A5078339555- Retinal Diseases and Treatments
- Advanced Chemical Physics Studies
- Retinal Imaging and Analysis
- Spectroscopy and Laser Applications
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Atmospheric chemistry and aerosols
- Atmospheric Ozone and Climate
- Laser Design and Applications
- Photochemistry and Electron Transfer Studies
- Mass Spectrometry Techniques and Applications
- Retinal Development and Disorders
- Spectroscopy and Quantum Chemical Studies
- Intraocular Surgery and Lenses
- Metabolomics and Mass Spectrometry Studies
- Luminescence Properties of Advanced Materials
- Retinal and Macular Surgery
- Atomic and Subatomic Physics Research
- Molecular Junctions and Nanostructures
- Cold Atom Physics and Bose-Einstein Condensates
- Analytical chemistry methods development
- Atomic and Molecular Physics
- Catalytic Processes in Materials Science
- Ocular Diseases and Behçet’s Syndrome
- Radioactive element chemistry and processing
Massachusetts Eye and Ear Infirmary
2016-2025
Harvard University
2016-2025
The Retina Center
2019-2021
Harvard Vanguard Medical Associates
2016
University of Mississippi Medical Center
2016
Hanyang University
2016
Jackson Memorial Hospital
2016
Farabi Hospital
2016
Tehran University of Medical Sciences
2016
American Diabetes Association
2016
Retinal detachment (RD) is a sight-threatening complication common in many highly prevalent retinal disorders. RD rapidly leads to photoreceptor cell death beginning within 12 h following detachment. In patients with sustained RD, progressive visual decline due common, leading significant and permanent loss of vision. Microglia are the resident immune cells central nervous system, including retina, function homeostatic maintenance neuro-retinal microenvironment. It known that microglia...
To compare widefield swept-source optical coherence tomography angiography (WF SS-OCTA) with ultra-widefield colour fundus photography (UWF CFP) and fluorescein FA) for detecting diabetic retinopathy (DR) lesions.This prospective, observational study was conducted at Massachusetts Eye Ear from December 2018 to October 2019. Proliferative DR, non-proliferative DR patients no were included. All imaged a WF SS-OCTA using Montage 15×15 mm scan. UWF CFP FA taken by 200°, single capture retinal...
<h3>Objective:</h3> To compare the effectiveness of photodynamic therapy to close experimental choroidal neovascularization using an intravenous infusion liposomal benzoporphyrin derivative (verteporfin) with previous work a rapid injection, before initiating clinical trials. <h3>Methods:</h3> Choroidal was induced in cynomolgus monkey eyes argon laser. Liposomal delivered by pump for 10 or 32 minutes at dose 0.375 mg/kg. Irradiation performed 689- 692-nm laser light...
Time-resolved attenuation of the atomic emission transition C(33P°J→23PJ) at 166 nm has been used to study reactions C(23PJ). The decay this atom, following its generation by vacuum ultra-violet flash photolysis carbon suboxide, monitored directly in presence a number gases. rate data for 300 K have obtained: C(23PJ)+ NO →CN + O, k= 7.3±2.2 × 10–11 cm3 molecule–1 s–1, O2→CO 3,3±1.5 N2O →CO N2, 2.5±1.6 or CN NO, H2O H2k⩽3.6 10–13 CH2O, CO2→2CO, k≤ 10–14 CH4→C2H4, k < 2 10–15 N2+ M →CN2+ M,...
The recombination of oxygen atoms with O2 has been monitored directly using kinetic absorption spectroscopy in the vacuum ultra-violet. Oxygen were produced by photolysis O2(λ > 175 nm) and decay observed via resonance transitions (33S1→ 23PJ) region 130 nm a ultra-violet monochromator. experimental arrangement is described, results for Ar, Kr He as third bodies are reported. An upper limit reaction rate constant O+CO+M → CO2+M obtained body < 4.8 × 10–35 cm6 molecule–2 s–1.
To compare the choroidal thickness (CT) of diabetic eyes (different stages disease) with controls, using swept-source optical coherence tomography.
