānoa
2011-2021
University of Hawaii System
1997-2019
Straub Medical Center
2008-2018
Hawaii Pacific Health
2018
AIDS United
2018
UCLA Medical Center
2017
The Lundquist Institute
2017
Harbor–UCLA Medical Center
2017
Huntington Medical Research Institutes
2013
University Memory and Aging Center
2013
Objective.— To compare clinical features, visual characteristics, and treatment of idiopathic intracranial hypertension patients with without papilledema. Background.— Idiopathic does not often occur This study estimates the prevalence compares characteristics Methods.— We performed a cross‐sectional analysis all diagnosed at University Utah Neuro‐Ophthalmology Unit between 1990 2003. Patient records were reviewed for presence papilledema other signs, symptoms, characteristics. Each patient...
High levels of human immunodeficiency virus (HIV) DNA in peripheral blood mononuclear cells (PBMCs), and specifically within CD14+ monocytes, have been found HIV-infected individuals with neurocognitive impairment dementia. The failure highly active antiretroviral therapy (HAART) to eliminate cognitive dysfunction HIV may be secondary persistence PBMCs which cross the blood-brain barrier, leading perivascular inflammation neuronal injury. This study assessed brain cortical thickness relative...
Background Monocytes transmigrating to the brain play a central role in HIV neuropathology. We hypothesized that continued existence of neurocognitive impairment (NCI) despite potent antiretroviral (ARV) therapy is mediated by inability such control this monocyte/macrophage reservoir. Methods Cross-sectional and longitudinal analyses were conducted within prospectively enrolled cohort. devised monocyte efficacy (ME) score based on anticipated effectiveness ARV medications against...
We evaluated regional brain volumes and cerebral metabolite levels as correlates of HIV DNA in peripheral blood mononuclear cells (PBMCs).In this cross-sectional study, 35 HIV+ subjects aged ≥40 years (25 with detectable PBMC DNA; 10 <10 copies/10(6) cells, the threshold detection) 12 seronegative controls underwent structural MRI magnetic resonance spectroscopy at 3 T. were on combination antiretroviral therapy ≥1 year; all but 1 had plasma RNA <50 copies/mL. used logistic regression to...
To evaluate changes in neuropsychological (NP) performance and plasma cell surface markers of peripheral monocyte activation/migration after treatment with cenicriviroc (CVC), a dual C-C chemokine receptor type 2 (CCR2) 5 (CCR5) antagonist, treatment-experienced, HIV-infected individuals.Single-arm, 24-week, open-label clinical trial.HIV-infected individuals on antiretroviral therapy ≥1 year HIV RNA ≤50 copies per milliliter below-normal cognitive [defined as age-, sex-, education-adjusted...
Chronic infection by HIV increases the risk of cardiovascular disease (CVD) despite effective antiretroviral therapy (ART). The mechanisms linking to CVD have yet be fully elucidated. High plasma levels pro-inflammatory cytokine IL-6, which may triggered IL-1β, is a biomarker in HIV-negative adults, and all-cause mortality disease. Monocytes play pivotal role atherosclerosis, major mediators HIV-associated inflammation. We therefore hypothesized that monocytes from HIV-infected adults would...
<h3>BACKGROUND AND PURPOSE:</h3> Surfing is an uncommon cause of acute nontraumatic myelopathy. This study describes the MR imaging characteristics and clinical correlates in 23 subjects with surfer9s <h3>MATERIALS METHODS:</h3> was a retrospective review cases myelopathy from 2003–2012. Spinal cord neurologic examinations use American Injury Association scale were reviewed. Logistic regression used to determine associations between characteristics, scale, improvement. <h3>RESULTS:</h3> All...
To assess the role of HIV and monocytes/macrophages in adipose tissue dysregulation.Cross-sectional study 5 groups: seronegative, HIV+ antiretroviral therapy (ART)-naive, nonlipoatrophic on zidovudine- and/or stavudine-containing ART, lipoatrophic similar abacavir- or tenofovir-containing ART. DNA circulating monocyte subsets was quantitated by real-time polymerase chain reaction. Biopsied subcutaneous fat examined for macrophage content CD68 staining. Isolated adipocytes macrophages were...
