A5031652060- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Optical Coherence Tomography Applications
- Cerebrovascular and Carotid Artery Diseases
- Ophthalmology and Visual Impairment Studies
- Optical Imaging and Spectroscopy Techniques
- Circadian rhythm and melatonin
- Vasculitis and related conditions
- Renal and Vascular Pathologies
- Coronary Interventions and Diagnostics
- Metabolomics and Mass Spectrometry Studies
- COVID-19 and healthcare impacts
- Peripheral Artery Disease Management
- Ocular Diseases and Behçet’s Syndrome
- Traumatic Ocular and Foreign Body Injuries
- RNA and protein synthesis mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Facial Trauma and Fracture Management
- Intraocular Surgery and Lenses
- Ocular Oncology and Treatments
- Telemedicine and Telehealth Implementation
- Retinal Development and Disorders
Harvard University
2019-2025
Massachusetts Eye and Ear Infirmary
2019-2024
The Retina Center
2020-2021
University of Rochester Medical Center
2018
To compare widefield swept-source optical coherence tomography angiography (WF SS-OCTA) with ultra-widefield colour fundus photography (UWF CFP) and fluorescein FA) for detecting diabetic retinopathy (DR) lesions.This prospective, observational study was conducted at Massachusetts Eye Ear from December 2018 to October 2019. Proliferative DR, non-proliferative DR patients no were included. All imaged a WF SS-OCTA using Montage 15×15 mm scan. UWF CFP FA taken by 200°, single capture retinal...
To analyze imaging artifacts and segmentation errors with wide-field swept-source optical coherence tomography angiography (SS-OCTA) in diabetic retinopathy (DR).We conducted a prospective, observational study at Massachusetts Eye Ear from December 2018 to March 2019. Proliferative (PDR), nonproliferative (NPDR), patients no (DR), healthy control eyes were included. All imaged SS-OCTA the Montage Angio (15 × 9 mm) was used for analysis. Images independently evaluated by two graders using...
Introduction Contrast sensitivity function (CSF) may better estimate a patient’s visual compared with acuity (VA). Our study evaluates the quick CSF (qCSF) method to measure in eyes macular disease and good letter acuity. Methods Patients maculopathies (retinal vein occlusion, macula-off retinal detachment, dry age-related degeneration wet degeneration) (VA ≥20/30) were included. The qCSF uses an intelligent algorithm across multiple spatial frequencies. All maculopathy combined individual...
To study the wider field swept-source optical coherence tomography angiography (WF SS-OCTA) metrics, especially non-perfusion area (NPA), in diagnosing and staging of DR.Cross-sectional observational (November 2018-September 2020).473 eyes 286 patients (69 49 control 404 237 diabetic patients).We imaged using 6mm×6mm 12mm×12mm angiograms on WF SS-OCTA. Images were analyzed ARI Network FIJI ImageJ. Mixed effects multiple regression models receiver operator characteristic analysis was used for...
Background/aims To investigate the association between plasma metabolomic profiles and treatment response after intravitreal anti-vascular endothelial growth factor (VEGF) injections in treatment-naïve neovascular age-related macular degeneration (nAMD). Methods This is part of a prospective longitudinal study that included patients with nAMD who have undergone three loading anti-VEGF injections. All underwent ophthalmological examinations including spectral domain optical coherence...
Background/aims Pathological myopia (PM) is a leading cause of blindness worldwide. We aimed to evaluate microvascular and chorioretinal changes in different stages with wide-field (WF) swept-source (SS) optical coherence tomography angiography (OCTA). Methods This prospective cross-sectional observational study included 186 eyes 122 patients who had undergone imaging between November 2018 October 2020. Vessel density (VD) vessel skeletonised (VSD) superficial capillary plexus, deep plexus...
Purpose: To evaluate the association between contrast sensitivity (CS) and central subfield thickness (CST) in diabetic macular edema (DME). Methods: This prospectively recruited, cross-sectional study included eyes with DME evaluated from November 2018 to March 2021. CST was measured using spectral-domain optical coherence tomography on same day as CS testing. Only center-involving (CST >305 µm for women; >320 men) were included. quantitative function (qCSF) test. Outcomes visual...
