A5083998794- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Optical Coherence Tomography Applications
- Retinal and Macular Surgery
- Optical Imaging and Spectroscopy Techniques
- Ocular Diseases and Behçet’s Syndrome
- Retinopathy of Prematurity Studies
- Intraocular Surgery and Lenses
- Systemic Lupus Erythematosus Research
- Ocular Infections and Treatments
- Drug-Induced Ocular Toxicity
- Cerebrovascular and Carotid Artery Diseases
- Renal and Vascular Pathologies
- Neuroscience and Neuropharmacology Research
- Amino Acid Enzymes and Metabolism
- Spectroscopy Techniques in Biomedical and Chemical Research
- Alzheimer's disease research and treatments
- Photoacoustic and Ultrasonic Imaging
- Vascular Malformations Diagnosis and Treatment
- Non-Invasive Vital Sign Monitoring
- Ocular Oncology and Treatments
- Cardiovascular Health and Disease Prevention
Johns Hopkins Medicine
2002-2025
Johns Hopkins University
2001-2025
Johns Hopkins Hospital
2021-2025
Alzheimer’s Disease Neuroimaging Initiative
2023
Union Bank of Switzerland
2023
University of Southern California
2012-2022
Southern California Eye Institute
2015-2021
Qazvin University of Medical Sciences
2021
Biomedical Research Institute of Southern California
2019
LAC+USC Medical Center
2018
Purpose: To quantify changes in retinal microvasculature diabetic retinopathy (DR) by using spectral-domain optical coherence tomography angiography (SD-OCTA). Methods: Retrospective, cross-sectional, observational study of healthy and adult subjects with without DR. Retinal microvascular were assessed SD-OCTA images an intensity-based microangiography algorithm. A semiautomated program was used to calculate indices density morphology nonsegmented segmented images. Microvascular quantified...
Implantation of a human embryonic stem cell–derived retinal pigment epithelial monolayer is feasible in subjects with advanced, dry age-related macular degeneration.
BACKGROUND AND OBJECTIVE: To noninvasively evaluate the retinal microvasculature in healthy human subjects with optical coherence tomography angiography (OCTA). PATIENTS METHODS: Cross-sectional, observational study of five subjects. OCTA was performed on 3 × mm 2 sections centered fovea, nasal macula, and temporal macula. Retinal vasculature assessed within three horizontal slabs consisting inner, middle, outer retina. The each slab reconstructed using phase-based intensity contrast-based...
BACKGROUND AND OBJECTIVE: Optical coherence tomography angiography (OCTA) is a novel, non-invasive OCT technique capable of imaging the retinal vasculature. This study aims to evaluate microvasculature in diabetic human subjects with OCTA and assess potential clinical applications. PATIENTS METHODS: Cross-sectional 33 retinopathy. was performed on 3 mm × sections using swept-source prototype phase- intensity-based contrasting algorithm. angiograms were studied corresponding examination...
Serine racemase (SR), localized to astrocytic glia that ensheathe synapses, converts l -serine d -serine, an endogenous ligand of the NMDA receptor. We report activation SR by glutamate neurotransmission involving α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors via receptor interacting protein (GRIP) and physiologic regulation cerebellar granule cell migration SR. GRIP physiologically binds SR, augmenting activity release. infection neonatal mouse cerebellum in vivo enhances...
To noninvasively evaluate the retinal microvasculature in human subjects with venous occlusions using optical coherence tomography angiography and assess potential clinical applications.This was a prospective, observational study of adult imaging findings demonstrating occlusion. Subjects underwent complete ophthalmic examination fluorescein as appropriate for their standard care. Optical performed on prototype spectral domain-OCTA system 3 mm × 6 regions centered fovea parafoveal areas....
Purpose To quantitatively evaluate the retinal microvasculature in human subjects with venous occlusions (RVO) using optical coherence tomography angiography (OCTA). Design Retrospective, cross-sectional, observational case series. Participants Sixty (84 eyes) were included (20 BRVO, 14 CRVO, 24 unaffected fellow eyes, and 26 controls). Methods OCTA was performed on a prototype, spectral domain-OCTA system 3x3mm central macular region. Custom software used to quantify morphology density of...
Purpose: To report 1-year follow-up of a phase 1/2a clinical trial testing composite subretinal implant having polarized human embryonic stem cell (hESC)-derived retinal pigment epithelium (RPE) cells on an ultrathin parylene substrate in subjects with advanced non-neovascular age-related macular degeneration (NNAMD) Methods: The included 16 two cohorts. main endpoint was safety assessed at 365 days using ophthalmic and systemic exams. Pseudophakic geographic atrophy (GA) severe vision loss...
Abstract The MarkVCID consortium was formed under cooperative agreements with the National Institute of Neurologic Diseases and Stroke (NINDS) on Aging (NIA) in 2016 goals developing validating biomarkers for cerebral small vessel diseases associated vascular contributions to cognitive impairment dementia (VCID). Rigorously validated have consistently been identified as crucial multicenter studies identify effective strategies prevent treat VCID, specifically detect increased VCID risk,...
Abstract Visible light optical coherence tomography (VIS-OCT) is an emerging ophthalmic imaging method featuring ultrahigh depth resolution, retinal microvascular oximetry, and distinct scattering contrast in the visible spectral range. The clinical utility of VIS-OCT hampered by fundamental trade-off between range axial which are determined resolution bandwidth, respectively. To address this trade-off, here we developed a dual-channel system with three major advancements including first...
Endogenous endophthalmitis (EE) is a rare but devastating infection that occurs secondary to seeding of the intraocular cavity from an extraocular focus. Recent reports suggest increasing prevalence and incidence Klebsiella pneumoniae as causative organism in Asian countries. Analysis largest cohorts published date suggests K. endogenous (KPEE) 10 15 times more prevalent than other causes EE. The KPEE among patients with systemic appears be >100-fold common exact reason for these...
3D optical coherence tomography angiography (OCT-A) is a novel and non-invasive imaging modality for analyzing retinal diseases. The studies of microvasculature in 2D en face projection images have been widely implemented, but comprehensive analysis OCT-A with rich depth-resolved microvascular information rarely considered. In this paper, we propose robust, effective, automatic shape modeling framework to provide high-quality vessel representation preserve valuable geometric topological...
Cell-based therapies face challenges, including poor cell survival, immune rejection, and integration into pathologic tissue. We conducted an open-label phase 1/2a clinical trial to assess the safety preliminary efficacy of a subretinal implant consisting polarized monolayer allogeneic human embryonic stem cell-derived retinal pigmented epithelium (RPE) cells in subjects with geographic atrophy (GA) secondary dry age-related macular degeneration. Postmortem histology from one subject very...
To develop a consensus nomenclature for reporting OCT angiography (OCTA) findings in retinal vascular disease (e.g., diabetic retinopathy, vein occlusion) by international experts. Delphi-based survey. Twenty-five and OCTA imaging A Delphi method of development was used, comprising 2 rounds online questionnaires, followed face-to-face meeting conducted virtually. experts were selected to constitute the Nomenclature Study Group disease. The 4 main areas were: definition parameters "wide-field...