A5024251521- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Metabolomics and Mass Spectrometry Studies
- Ocular Diseases and Behçet’s Syndrome
- Intraocular Surgery and Lenses
- Antioxidant Activity and Oxidative Stress
- Retinal and Macular Surgery
- Ocular Oncology and Treatments
- Ophthalmology and Visual Impairment Studies
- Ocular Infections and Treatments
- Retinal Development and Disorders
- Facial Trauma and Fracture Management
- Traumatic Ocular and Foreign Body Injuries
- Ophthalmology and Visual Health Research
- Corneal surgery and disorders
- Cerebral Venous Sinus Thrombosis
- Mosquito-borne diseases and control
- Medical Education and Admissions
- Cardiovascular Health and Risk Factors
- Traditional Chinese Medicine Studies
- melanin and skin pigmentation
- Ergonomics and Musculoskeletal Disorders
- Optical Imaging and Spectroscopy Techniques
Massachusetts Eye and Ear Infirmary
2016-2025
Harvard University
2016-2025
The Retina Center
2019-2022
Association for Innovation and Biomedical Research on Light and Image
2015-2021
University of Coimbra
2014-2020
Hospitais da Universidade de Coimbra
2013-2020
To compare widefield swept-source optical coherence tomography angiography (WF SS-OCTA) with ultra-widefield colour fundus photography (UWF CFP) and fluorescein FA) for detecting diabetic retinopathy (DR) lesions.This prospective, observational study was conducted at Massachusetts Eye Ear from December 2018 to October 2019. Proliferative DR, non-proliferative DR patients no were included. All imaged a WF SS-OCTA using Montage 15×15 mm scan. UWF CFP FA taken by 200°, single capture retinal...
To compare the choroidal thickness (CT) of diabetic eyes (different stages disease) with controls, using swept-source optical coherence tomography.
To differentiate the plasma metabolomic profile of patients with age related macular degeneration (AMD) from that controls, by Nuclear Magnetic Resonance (NMR) spectroscopy.Two cohorts (total 396 subjects) representative central Portugal and Boston, USA phenotypes were studied. For each cohort, subjects grouped according to AMD stage (early, intermediate late). Multivariate analysis NMR spectra was performed, followed signal integration univariate analysis.Small changes detected in levels...
Age-related macular degeneration (AMD) is a leading cause of blindness in older adults. Investigating shared genetic components between metabolites and AMD can enhance our understanding its pathogenesis. We conduct metabolite genome-wide association studies (mGWASs) using multi-ethnic metabolomic data from up to 28,000 participants. With bidirectional Mendelian randomization analysis involving 16,144 advanced cases 17,832 controls, we identify 108 putatively causal relationships plasma AMD....
In Brief Purpose: To analyze the effect of anti–vascular endothelial growth factor agents (anti-VEGF) in submacular choroidal thickness (CT) diabetic retinopathy (DR) patients. Methods: Cross-sectional study, which included 25 DR patients (50 eyes) divided 2 groups, according to stage and previous treatments: nonproliferative diffuse macular edema both eyes, submitted laser eyes anti-VEGF injection only 1 eye (nonproliferative + group, n = 11); proliferative treated with panretinal...
The pathogenesis of age-related macular degeneration (AMD), a leading cause blindness worldwide, remains only partially understood. This has led to the current lack accessible and reliable biofluid biomarkers for diagnosis prognosis, absence treatments dry AMD. study aimed assess plasma metabolomic profiles AMD its severity stages with ultimate goal contributing addressing these needs. We recruited two cohorts: Boston, United States (n = 196) Coimbra, Portugal 295). Fasting blood samples...
Introduction Contrast sensitivity function (CSF) may better estimate a patient’s visual compared with acuity (VA). Our study evaluates the quick CSF (qCSF) method to measure in eyes macular disease and good letter acuity. Methods Patients maculopathies (retinal vein occlusion, macula-off retinal detachment, dry age-related degeneration wet degeneration) (VA ≥20/30) were included. The qCSF uses an intelligent algorithm across multiple spatial frequencies. All maculopathy combined individual...
To study the wider field swept-source optical coherence tomography angiography (WF SS-OCTA) metrics, especially non-perfusion area (NPA), in diagnosing and staging of DR.Cross-sectional observational (November 2018-September 2020).473 eyes 286 patients (69 49 control 404 237 diabetic patients).We imaged using 6mm×6mm 12mm×12mm angiograms on WF SS-OCTA. Images were analyzed ARI Network FIJI ImageJ. Mixed effects multiple regression models receiver operator characteristic analysis was used for...
Abstract Background Widespread use of retinal optical coherence tomography angiography (OCT-A) imaging in population-based studies requires methodological and analytical consensus to ensure reproducible accurate results. Objective Development a framework for assessment OCT-A image quality working with OCT-A-derived variables population studies. Methods Criteria were developed fovea-centered, 3x3-mm images acquired three commercially available devices. Inter- intragrader agreements overall...
Background/aims To investigate the association between plasma metabolomic profiles and treatment response after intravitreal anti-vascular endothelial growth factor (VEGF) injections in treatment-naïve neovascular age-related macular degeneration (nAMD). Methods This is part of a prospective longitudinal study that included patients with nAMD who have undergone three loading anti-VEGF injections. All underwent ophthalmological examinations including spectral domain optical coherence...
Background: Best-corrected visual acuity (BCVA) is the current gold standard of retinal function measurement but not affected in early and intermediate forms age-related macular degeneration (AMD). Increasing evidence suggests that microperimetry a sensitive measure function. This study sought to analyze associations between plasma urine metabolites AMD. Methods: We included data on 363 eyes (95 controls, 268 AMD). Microperimetry was performed patients with or without AMD using Macular...
To analyze the efficacy and safety of topography-guided photorefractive keratectomy (TG-PRK) to treat irregular astigmatism after corneal transplantation.This was a retrospective observational case series. Eyes with penetrating keratoplasty treated TG-PRK (Allegretto Wave Eye-Q) customized ablation treatment protocol were included. All treatments had been planned correct topographic irregularities, as well reduce refractive error neutralizing induced change. Clinical records, plan,...
BACKGROUND AND OBJECTIVE: To compare patterns of choroidal hypoperfusion in white dot syndromes (WDS) using optical coherence tomography angiography (OCTA). PATIENTS METHODS: Consecutive patients with WDS were imaged either the Zeiss AngioPlex OCT Angiography (Carl AG, Oberkochen, Germany) or AngioVue (Optovue, Fremont, CA) from February to November 2016. Four acute posterior multifocal placoid pigment epitheliopathy (APMPPE), birdshot chorioretinopathy (BCR), presumed ocular histoplasmosis...
Abstract Purpose To characterize the lifestyle and nutritional risk profile associated with Mediterranean diet in a Portuguese population without age‐related macular degeneration ( AMD ). Methods Nested case–control study n = 883) within Coimbra Eye Study, including 434 subjects 449 age‐ sex‐matched . All enrolled underwent full assessment, lifestyle‐related factors thorough food frequency questionnaire. This allowed us to build an adherence score (mediSCORE, range 0–9) constructed from...