Luisa Sánchez Brea

ORCID: 0000-0002-4061-4846
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About
Contact & Profiles
Research Areas
  • Retinal Imaging and Analysis
  • Glaucoma and retinal disorders
  • Retinal Diseases and Treatments
  • Optical Coherence Tomography Applications
  • Ocular Surface and Contact Lens
  • Retinal and Optic Conditions
  • Optimization and Variational Analysis
  • Retinal and Macular Surgery
  • Corneal surgery and disorders
  • E-Learning and Knowledge Management
  • Advanced Banach Space Theory
  • Ovarian cancer diagnosis and treatment
  • Photoacoustic and Ultrasonic Imaging
  • Ophthalmology and Visual Impairment Studies
  • University-Industry-Government Innovation Models
  • Approximation Theory and Sequence Spaces
  • Infant Development and Preterm Care
  • Peripheral Artery Disease Management
  • Ocular Infections and Treatments
  • Higher Education Teaching and Evaluation
  • Biomedical Research and Pathophysiology
  • Inflammatory Biomarkers in Disease Prognosis
  • Fixed Point Theorems Analysis
  • Visual perception and processing mechanisms
  • Image Processing Techniques and Applications

Erasmus MC
2019-2024

Erasmus University Rotterdam
2019-2024

Rotterdam Eye Hospital
2024

Clinica Universidad de Navarra
2022-2024

Central University of Valle del Cauca
2023

Centro Médico Nacional La Raza
2022

Universidade da Coruña
2013-2017

European Commission
2013

University of the Andes
2000-2009

Universidad de Extremadura
2004

Abstract Background Widespread use of retinal optical coherence tomography angiography (OCT-A) imaging in population-based studies requires methodological and analytical consensus to ensure reproducible accurate results. Objective Development a framework for assessment OCT-A image quality working with OCT-A-derived variables population studies. Methods Criteria were developed fovea-centered, 3x3-mm images acquired three commercially available devices. Inter- intragrader agreements overall...

10.1101/2025.01.22.25320610 preprint EN cc-by medRxiv (Cold Spring Harbor Laboratory) 2025-01-26

We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) OCT angiography (OCTA) modalities provides fields of view. For high resolution, lateral resolution in particular, cellular correction aberrations by adaptive optics (AO) is employed. entire has design the head mounted on motorized translation stages that enable 3D...

10.1038/s41598-022-13631-1 article EN cc-by Scientific Reports 2022-06-10

Abstract This study tested if a high-resolution, multi-modal, multi-scale retinal imaging instrument can provide novel information about structural abnormalities in vivo. The examined 11 patients with very mild to moderate non-proliferative diabetic retinopathy (NPDR) and 10 healthy subjects using fundus photography, optical coherence tomography (OCT), OCT angiography (OCTA), adaptive optics scanning laser ophthalmoscopy (AO-SLO), OCTA (AO-OCT(A)). Of 21 eyes of patients, had NPDR, 8 2 1 no...

10.1038/s41598-024-63749-7 article EN cc-by Scientific Reports 2024-06-11

Motion artefacts from involuntary changes in eye fixation remain a major imaging issue optical coherence tomography (OCT). This paper reviews the state-of-the-art of retrospective procedures to correct retinal motion and axial OCT imaging. Following an overview induced correction strategies, chronological survey approaches since introduction until current days is presented. Pre-processing, registration, validation techniques are described. The review finishes by discussing limitations...

10.3390/app9132700 article EN cc-by Applied Sciences 2019-07-02

To develop and assess an automatic procedure for classifying staging glaucomatous vascular damage based on optical coherence tomography angiography (OCTA) imaging.OCTA scans (Zeiss Cirrus 5000 HD-OCT) from a random eye of 39 healthy subjects 82 glaucoma patients were used to new classification algorithm multilayer multisector information. The averaged circumpapillary retinal nerve fiber layer (RNFL) thickness was also collected. Three models, support vector machine (SVM), forest (RF),...

10.1167/tvst.9.2.58 article EN cc-by-nc-nd Translational Vision Science & Technology 2020-11-05

The Continuous bright light conditions to which premature infants are subjected while hospitalized in Neonatal Intensive Care Units (NICU) can have deleterious effects terms of growth and development. This study evaluates the benefits a light/darkness cycle (LDC) weight early hospital discharge from NICU. Subjects were recruited three participating institutions Mexico. Eligible patients (n = 294) who low-risk high-risk neonatal units classified as stable. subjects randomized experimental...

10.1038/s41598-022-22533-1 article EN cc-by Scientific Reports 2022-10-20

Conjunctival hyperemia or conjunctival redness is a symptom that can be associated with broad group of ocular diseases. Its levels severity are represented by standard photographic charts visually compared the patient’s eye. This way, diagnosis becomes nonrepeatable task depends on experience grader. To solve this problem, we have proposed computer-aided methodology comprises three main stages: segmentation conjunctiva, extraction features in region based colour and presence blood vessels,...

10.1155/2016/3695014 article EN cc-by Computational and Mathematical Methods in Medicine 2016-01-01

Abstract Background: Rucaparib is a poly(ADP-ribose) polymerase inhibitor approved in Europe as maintenance therapy for recurrent platinum-sensitive (Pt-S) ovarian cancer (OC). The Access Programme (RAP) was designed to provide early access rucaparib the above-mentioned indication, well patients with BRCA -mutated Pt-S or platinum-resistant (Pt-R) OC and no therapeutic alternatives. Methods: In this observational, retrospective study we analysed efficacy safety of within RAP Spain. Hospitals...

10.1186/s12885-022-10191-5 article EN cc-by BMC Cancer 2022-11-08

This paper presents a novel image analysis strategy that increases the potential of macular Optical Coherence Tomography (OCT) by using speckle features as biomarkers in different stages glaucoma. A large pool (480) were computed for subset OCT volumes Leuven eye study cohort. The dataset contained 258 subjects divided into four groups based on their glaucoma severity: Healthy (56), Mild (94), Moderate (48), and Severe (60). categorized statistical properties, distributions, contrast,...

10.1016/j.compmedimag.2023.102256 article EN cc-by Computerized Medical Imaging and Graphics 2023-06-08

Abstract Background Acute Retinal Pigment Epitheliitis (ARPE, Krill’s disease) is a rare inflammatory retinal disorder commonly affecting young adults. It often presents unilaterally with central vision disruption, and typically resolves restoration within 6 to 12 weeks. The pathogenesis of ARPE remains subject ongoing debate. Adaptive Optics Flood Illumination Ophthalmoscopy (AO-FIO) imaging has emerged as valuable tool capable detecting early cone photoreceptor changes recovery. This case...

10.1186/s12886-024-03768-0 article EN cc-by BMC Ophthalmology 2024-11-24

Hyperemia is the occurrence of redness in a certain tissue. When it takes place on bulbar conjunctiva, can be an early symptom different pathologies, hence, importance its quick evaluation. Experts grade hyperemia as value continuous scale, according to severity level. As subjective and time consuming task, automatisation priority for optometrists. To this end, several image features are computed from video frame that shows patient’s eye. Then, these transformed grading scale by means...

10.5220/0005756004230429 article EN Proceedings of the 14th International Conference on Agents and Artificial Intelligence 2016-01-01
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