A5008156324- Retinal Diseases and Treatments
- Retinopathy of Prematurity Studies
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Neonatal Respiratory Health Research
- Glaucoma and retinal disorders
- Cancer, Hypoxia, and Metabolism
- Neonatal and fetal brain pathology
- Ocular Oncology and Treatments
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Mitochondrial Function and Pathology
- Angiogenesis and VEGF in Cancer
- Ocular Infections and Treatments
- Child Abuse and Related Trauma
- Redox biology and oxidative stress
- Circadian rhythm and melatonin
- Neonatal Health and Biochemistry
- Connexins and lens biology
- Traumatic Ocular and Foreign Body Injuries
- Cerebral Venous Sinus Thrombosis
- Vascular Malformations Diagnosis and Treatment
- Advanced Glycation End Products research
Cleveland Eye Clinic
2016-2025
Cleveland Clinic
2016-2025
California Health and Human Services Agency
2024
San Francisco Department of Public Health
2021-2024
Washington University in St. Louis
2024
CSL (United States)
2023
Cleveland Clinic Lerner College of Medicine
2008-2022
Bayer (United States)
2016
Case Western Reserve University
2007-2014
Chicago State University
2014
purpose. To quantify and evaluate the distribution of angiotensin II (Ang II) its receptors in human retina. methods. Donor eyes were obtained within 12 hours postmortem classified as hypertensive or normotensive diabetic nondiabetic, based on donors' medical histories. Ang retina vitreous was quantified by RIA. characterized competitive membrane-binding assays. II, heptapeptide metabolite Ang-(1-7), AT1 AT2 localized immunohistochemistry confocal imaging. results. Levels significantly...
<h3>Objective</h3> To evaluate the anatomical and visual outcomes of patients treated with ocriplasmin for treatment symptomatic vitreomacular adhesion (sVMA), including traction syndrome macular holes. <h3>Design</h3> Retrospective, interventional, single centre, case series. <h3>Participants</h3> Patients sVMA. <h3>Intervention</h3> were a intravitreal injection 0.125 mg (Jetrea, Thrombogenics Inc, USA, Alcon/Novartis EU) reconstitution technique recommended by manufacturer. <h3>Main...
Retinopathy of prematurity (ROP) causes 100,000 new cases childhood blindness each year. ROP is initiated by oxygen supplementation necessary to prevent neonatal death. We used organ systems pharmacology define the transcriptomes mice that were cured oxygen-induced retinopathy (OIR, model) hypoxia-inducible factor (HIF) stabilization via HIF prolyl hydroxylase inhibition using isoquinolone Roxadustat or 2-oxoglutarate analog dimethyloxalylglycine (DMOG). Although both molecules conferred a...
<h3>Importance</h3> Several jurisdictions in the United States have secured hotels to temporarily house people experiencing homelessness who require isolation or quarantine for confirmed suspected coronavirus disease 2019 (COVID-19). To our knowledge, little is known about how these programs serve this vulnerable population outside hospital setting. <h3>Objective</h3> assess safety of a hotel-based and (I/Q) care system its association with inpatient capacity. <h3>Design, Setting,...
Choroidal neovascularization (CNV), the advanced stage of age-related macular degeneration (AMD), accounts for >80% vision loss in AMD. Carboxyethylpyrrole (CEP) protein modifications, uniquely generated from oxidation docosahexaenoate-containing lipids, are more abundant Bruch’s membrane AMD eyes. We tested hypothesis that CEP adducts stimulate angiogenesis and possibly contribute to CNV Human serum albumin (HSA) or acetyl-Gly-Lys- O -methyl ester (dipeptide) were chemically modified...
Oxygen-induced retinopathy (OIR) in the mouse, like analogous human disease of prematurity, is an ischemic dependent on oxygen-induced vascular obliteration. We tested hypothesis that chemically overriding downregulation hypoxia-inducible factor (HIF) activity would prevent obliteration and subsequent pathologic neovascularization OIR model. Because degradation HIF-1alpha regulated by prolyl hydroxylases, we examined effect systemic administration a hydroxylase inhibitor,...