Purpose: To study the clinical features of endogenous endophthalmitis (EE) in sample patient populations from USA and South Korea over an 8-year period.Methods: We reviewed data 128 eyes 60 American 48 Korean patients diagnosed with EE compared their characteristics.Results: Fungemia liver abscess were most common extraocular infection sources among (26.7%) (33.3%), respectively. Klebsiella pneumoniae Candida species pathogens patients, Endophthalmitis caused by fungi had a better visual...
To differentiate the plasma metabolomic profile of patients with age related macular degeneration (AMD) from that controls, by Nuclear Magnetic Resonance (NMR) spectroscopy.Two cohorts (total 396 subjects) representative central Portugal and Boston, USA phenotypes were studied. For each cohort, subjects grouped according to AMD stage (early, intermediate late). Multivariate analysis NMR spectra was performed, followed signal integration univariate analysis.Small changes detected in levels...
To analyze imaging artifacts and segmentation errors with wide-field swept-source optical coherence tomography angiography (SS-OCTA) in diabetic retinopathy (DR).We conducted a prospective, observational study at Massachusetts Eye Ear from December 2018 to March 2019. Proliferative (PDR), nonproliferative (NPDR), patients no (DR), healthy control eyes were included. All imaged SS-OCTA the Montage Angio (15 × 9 mm) was used for analysis. Images independently evaluated by two graders using...
Age-related macular degeneration (AMD) is a leading cause of blindness in older adults. Investigating shared genetic components between metabolites and AMD can enhance our understanding its pathogenesis. We conduct metabolite genome-wide association studies (mGWASs) using multi-ethnic metabolomic data from up to 28,000 participants. With bidirectional Mendelian randomization analysis involving 16,144 advanced cases 17,832 controls, we identify 108 putatively causal relationships plasma AMD....
view Abstract Citations (81) References (28) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS Interstellar Carbon Chemistry: Reaction Rates of Neutral Atomic with Organic Molecules Clary, D. C. ; Haider, N. Husain, Kabir, M. Experimentally measured rate constants for the chemical reactions ground state carbon atoms several alkenes and alkynes are found to have surprisingly large values (approximately 10-10 - 10-9/cu cm molecule/s). The increase significantly...
To study the safety and efficacy of intravitreal injections anti-vascular endothelial growth factor antibody fragment (ranibizumab [formerly known as rhuFabV2], Lucentis; Genentech, South San Francisco, Calif) in combination with intravenous verteporfin (Visudyne; Novartis, East Hanover, NJ) photodynamic therapy (PDT) on experimental choroidal neovascularization monkey eye.Choroidal was induced by laser injury both eyes cynomolgus monkeys followed weekly fundus photography fluorescein...
Abstract Time‐resolved atomic absorption spectroscopy in the vacuum ultraviolet has been employed to monitor electronically excited oxygen atoms, O(2 1 D 2 ), following their genera‐tion by flash photolysis of ozone Hartley band region. We report first values for absolute second‐order rate constants describing removal atom on collision with molecules H , CH 4 NO, NO N O, and C 3 O . Where possible, these data are considered within context restrictions arising from spin orbital symmetry...
Abstract Electronically excited oxygen atoms O(2 1 D 2 ) have been generated by the pulsed irradiation of ozone in Hartley‐band continuum and monitored photoelectrically absorption time‐resolved attenuation atomic resonance radiation at λ = 115.2 nm [O(3 °) → )]. Collisional quenching atom has investigated for all noble gases, first absolute values second‐order deactivation rate constants are reported. The resulting data discussed terms a curve‐crossing mechanism based on existing...
Electronically excited nitrogen atoms, N(22DJ) and N(22PJ), generated by the pulsed irradiation of nitrous oxide in Schumann region, have been studied absorption time-resolved attenuation resonance radiation vacuum ultra-violet. The rate constants for collisional removal these species gases H2, N2, O2, NO N2O are reported. results compared with data ground-state atoms obtained from other methods, hence reactions 4S, 2D 2P states a given molecule discussed terms effects spin orbital symmetry....