A5039795449- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Retinal Imaging and Analysis
- Plant Virus Research Studies
- Legume Nitrogen Fixing Symbiosis
- Healthcare Policy and Management
- Healthcare Technology and Patient Monitoring
- Advanced Biosensing Techniques and Applications
- Ocular Diseases and Behçet’s Syndrome
- Phytase and its Applications
- Entomopathogenic Microorganisms in Pest Control
- Lymphoma Diagnosis and Treatment
- Healthcare Operations and Scheduling Optimization
- Plant Stress Responses and Tolerance
- Ion channel regulation and function
- Library Science and Information Systems
- Health Policy Implementation Science
- Pharmaceutical industry and healthcare
- Optical Coherence Tomography Applications
- Single-cell and spatial transcriptomics
- Electronic Health Records Systems
- Patient-Provider Communication in Healthcare
- Non-Invasive Vital Sign Monitoring
National Patient Safety Foundation
2024
Brigham and Women's Hospital
2011-2024
RAND Corporation
2018-2024
Salk Institute for Biological Studies
2016-2021
Loma Linda University
2021
Southern California Eye Institute
2016-2018
University of Southern California
2015-2018
Memorial Hospital of Rhode Island
2011-2015
Purpose: To quantify changes in retinal microvasculature diabetic retinopathy (DR) by using spectral-domain optical coherence tomography angiography (SD-OCTA). Methods: Retrospective, cross-sectional, observational study of healthy and adult subjects with without DR. Retinal microvascular were assessed SD-OCTA images an intensity-based microangiography algorithm. A semiautomated program was used to calculate indices density morphology nonsegmented segmented images. Microvascular quantified...
Abscisic acid (ABA) is a plant hormone that mediates abiotic stress tolerance and regulates growth development. ABA binds to members of the PYL/RCAR receptor family initiate signal transduction inhibiting type 2C protein phosphatases. Although crosstalk between Jasmonic Acid (JA) has been shown, molecular entities mediate this interaction have yet be fully elucidated. We report link JA signaling through direct PYL6 (RCAR9) with basic helix-loop-helix transcription factor MYC2. MYC2 interact...
Purpose To quantitatively evaluate the retinal microvasculature in human subjects with venous occlusions (RVO) using optical coherence tomography angiography (OCTA). Design Retrospective, cross-sectional, observational case series. Participants Sixty (84 eyes) were included (20 BRVO, 14 CRVO, 24 unaffected fellow eyes, and 26 controls). Methods OCTA was performed on a prototype, spectral domain-OCTA system 3x3mm central macular region. Custom software used to quantify morphology density of...
Protein microarrays enable investigation of diverse biochemical properties for thousands proteins in a single experiment, an unparalleled capacity. Using high-density system called HaloTag nucleic acid programmable protein array (HaloTag-NAPPA), we created arrays comprising 12,000 Arabidopsis ORFs. We used these to query protein-protein interactions set 38 transcription factors and transcriptional regulators (TFs) that function plant hormone regulatory pathways. The resulting factor...
Cathepsin S (CTSS) activity is elevated in Sjögren's Syndrome (SS) patient tears. Here we tested whether protease inhibition and cystatin C (Cys C) levels are reduced SS tears, which could lead to enhanced CTSS-driven degradation of tear proteins. CTSS against Cys C, LF sIgA was or healthy control Tears from 156 female subjects (33, SS; 33, rheumatoid arthritis; 31, other autoimmune diseases; 35, non-autoimmune dry eye (DE); 24, controls) were analyzed for LF, levels. showed tears...
Category 4 Hurricane Maria made landfall in Puerto Rico on 20 September 2017 and ploughed across the territory with sustained winds of 155 mph. Just two weeks earlier, category 5 Irma had struck island already damaging critical infrastructure making even more devasting. The hurricanes caused catastrophic damage, resulting largest longest response to a domestic disaster history United States. This paper explores recovery process using community resilience lens. study examines narratives,...
Abstract Because of limited free diffusion in the cytoplasm, viruses must use active transport mechanisms to move intracellularly. Nevertheless, how plant single-stranded DNA begomoviruses hijack host intracytoplasmic machinery from nucleus plasmodesmata remains enigmatic. Here, we identified nuclear shuttle protein (NSP)-interacting proteins Arabidopsis (Arabidopsis thaliana) by probing a microarray and demonstrated that cabbage leaf curl virus NSP, facilitator nucleocytoplasmic trafficking...