It is paradoxical that although antibodies to the outer surface protein (Osp) A of Borrelia burgdorferi protect mice against infection and immunization uninfected with Osp-A protective, induced early in natural are not curative. region recognized by a neutralizing mAb also sera from chronically infected or immunized but bound for 15 days. Infection mice, despite presence antibody, may therefore be explained part lack response this epitope. Sera humans recognizes region, case immune occurs...
Acta Ophthalmol. 2010: 88: e334–e340 Abstract. Purpose: Single‐centre consecutive interventional case series by retrospective chart review to evaluate the efficacy of verteporfin (Visudyne™) photodynamic therapy (PDT) retinal capillary haemangioma (RCH). Methods: Following an initial period observation, six eyes five patients with RCH (juxtapapillary 3 and extrapapillary (EP) 3) received 1–3 sessions standard PDT upon development progressive vision‐threatening complications. Four had von...
We determined which metabolic pathways are activated by hypoxia-inducible factor 1–mediated (HIF-1–mediated) protection against oxygen-induced retinopathy (OIR) in newborn mice, the experimental correlate to of prematurity, a leading cause infant blindness. HIF-1 coordinates change from oxidative glycolytic metabolism and mediates flux through serine 1-carbon (1CM) hypoxic cancer cells. used untargeted metabolite profiling vivo demonstrate that hypoxia mimesis activates serine/1CM. Both...
To evaluate the short-term outcomes of patients with exudative neovascular age-related macular degeneration (nAMD) treated high-dose aflibercept 8.0 mg (HDA), focusing on anatomical and functional changes, as well feasibility extending treatment intervals in real-world clinical practice. Retrospective, noncomparative cohort study. 219 eyes from 184 nAMD who received at least three HDAs between August 2023 October 2024. Patients included this study were either treatment-naïve or had been...
To report acute postoperative, presumed sterile endophthalmitis following intravitreal injection of triamcinolone acetonide (IVTA).Retrospective, interventional, multicenter study patients with IVTA injection.A total 922 injections were performed. Eight eyes 8 identified. The incidence was 0.87% (95% confidence interval, 0.38% to 1.70%). Median time presentation 1.5 days (range, 1 7 days). presenting visual acuity 20/563 20/80 light perception). Initial treatment included vitreous tap and...
Abstract Quantification of microvascular remodeling as a meaningful discovery tool requires mapping and measurement site‐specific changes within vascular trees networks. Vessel density other critical parameters are often modulated by molecular regulators determined local architecture. For example, enlargement vessel diameter endothelial growth factor (VEGF) is restricted to specific generations branching (Parsons‐Wingerter et al., Microvascular Research72: 91, 2006). The averaging over many...
Purpose.: To demonstrate a novel algorithm for macular hole (MH) segmentation and volumetric analysis.
The Surfactant, Positive Pressure, and Pulse Oximetry Randomized Trial (SUPPORT) demonstrated that static low oxygen saturation decreased retinopathy of prematurity (ROP) but increased mortality compared with high cohorts.To compare outcomes a biphasic protocol targets recommended by SUPPORT.Retrospective cohort study comparing vs standards 41 months prior to 42 after change from SUPPORT at level III neonatal intensive care unit (Fairview Hospital, Cleveland, Ohio). included infants born...
purpose. To test whether triamcinolone acetonide (TA) inhibits angiogenesis induced by IL-6 or VEGF and this inhibition is through antagonism of the receptor 2. methods. A rat cornea micropocket assay was used to initiate IL-6– VEGF-mediated angiogenesis. The ability TA neutralizing antibody inhibit neovascularization analyzed measuring vessel length, extension, area. phosphorylation signal transduction activator 3 (STAT3), receptor, extracellular signal-regulated kinase 1/2 (ERK1/2)...