A5046474056- Retinal Diseases and Treatments
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Birth, Development, and Health
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Glaucoma and retinal disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Myeloid Leukemia Research
- Protein Kinase Regulation and GTPase Signaling
- Endoplasmic Reticulum Stress and Disease
- Cancer-related Molecular Pathways
- Neuroscience and Neuropharmacology Research
- Radiology practices and education
- Ferroptosis and cancer prognosis
- Neuroblastoma Research and Treatments
- Cardiovascular Disease and Adiposity
- Cancer-related gene regulation
- Global Cancer Incidence and Screening
- Retinal Imaging and Analysis
- Mitochondrial Function and Pathology
- Retinal Development and Disorders
- DNA Repair Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Angiogenesis and VEGF in Cancer
University of Missouri–Kansas City
2022
City Vision University
2022
University of Newcastle Australia
2016-2021
Hunter Medical Research Institute
2021
Massachusetts Eye and Ear Infirmary
2018-2019
Harvard University
2017-2019
University of Oklahoma Health Sciences Center
2019
Boston Children's Hospital
2017
Retinal detachment (RD) is a sight-threatening complication common in many highly prevalent retinal disorders. RD rapidly leads to photoreceptor cell death beginning within 12 h following detachment. In patients with sustained RD, progressive visual decline due common, leading significant and permanent loss of vision. Microglia are the resident immune cells central nervous system, including retina, function homeostatic maintenance neuro-retinal microenvironment. It known that microglia...
Abstract Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a multi-functional that controls range of cellular functions, including proliferation, differentiation and apoptosis. The biological properties CaMKII are regulated by multi-site phosphorylation. However, the role phosphorylation plays in cancer cell metastasis has not been examined. We demonstrate herein expression at T286 increased breast when compared to normal tissue, CAMK2 mRNA associated with poor patient prognosis...
Peroxisome proliferator activated receptor-alpha (PPARα) is a ubiquitously expressed nuclear receptor. The role of endogenous PPARα in retinal neuronal homeostasis unknown. Retinal photoreceptors are the highest energy-consuming cells body, requiring abundant energy substrates. known regulator lipid metabolism, and we hypothesized that it may regulate use for oxidative phosphorylation energetically demanding neurons. We found essential maintenance survival neurons, with Pparα -/- mice...
Diabetic retinopathy (DR) is a common neurovascular complication of type 1 diabetes. Current therapeutics target neovascularization characteristic end-stage disease, but are associated with significant adverse effects. Targeting early events DR such as neurodegeneration may lead to safer and more effective approaches treatment. Two independent prospective clinical trials unexpectedly identified that the PPARα agonist fenofibrate had unprecedented therapeutic effects in DR, gave little...
Microglial activation and subsequent pathological neuroinflammation contribute to diabetic retinopathy (DR). However, the underlying mechanisms of microgliosis, means effectively suppress remain incompletely understood. Peroxisome proliferator-activated receptor alpha (PPARα) is a transcription factor that regulates lipid metabolism. The present study aimed determine if PPARα affects microgliosis in DR. In global Pparα mice, retinal microglia exhibited decreased structural complexity...
Brain and Acute Leukemia, Cytoplasmic (BAALC) is a protein that controls leukemia cell proliferation, differentiation, survival overexpressed in several cancer types. The gene located the chromosomal region 8q22.3, an area commonly amplified breast associated with poor prognosis. However, expression potential role of BAALC has not widely been examined. This study investigates human cancers aim determining if it plays pathogenesis disease. was examined by immunohistochemistry cancer, matched...
Introduction Acute myeloid leukaemia (AML) is the most common acute in adults and has one of poorest survival rates all cancers. Despite advancements treatments, 5 year rate for AML remains at 26%, less than 8% patients aged over 60. Approximately one-third exhibit primary refractory disease, however, mechanisms controlling this have not been fully elucidated. Overexpression brain leukaemia, cytoplasmic ( BAALC ) gene a negative prognostic factor associated with but precisely how...