Abstract Background Retinovascular changes are reported on fundus imaging in schizophrenia (SZ). This is the first study to use swept-source optical coherence tomography angiography (OCT-A) comprehensively examine retinal microvascular SZ. Methods included 30 patients with SZ/schizoaffective disorder (8 early and 15 chronic) 22 healthy controls (HCs). All assessments were performed at Beth Israel Deaconess Medical Center Massachusetts Eye Ear. participants underwent OCT-A of right (oculus...
Box H/ACA RNAs are a group of small found in abundance eukaryotes (as well as archaea). Although their sequences differ, eukaryotic box all share the same unique hairpin-hinge-hairpin-tail structure. Almost them function guides that primarily direct pseudouridylation rRNAs and spliceosomal snRNAs at specific sites. RNA-guided has been extensively studied, detailed rules governing this reaction, especially those concerning guide RNA-substrate RNA base-pairing interactions determine...
To compare the efficacy of diabetic retinal neovascularisation (NV) detection using widefield swept-source optical coherence tomography angiography (WF SS-OCTA) vitreoretinal interface (VRI) Angio slab and SS-OCT VRI Structure slab.A prospective, observational study was performed at Massachusetts Eye Ear from January 2019 to June 2020. Patients with proliferative retinopathy (PDR), patients non-proliferative diabetes but without were included. All imaged WF SS-OCTA 12×12 mm scan protocol...
To determine if disorganisation of retinal inner layers (DRIL) is associated with reduced contrast sensitivity (CS) in patients vein occlusion (RVO) a history macular oedema (ME).Prospective, observational cohort study. Patients ME secondary to central (CRVO) or branch (BRVO) from October 2017 July 2019 at single institution were included. underwent complete ophthalmic examination, spectral domain optical coherence tomography (SD-OCT) and CS testing using the quick function (qCSF) method....
To characterize contrast sensitivity function (CSF) in cataractous and pseudophakic eyes compared to healthy control using a novel quantitative CSF test with active learning algorithms.This is prospective observational study at an academic medical center. was measured visually significant cataract, least 2+ nuclear sclerosis (NS) visual acuity (VA) ≥ 20/50, controls no more than 1+ NS complaints, the Manifold Contrast Vision Meter. Outcomes included Area under Log (AULCSF) CS thresholds 1,...
Optical coherence tomography angiography (OCT-A) has emerged as a novel tool for the non-invasive imaging and evaluation of retinal microvasculature. There is little existing literature that compares OCT-A microvasculature metrics across different devices in chorioretinal diseases. Herein, we examined these on three available platforms.All subjects were scanned each devices: Optovue Avanti Angiovue, Topcon DRI-OCT Triton Swept-Source OCT, Zeiss Cirrus 5000-HD-OCT Angioplex. Two investigators...
During the COVID-19 pandemic, there is growing concern that patients are forgoing necessary care. Emergency departments (ED) represent an important site of eye We analyzed patterns ED visits at eye-specific since declaration public health crisis.
Background and Objective: Our objective was to evaluate retinal microvascular changes visual outcomes following rhegmatogenous detachment (RRD) repair using wide-field swept-source optical coherence tomography angiography (WF SS-OCTA). Patients Methods: The study included 116 eyes of 111 patients with macula-off ( n = 68) or macula-on 48) RRD treated a single successful procedure, 79 fellow eyes, 183 control imaged WF SS-OCTA (3 ×3, 6 ×6, 12 ×12 mm images). Mixed-effects multiple linear...
BACKGROUND AND OBJECTIVE: To characterize contrast sensitivity function (CSF) in patients with retinal vein occlusion (RVO) compared to age-matched controls using novel computerized (CS) testing active learning algorithms. PATIENTS METHODS: CSF was prospectively measured RVO visual acuity (VA) greater than 20/200 and the Manifold Contrast Vision Meter implementing quantitative testing. Outcomes included area under Log (AULCSF), (CA), CS thresholds at 1, 1.5, 3, 12, 18 cycles per degree...