Although the US FDA encourages manufacturers of medical devices to submit real-world evidence (RWE) support regulatory decisions, ability data (RWD) generate suitable for decision making remains unclear. The 2017 Medical Device User Fee Amendments (MDUFA IV), authorized National Evaluation System health Technology Coordinating Center (NESTcc) conduct pilot projects, or 'Test-Cases', assess whether current RWD captures information needed answer research questions proposed by industry...
Traditional Asian fermented soy food products are associated with reduced cardiovascular disease risk in prospective studies, but few randomized controlled trials have been conducted at-risk populations. The aim of this study was to investigate the effect a commercial non-probiotic product on blood lipids adults biomarkers. In randomized, crossover, intervention study, 27 men and women (aged 29–75 y) exhibiting at least two factors, consumed packets (12.5 g each) daily powdered product, or...
A 48 year-old man, previously in excellent health, presented with several weeks of diffuse pruritus and night sweats as well a cervical mass unresponsive to antibiotics. biopsy the supraclavicular lymph node demonstrated CD30-positive, CD15-negative classical Hodgkin lymphoma (HL), nodular sclerosing subtype (Fig. 1). There was normal cardiac silhouette widened mediastinum on chest X-ray performed at that time 2a,b). staging positron emission tomography/computer tomography (PET/CT) revealed...
Abstract Physical interactions between proteins and other molecules can be evaluated at a proteome scale using protein arrays, type of high‐throughput pulldown assay. We developed modified in situ array known as the nucleic acid programmable assay (NAPPA) that allows screening thousands open reading frames (ORFs) lower cost, with less labor, time than conventional arrays. The HaloTag‐NAPPA efficiently capture expressed on glass slide Halo high‐affinity tag. Here, we describe fabrication...
The authors report extensive peripheral retinoschisis in a patient with stellate nonhereditary idiopathic foveomacular (SNIFR) detected by widefield optical coherence tomography (OCT). A 64-year-old woman diagnosed 3 years prior presented for evaluation after being seen multiple other retina specialists. Standard macular spectral-domain OCT (6 mm) revealed typical schisis involving only the outer retina. However, (12 diffuse bilateral both inner and retinal layers macula midperiphery....
Choroidal nevi are common benign intraocular tumors with a small risk of malignant transformation. This retrospective study investigates the use en face spectral-domain optical coherence tomography angiography (SD-OCTA) in determining clinical features and measurement choroidal nevi.Patients were imaged both OCTA fundus photography device. Greatest longitudinal dimension (GLD), perpendicular (PD), GLD/PD ratio assessed on each Inter-device variation intra- inter-rater reliability analyses...
Before 2011 rates of hospitalization for heart attacks were about the same in San Diego County as they rest California. In a multistakeholder population health collaborative consisting partners at federal, state, and local levels launched Be There Diego. The collaborative's goal was to reduce cardiovascular events through spread best practices aimed improving control hypertension, lipid levels, blood sugar patient medical community activation. Using hospital discharge data period 2007-16, we...
The purpose of this study was to examine the impact a contact-free continuous monitoring system on clinical outcomes including unplanned intensive care unit (ICU) transfer (primary), length stay (LOS), code blue, and mortality. A secondary aim evaluate return investment associated with implementing program during COVID public health emergency.
Abstract Due to limited free diffusion in the cytoplasm, viruses must use active transport mechanisms move intracellularly. Nevertheless, how plant ssDNA begomoviruses hijacks host intracytoplasmic machinery from nucleus plasmodesmata remains enigmatic. Here, we identified nuclear shuttle protein (NSP)-interacting proteins Arabidopsis by probing a microarray and demonstrated that Cabbage leaf curl virus (CabLCV) NSP, facilitator of nucleocytoplasmic trafficking viral (v)DNA, interacts with...
<p>Brugada syndrome is an autosomal dominant disorder, characterized by electrocardiographic manifestations of a pseudo right bundle branch block and distinctive ST segment elevation in the precordial leads, with predisposition to ventricular arrhythmias sudden cardiac arrest. Many medications toxins have been reported induce Brugada pattern on electrocardiogram. We report case patient who presented chest pain was found manifestation type II setting cocaine use pain.</p>