A5014963573- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Retinopathy of Prematurity Studies
- Retinal and Optic Conditions
- Cosmology and Gravitation Theories
- Galaxies: Formation, Evolution, Phenomena
- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Dark Matter and Cosmic Phenomena
- Preterm Birth and Chorioamnionitis
- Black Holes and Theoretical Physics
- Circadian rhythm and melatonin
- Optical Imaging and Spectroscopy Techniques
- Advanced Fluorescence Microscopy Techniques
- Relativity and Gravitational Theory
- CRISPR and Genetic Engineering
- Neonatal and fetal brain pathology
- Visual perception and processing mechanisms
Oxford University Hospitals NHS Trust
2021-2025
University of Oxford
2021-2025
Nuffield Orthopaedic Centre
2021-2024
Oxford BioMedica (United Kingdom)
2021-2024
National Health Service
2023
University of Nottingham
2009-2011
Primordial black holes (PBHs) can form in the early Universe via collapse of large density perturbations. There are tight constraints on abundance PBHs formed due to their gravitational effects and consequences evaporation. These be used constrain primordial power spectrum, hence models inflation, scales far smaller than those probed by cosmological observations. We compile, where relevant update, before calculating curvature perturbation, taking into account growth perturbations prior...
Importance X-linked retinitis pigmentosa (XLRP) is a severe cause of early-onset RP in male individuals, characterized by degeneration photoreceptors, an extinguished electroretinogram, and vision loss. Objective To assess the duration improvements retinal sensitivity associated with single, subretinal injection cotoretigene toliparvovec (BIIB112/AAV8-RPGR) gene therapy after vitrectomy surgery dosed eye over 12 months part 1 Clinical Trial Retinal Gene Therapy for Retinitis Pigmentosa Using...
Purpose: To explore which microperimetry sensitivity index (pointwise sensitivity, mean and volume sensitivity) is suitable as a outcome measure in patients with X-linked RPGR-associated retinitis pigmentosa (RP). Methods: Microperimetry data from RP were collected analyzed retrospectively. Fourteen participants completed triplicate testing, across 2 consecutive days for the repeatability analyses. Longitudinal was obtained 13 who testing at two separate visits. Results: The test–retest...
Ultracompact minihalos (UCMHs) are dense dark matter structures, which can form from large density perturbations shortly after matter-radiation equality. If is in the of weakly interacting massive particles (WIMPs), then UCMHs may be detected via their gamma-ray emission. We investigate how Fermi satellite could constrain abundance and place limits on power spectrum primordial curvature perturbation. Detection by would put a lower limit UCMH halo fraction. The smallest detectable fraction...
Purpose: Mean retinal sensitivity is the main output measure used in microperimetry. It is, however, of limited use patients with poor vision because averaging weighted toward zero those significant scotomas creating an artificial floor effect. In contrast, volumetric measures avoid these issues and are displayed graphically as a hill vision. Methods: An open-source program was created to manipulate raw threshold data files obtained from MAIA Thin plate spline interpolated heat maps...
Purpose: To assess the rate of retinal vascularisation derived from ultra-widefield (UWF) imaging-based retinopathy prematurity (ROP) screening as predictor type 1 ROP and characterise effect anti-VEGF therapy on rate. Design: Retrospective, consecutive cohort study. Subjects: 132 eyes 76 premature infants with mean gestational age (GA) 26.0(±2.0SD) weeks birth weight (BW) 815(±264) g, who underwent longitudinal UWF imaging for screening. Setting/Venue: Level 3 neonatal unit in Oxford,...
Purpose: Microperimetry provides an accurate assessment of central retinal sensitivity due to its fundus-tracking capability, but it has limited reliability indicators. One method currently employed, fixation loss, samples the optic nerve blind spot for positive responses; however, is unclear if these responses arise from unintentional button presses or tracking failure leading stimuli misplacement. We investigated relationship between scotoma (termed responses) and fixation. Methods: Part 1...
Purpose: In patients with choroideremia, it is not known how smooth and mottled patterns on short-wavelength fundus autofluorescence (AF) imaging relate to retinal function. Methods: A retrospective case-note review was undertaken 190 choroideremia at two specialist centers for genetics. Twenty both zones AF concurrent mesopic microperimetry assessments were included. Mean sensitivities within the compared between patients, identical points collected from 12 age-matched controls....
Introduction: Choroideremia and RPGR-associated retinitis pigmentosa (RP) are two distinct inherited rod-cone degenerations, where good visual acuity (VA) is maintained until late disease stages, limiting its usefulness as a marker. Low luminance VA low deficit (standard minus VA) may be more sensitive function measures. Methods: Standard was obtained using Early Treatment Diabetic Retinopathy Study letter charts (Precision Vision, Bloomington, IL, USA). assessed 2.0-log unit neutral density...
Abstract Introduction Degeneration in choroideremia, unlike typical centripetal photoreceptor degenerations, is centred temporal to the fovea. Once fovea affected, nasal visual field (temporal retina) relatively spared, and preferred retinal locus shifts temporally. Therefore, when reading left right, only right eye reads into a scotoma. We investigate how this unique property affects ability read an chart. Methods Standard‐ low‐luminance acuity (VA) for eyes were measured with Early...
Purpose: Peripheral visual fields have not been as well defined by static automated perimetry kinetic in RPGR-related retinitis pigmentosa. This study explores the pattern and sensitivities of peripheral fields, which may provide an important end point when assessing interventional clinical trials. Methods: A retrospective observational cross-sectional 10 genetically confirmed RPGR subjects was performed. Visual were obtained using Octopus 900 perimeter. Interocular symmetry repeatability...
Primordial black hole (PBH) abundance limits constrain the primordial power spectrum, and hence models of inflation, on scales far smaller than those probed by cosmological observations. Single field inflation which are compatible with all data can have large enough perturbations small to overproduce PBHs, be excluded. The standard formulae for amplitude do not hold modes that exit horizon close end however. We use a modified flow analysis identify where is large. For these we then carry out...
Clinical trials for X-linked retinitis pigmentosa (RP) often assess retinal structure using optical coherence tomography (OCT) and function microperimetry to evaluate initial eligibility endpoints. Therefore, we seek determine which parameters might be most sensitive in screening new patients enrollment.
Purpose: Clinical trials of novel therapies for choroideremia require robust and clinically meaningful visual function outcome measures. Best-corrected acuity (BCVA) is mostly insensitive to changes in disease state, until late stages, hence also potential therapeutic gains after gene therapies. While the insensitivity BCVA as an effective measure common wisdom, its low importance has not been rigorously demonstrated literature. This work uses statistical techniques rank relative functional...
Color vision is considered a marker of cone function and its assessment in patients with retinal pathology complementary to the assessments spatial [best-corrected visual acuity (BCVA)] contrast detection (perimetry). Rod-cone chorioretinal dystrophies-such as choroideremia-typically cause alterations color vision, making potential outcome measure clinical trials. However, evaluation may be compromised by pathological changes field. The low Cambridge Test (lvCCT) was developed specifically...
Choroideremia is an X-linked outer retinal degeneration. Early symptoms include nyctalopia and progressive visual field loss, but acuity preserved until late disease stages. Dark-adapted two-color fundus-controlled perimetry (also known as scotopic microperimetry) has been developed to enable spatial assessment of rod cone photoreceptor function. This study explores the use microperimetry in patients with choroideremia.