A5069994659- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Retinal Diseases and Treatments
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- interferon and immune responses
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Eicosanoids and Hypertension Pharmacology
- Retinal Development and Disorders
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Kruppel-like factors research
- Bioinformatics and Genomic Networks
- Angiogenesis and VEGF in Cancer
- Thyroid Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
The Central Hospital of Xiao gan
2025
Wuhan University of Science and Technology
2025
Zhongnan Hospital of Wuhan University
2017-2024
Wuhan University
2017-2024
Zhujiang Hospital
2024
Southern Medical University
2024
Gansu Provincial Maternal and Child Health Hospital
2024
Southwest Jiaotong University
2024
Shanghai University
2024
Chengdu Medical College
2020-2023
Breast cancer is one of the most common malignancies in world. TWhile molecular mechanisms itsbreast pathogenesis are stillhas not to been investigatedcompletely revealed. The aim this study was identify potential crucial genes associated with progression breast cancer. Weighted gene co-expression network analysis (WGCNA) used construct free-scale networks for tohe exploreation theof associations between sets and clinical features, candidate biomarkers. expression profiles GSE1561 were...
Plasma proteins may often serve as indicators of disease and are a rich source for biomarker discovery. However, the intrinsic large dynamic range plasma makes analysis very challenging because number low abundance masked by few high proteins. The use prefractionation methods, such depletion higher before protein profiling, can assist in discovery detection less abundant that ultimately prove to be informative biomarkers. But there studies on comprehensive investigation both fractions...
The mouse model of laser-induced choroidal neovascularization (CNV) has been used in studies the exudative form age-related macular degeneration using both conventional slit lamp and a new image-guided laser system. A standardized protocol is needed for consistent results this model, which lacking. We optimized details CNV photocoagulation Four lesions with similar size were consistently applied per eye at approximately double disc diameter away from optic nerve, different power levels, mice...
Significance Pathologic vascular growth causes vision impairment in several eye diseases. Specifically targeting molecular signatures distinguishing pathologic neovascularization from normal vessels will allow targeted treatment options. This study demonstrates that miR-150 was specifically enriched retinal and down-regulated neovessels a mouse model of proliferative retinopathy. MiR-150 suppressed ocular mice with decreased expression angiogenic target genes inhibited endothelial cell...
Pathological neovessels growing into the normally avascular photoreceptors cause vision loss in many eye diseases, such as age-related macular degeneration and telangiectasia. Ocular neovascularization is strongly associated with inflammation, but source of inflammatory signals mechanisms by which these regulate disruption privilege are unknown. In this study, we found that c-Fos, a master regulator, was increased model pathological blood vessels invading photoreceptors: very low-density...
Breast cancer is one of the most common malignancies among females, and its prognosis affected by a complex network gene interactions. In this study, we constructed free-scale co-expression networks using weighted analysis (WGCNA). The expression profiles GSE25055 were downloaded from Gene Expression Omnibus (GEO) database to identify potential biomarkers associated with breast progression. GSE42568 was for validation. A total 9 modules established via average linkage hierarchical...
Retinal neuronal abnormalities occur before vascular changes in diabetic retinopathy. Accumulating experimental evidence suggests that neurons control pathology and other neovascular retinal diseases. Therefore, normalizing activity diabetes may prevent pathology. We investigated whether fibroblast growth factor 21 (FGF21) prevented dysfunction insulin-deficient mice. found neural retina, photoreceptor rather than inner function was most affected administration of the long-acting FGF21...
Abstract Background As one of the most common malignancy, lung adenocarcinoma (LUAD) is characterized by low 5-year survival rate. This research aimed to investigate effects ribonucleotide reductase regulatory subunit M2 (RRM2) on malignant biological behaviors and activation cGAS/STING pathway. We also explored synergistic sensitization mechanisms RRM2 radiotherapy. Methods Bioinformatic tools were used evaluate clinical significance in LUAD patients. The roles phenotype DNA damage cells...
The expression of long non-coding RNA (lncRNA) prostate cancer-associated ncRNA transcripts 1 (PCAT1) is increased in non-small cell lung cancer (NSCLC). It stimulates tumour growth and metastasis, but its role the radioimmune responses remain unknown. We aimed to explore impacts PCAT1 on tumorigenesis underlying molecular mechanisms NSCLC.Comprehensive bioinformatics analysis was performed identify immunosuppressive lncRNAs involved with invasion NSCLC. levels were analysed by situ...
Changes in IgG glycosylation, as a novel pathological feature, are observed various autoimmune diseases (AIDs). The glycosylation patterns of play critical role regulating the biological function and stability involved pathophysiology many AIDs. However, intracellular regulatory mechanisms underlying effects disturbances cytokines on poorly understood. Thus, we investigated elevated AIDs within B cells.First, established controlled primary culture system vitro to differentiate human CD19+...
Ubiquitin-conjugating enzyme E2T (UBE2T), a member of the ubiquitin-conjugating E2 family in ubiquitin-proteasome pathway, has been reported to be overexpressed certain tumor types and have an important role Fanconi anemia pathway. In present study, expression UBE2T its association with bladder cancer were investigated; best our knowledge, this not previously. Immunohistochemistry western blot analysis demonstrated that was significantly upregulated tissues cell lines compared adjacent...
Hepatic fibrosis is a necessary process in the development of liver diseases such as hepatic cirrhosis and its complications, which has become serious threat to human health. Currently, antifibrotic drug treatment ineffective, one reason should be lack targeting ability. In this report, polypeptide pPB-modified stable nucleic acid lipid nanoparticles (pPB-SNALPs) were prepared selectively deliver siRNAs against heat shock protein 47 for targeted therapy fibrosis. First, siRNA sequences with...
The neural cells and factors determining normal vascular growth are not well defined even though vision-threatening neovessel growth, a major cause of blindness in retinopathy prematurity (ROP) (and diabetic retinopathy), is driven by delayed growth. We here examined whether hyperglycemia low adiponectin (APN) levels retinal vascularization, primarily dysregulated photoreceptor metabolism. In premature infants, APN correlated with formation. Experimentally neonatal mouse model postnatal...
Highlights•FGF21 administration suppresses, and FGF21 deficiency worsens, ocular neovessel growth in mice•Suppression of retinal upon is mediated by adiponectin•FGF21 decreased TNF-α neovascular retinas•The inhibitory effects on eye neovascularization are independent VEGFASummaryPathological neovascularization, a leading cause blindness, seen retinopathy prematurity, diabetic retinopathy, age-related macular degeneration. Using mouse model hypoxia-driven we find that fibroblast factor 21...
As the most commonly diagnosed malignant tumor in female population, prognosis of breast cancer is affected by complex gene interaction networks. In this research weighted co-expression network analysis (WGCNA) would be utilized to build a identify potential biomarkers for prediction patients with cancer. We downloaded GSE25065 from Gene Expression Omnibus database as test set. GSE25055 and GSE42568 were validate findings research. Seven modules established utilizing average link...