A5057183556- Retinal Development and Disorders
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Impairment Studies
- Neurogenesis and neuroplasticity mechanisms
- Metal complexes synthesis and properties
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
University of Southern California
2018-2022
Southern California Eye Institute
2018-2022
McGill University
2001-2007
Implantation of a human embryonic stem cell–derived retinal pigment epithelial monolayer is feasible in subjects with advanced, dry age-related macular degeneration.
A discrete cyclic nanostructure was obtained through the self-assembly of oligonucleotide-branched metal complexes. The picture shows metal–DNA nanostructure, which contains two DNA double-helical arms and relatively rigid redox- photoactive [Ru(bpy)3]2+ vertices. Supporting information for this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z460255_s.pdf or from author. Please note: publisher not responsible content functionality any supporting supplied by...
Abstract Patients diagnosed with Retinitis Pigmentosa (RP) show, in the advanced stage of disease, severely restricted peripheral vision causing poor mobility and decline quality life. This loss causes difficulty identifying obstacles their relative distances. Thus, RP patients use aids such as canes to navigate, especially dark environments. A number high-tech visual using virtual reality (VR) sensory substitution have been developed support or supplant traditional aids. These not achieved...
Die verzweigte DNA-Struktur 1, in der sich ein Übergangsmetallzentrum am Verzweigungspunkt befindet und zwei parallele DNA-Stränge verknüpft, ließ einer konvergenten Festphasensynthese herstellen. 1 hybridisiert effizient mit komplementärer DNA zu Übergangsmetall-verknüpften DNA-Duplexen. Hiermit sollte es möglich werden, die Geometrien von Übergangsmetallkomplexen nutzen, um Assoziation neuartigen Motiven anzustoßen.
Current studies of lariat RNA structure and function are hindered by the lack access to synthetic lariats. A novel approach synthesis both DNA lariats is presented here. Noteworthy features methodology regiospecific formation 2'-5'-phosphodiester linkage, unusual parallel stranded DNA/RNA hybrid (or RNA/RNA duplex) that forms between an template a folded 22-nt RNA) substrate, efficiency chemical ligation step at adenosine branchpoint (50−80%). The were purified polyacrylamide gel...
Retinal degeneration, such as age-related macular degeneration (AMD), is a leading cause of blindness worldwide. A myriad approaches have been undertaken to develop regenerative medicine-based therapies for AMD, including stem cell-based therapies. Rodents animal models retinal are foundation translational research, due the broad spectrum strains that diseases at different stages. However, mimicking human therapeutic delivery subretinal implants in rodents challenging, anatomical differences...
Retinal degeneration, such as age-related macular degeneration (AMD), is a leading cause of blindness worldwide. A myriad approaches have been undertaken to develop regenerative medicine-based therapies for AMD, including stem cell-based therapies. Rodents animal models retinal are foundation translational research, due the broad spectrum strains that diseases at different stages. However, mimicking human therapeutic delivery subretinal implants in rodents challenging, anatomical differences...