A5031263310- Cancer Treatment and Pharmacology
- PARP inhibition in cancer therapy
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Ovarian cancer diagnosis and treatment
- Venous Thromboembolism Diagnosis and Management
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Chemotherapy-induced cardiotoxicity and mitigation
- Prostate Cancer Treatment and Research
- Advanced Breast Cancer Therapies
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Aging, Health, and Disability
- Advancements in Semiconductor Devices and Circuit Design
- Gastric Cancer Management and Outcomes
- Medical research and treatments
- Radiopharmaceutical Chemistry and Applications
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
Hospital Lluis Alcanyis
2021-2024
Mexican Social Security Institute
2024
Hospital Universitari i Politècnic La Fe
2013-2023
Pierre Fabre (Germany)
2023
Novartis (Switzerland)
2023
Seagen (Canada)
2023
Pfizer (Netherlands)
2023
Central University of Ecuador
2023
Roche (Switzerland)
2023
Daiichi Sankyo (Germany)
2023
The COVID-19 pandemic has generated an avalanche of information, which, if not properly addressed, generates uncertainty and limits healthy decision-making. On the other hand, exacerbated mental health problems among young people adolescents, causing a worsening their wellbeing. Previous studies have found that digital literacy positive impact on people's attitudes toward disease. This study aimed to analyze association between with subjective wellbeing in university students.A...
La nanotecnología ha transformado la biología moderna, abriendo nuevas posibilidades en el diagnóstico, tratamiento y prevención de enfermedades. Este artículo profundiza cómo nanomedicina impulsado avances clave, como administración dirigida fármacos, que reduce los efectos secundarios mejora eficacia terapias contra cáncer enfermedades cardiovasculares. Se exploran sistemas nanoliposomas, las nanopartículas dendrímeros, permiten liberar medicamentos manera controlada protegerlos su...
O presente estudo visa analisar como a gestão adequada de conflitos pode contribuir para o enfrentamento do luto simbólico nos fins relacionamentos conjugais presentes no Direito Família Brasil. A partir método dialético, estudam-se as relações familiares, considerando suas características e, em especial, possibilidade continuidade vínculos após separação conjugal. Em seguida, analisa-se conceito amor líquido e simbólico, avaliando crescente recorrência rupturas modernos, que influencia...
Triple-negative breast cancer (TNBC) is characterised by high pathological complete response to neoadjuvant chemotherapy (NAC). However, refractory and poor NAC responders still face very outcome, emphasising the urgent need for tools that facilitate identification of these patients, so surgery or alternatives are considered early in treatment protocol.We combined metabolomics, exosome circulating miRNAs flow cytometry experimental approaches TNBC patients at diagnosis with...
Thrombosis may be included in the profile of side effects associated with CDK4/6 inhibitors. Its significance might greater than reported randomized clinical trials. To investigate this, a retrospective, multicenter study was conducted. The primary objective to calculate incidence thrombosis Secondary objectives examining impact on survival and identifying predictor variables for development venous thromboembolism (VTE) or arterial (AT). A total 986 patients were recruited. VTE/AT inhibitor...
Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco alcohol consumption are most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis tumour suppressing activity. To investigate importance of this pathway HNSCC susceptibility, factor matched case-control association study was performed four candidate polymorphisms autophagy genes (ATG2B, ATG5, ATG10, ATG16L1). We found an between...
Despite classical environmental risk factors like tobacco, alcohol or viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility produced by single nucleotide polymorphisms (SNPs) is an important task. A total 296 human papillomavirus negative cancer (HNC) patients (126 laryngeal, 100 pharyngeal 70 oral cavity) were included in study, involving 29 candidate SNPs genes within carcinogenic pathways (oncogenesis tumour suppression,...
Anthracycline-induced cardiotoxicity is the most severe collateral effect of chemotherapy originated by an excess oxidative stress in cardiomyocytes that leads to cardiac dysfunction. We assessed clinical data from patients with breast cancer receiving anthracyclines and searched for discriminating microRNAs between developed (cases) those did not (controls), using RNA sequencing regression analysis. Serum levels 25 were differentially expressed cases versus controls within first year after...
The establishment of precision medicine in cancer patients requires the study several biomarkers. Single-gene testing approaches are limited by sample availability and turnaround time. Next generation sequencing (NGS) provides an alternative for detecting genetic alterations genes with low requirements. Here we show implementation to routine diagnostics a NGS assay under International Organization Standardization (UNE-EN ISO 15189:2013) accreditation. For this purpose, 106 non-small cell...
Abstract Background: Rucaparib is a poly(ADP-ribose) polymerase inhibitor approved in Europe as maintenance therapy for recurrent platinum-sensitive (Pt-S) ovarian cancer (OC). The Access Programme (RAP) was designed to provide early access rucaparib the above-mentioned indication, well patients with BRCA -mutated Pt-S or platinum-resistant (Pt-R) OC and no therapeutic alternatives. Methods: In this observational, retrospective study we analysed efficacy safety of within RAP Spain. Hospitals...
Abstract Background The purpose of this study is to present our first results sentinel node analysis (SLN) by one step nucleic acid amplification (OSNA) in routine clinical practice centre and compare them with the classic histopathological a historical cohort from same institution. Methods 407 patients (total population) early breast cancer no nodal involvement underwent SLN biopsy was analysed OSNA 164 biopsies. were compared conventional histopathology 244 who had undergone previously....
The poly(ADP-ribose) polymerase inhibitor (PARPi) rucaparib is approved as maintenance therapy for patients with platinum-sensitive recurrent high-grade ovarian cancer (HGOC). efficacy and safety of after PARPi are largely unknown; therefore, we analyzed outcomes in the subgroup PARPi-pretreated from Spanish hospitals participating Rucaparib Access Program. This post hoc analysis explored baseline characteristics, treatment exposure, safety, effectiveness, subsequent among women receiving...
Background: Primary cardiac tumors are extremely rare; most myxomas with a benign prognosis. However, primary sarcomas highly aggressive and treatment options limited. Radical surgery is often not feasible conventional therapies provide only modest results. Due to the rare nature of tumors, there no proper randomized studies guide treatment. Their complexity requires alternative approaches in order improve efficacy. Methods: We isolated DNA from 5 sarcomas; quality 3 them was sufficient...
Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) are the standard treatment of advanced, EGFR-mutant non-small-cell lung cancer (NSCLC). Usually, radiographic assessment response to chemotherapy is performed after patient completes second course treatment. The optimal timing evaluation for patients receiving EGFR-TKIs is, however, not well-defined. purpose this study evaluate association an early radiological (ERR) TKIs by computed tomography (CT) with...
The current situation of palliative care. Review a non-standardized situationEn los últimos 50 años la medicina ha evolucionado más que en dos siglos anteriores.Sin embargo, existen actualidad multitud de patologías contemporánea no sido capaz solventar.Hasta hace tan solo unas décadas, niños diagnosticados cáncer fallecían poco tiempo.Así pues, esto ido modificándose y mitad llegan ser supervivientes largo plazo.Los cuidados paliativos como especialidad se han desarrollado forma marcada...
Antecedentes: El octreótido ha demostrado en estudios experimentales reducir el daño histopatológico y shock hemodinámico pancreatitis inducida por ácido ursodesoxicólico. investigador Frank Axel Wenger mostró que la administración temprana de disminuye severidad los cambios histopatológicos aguda. La base farmacológica del uso se encuentra su capacidad para secreción enzimas pancreáticas, ya tripsina activada desencadena una serie digestivas dañan tejido pancreático. Objetivo: Describir...