Abstract Monocytes/macrophages contribute to the neuropathogenesis of HIV-related cognitive impairment (CI); however, considerable gaps in our understanding precise mechanisms driving this relationship remain. Furthermore, whether a distinct biological profile associated with CI resides immune cell populations remains unknown. Here, we profiled DNA methylomes and transcriptomes monocytes derived from HIV-infected individuals without using genome-wide methylation gene expression profiling. We...
<h3>Importance</h3> Despite more widely accessible combination antiretroviral therapy (cART), HIV-1 infection remains a global public health challenge. Even in treated patients with chronic HIV infection, neurocognitive impairment often persists, affecting quality of life. Identifying the neuroanatomical pathways associated vivo may delineate neuropathologic processes underlying these deficits. However, published neuroimaging findings from relatively small, heterogeneous cohorts are...
Background Rates of insulin resistance are increased in HIV-infected patients on stable antiretroviral therapy (ART). Such increase may partially be due to HIV-induced immune dysregulation involving monocytes (MO) and its subsets. Materials Methods Cross-sectional analysis 141 subjects age ≥ 40 years ART. Homeostatic model assessment–insulin (HOMA-IR) rates metabolic syndrome were calculated. Subjects classified by fasting glucose oral tolerance test (OGTT) into clinical diabetes categories....
Background Persistent inflammation and immune activation has been hypothesized to contribute increased prevalence of subclinical atherosclerosis cardiovascular disease (CVD) risk in patients with chronic HIV infection. In this study, we examined the correlation peripheral monocyte subsets soluble biomarkers coronary artery calcium (CAC) progression, as measured by cardiac computed tomography scan. Methods We conducted a longitudinal analysis utilizing baseline data 78 participants infection...
<i>Background:</i> This study is designed to determine the relationship between age and occurrence of cerebral manifestations small-vessel ischemic vascular disease in human immunodeficiency virus (HIV)-seropositive individuals. <i>Methods:</i> Periventricular leukoaraiosis severity white matter lesion volume were determined by magnetic resonance imaging brain 57 HIV-seropositive <i>Results:</i> Cerebral correlated with systolic blood pressure, but not HIV...
Background: The frequency of neurocognitive impairment (NCI) in human immunodeficiency virus (HIV) -infected individuals remains high despite the availability potent antiretroviral therapy (ART). concurrence depression among HIV-infected patients with NCI is common, especially older individuals. Depression has been implicated as a risk factor for impaired neuropsychological performance (NP). This study explored relationship between depressive symptoms and NP testing Methods: A...
Purpose: HIV infection has been implicated in dysregulationofthe autonomic nervous system. Method: Cross-sectional study exam ining the relationship between presence of persistent detectable viral load with function, measured by heart rate variability (HRV). Non-virologic suppression (NVS) was defined as having a for at least 3 months prior to function testing. HRV during following 4 maneuvers: resting and paced respirations sustained handgrip tilt. Inferences on parasympathetic sympathetic...
Background: Inflammation may contribute to cardiovascular disease (CVD) among antiretrovirally suppressed HIV-infected individuals. We assessed relationships of monocyte, CD8 T-cell activation and plasma biomarkers changes in carotid artery intima-media thickness (CIMT).Methods: Longitudinal study subjects ≥40 years on stable antiretroviral therapy (ART) ≥3 months. Peripheral blood mononuclear cells were immunophenotyped by multiparameteric flow cytometry quantify classical (CD14++CD16–),...
Data on dementia in Native Hawaiians and many Asian subgroups the United States are limited. Inpatients with have higher costs, longer stays, mortality than those without dementia. This study compared rates of inpatients a diagnosis for disaggregated Pacific Islanders (Native Hawaiian, Chinese, Japanese, Filipino) whites according to age (18-59, 60-69, 70-79, 80-89, ≤90) all adults hospitalized Hawai'i between December 2006 2010; 13,465 were identified using International Classification...