A5069463629- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Ocular Diseases and Behçet’s Syndrome
- Retinopathy of Prematurity Studies
- Corneal Surgery and Treatments
- Ocular Oncology and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Ocular and Foreign Body Injuries
- Cell death mechanisms and regulation
- Metabolism, Diabetes, and Cancer
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Metabolomics and Mass Spectrometry Studies
- Ophthalmology and Visual Impairment Studies
- Mitochondrial Function and Pathology
- Optical Coherence Tomography Applications
- Immune cells in cancer
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Cerebral Venous Sinus Thrombosis
Massachusetts Eye and Ear Infirmary
2016-2025
Harvard University
2016-2025
Retina Associates
2016-2024
Mass General Brigham
2021-2023
The Retina Center
2019-2021
University of Alabama at Birmingham
2019
Angiogenesis Foundation
2010-2018
Massachusetts General Hospital
1996-2017
Smith-Kettlewell Eye Research Institute
2014-2017
University of Crete
2016
The concentration of malonyl-CoA, a negative regulator fatty acid oxidation, diminishes acutely in contracting skeletal muscle. To determine how this occurs, the activity and properties acetyl-CoA carboxylase beta (ACC-beta), muscle isozyme that catalyzes malonyl-CoA formation, were examined rat gastrocnemius-soleus muscles at rest during contractions induced by electrical stimulation sciatic nerve. avoid problem contamination extract mitochondrial carboxylases, an assay was developed which...
Apoptosis has been shown to be a significant form of cell loss in many diseases. Detachment photoreceptors from the retinal pigment epithelium, as seen various disorders, causes photoreceptor and subsequent vision decline. Although caspase-dependent apoptotic pathways are activated after detachment, caspase inhibition by pan-caspase inhibitor Z-VAD fails prevent death; thus, we investigated other leading loss. Here, show that receptor interacting protein (RIP) kinase-mediated necrosis is...
Colony-stimulating factor 1 receptor (CSF1R) inhibition has been proposed as a method for microglia depletion, with the assumption that it does not affect peripheral immune cells. Here, we show CSF1R by PLX5622 indeed affects myeloid and lymphoid compartments, causes long-term changes in bone marrow-derived macrophages suppressing interleukin 1β, CD68, phagocytosis but CD208, following exposure to endotoxin, also reduces population of resident interstitial peritoneum, lung, liver spleen....
The small GTP-binding protein Ras is pivotal in transmitting growth and differentiation signals downstream of cell surface receptors. Many observations have indicated that transmits from receptors into multiple pathways via direct interaction with different effectors mammalian cells. We identified a novel potential effector or target named Nore1. Nore1 has no significant sequence similarity to known proteins lacks an identifiable catalytic domain, but contains motifs predict DAG_PE binding...
Background Visual loss in glaucoma is associated with pathological changes retinal ganglion cell (RGC) axons and a slow decline the RGC population. Age elevated intraocular pressure (IOP) are main risk factors for glaucomatous of vision. Several studies have implicated proinflammatory cytokine tumor necrosis factor- α (TNF-α) as link between IOP death, but cellular source TNF-α its causative role death remain uncertain. Here, using rat model glaucoma, we investigated TNF- examined whether...
Retinitis pigmentosa comprises a group of inherited retinal photoreceptor degenerations that lead to progressive loss vision. Although in most cases rods, but not cones, harbor the deleterious gene mutations, cones do die this disease, usually after main phase rod cell loss. Rod death is characterized by apoptotic features. In contrast, mechanisms and features subsequent nonautonomous cone remain largely unknown. study, we show receptor-interacting protein (RIP) kinase mediates necrotic rd10...
Age-related macular degeneration (AMD) remains the leading cause of blindness in developed countries, and affects more than 150 million worldwide. Despite effective anti-angiogenic therapies for less prevalent neovascular form AMD, treatments are lacking dry form. Similarities risk factors pathogenesis between AMD atherosclerosis have led investigators to study effects statins on incidence progression with mixed results. A limitation these studies has been heterogeneity disease lack...
To compare widefield swept-source optical coherence tomography angiography (WF SS-OCTA) with ultra-widefield colour fundus photography (UWF CFP) and fluorescein FA) for detecting diabetic retinopathy (DR) lesions.This prospective, observational study was conducted at Massachusetts Eye Ear from December 2018 to October 2019. Proliferative DR, non-proliferative DR patients no were included. All imaged a WF SS-OCTA using Montage 15×15 mm scan. UWF CFP FA taken by 200°, single capture retinal...
Abstract Purpose: To evaluate available rationale and outcomes of randomized trial results for complement inhibition geographic atrophy. Methods: Data from recently completed trials inhibition, particularly pegcetacoplan avacincaptad pegol, were evaluated both the outcome, area autofluorescence loss, functional vision tests. Results: Pegcetacoplan 2 mg showed statistically significant reduction in expansion loss with monthly, but not every-other-month dosing, a 12-month phase trial. Nearly...