A5049346197- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- 3D Printing in Biomedical Research
- Fuel Cells and Related Materials
- Hippo pathway signaling and YAP/TAZ
- Renal and related cancers
- Microbial Fuel Cells and Bioremediation
- Tissue Engineering and Regenerative Medicine
- Retinal and Macular Surgery
University of California, Santa Barbara
2021-2024
Menlo School
2021-2023
Purpose: To report 1-year follow-up of a phase 1/2a clinical trial testing composite subretinal implant having polarized human embryonic stem cell (hESC)-derived retinal pigment epithelium (RPE) cells on an ultrathin parylene substrate in subjects with advanced non-neovascular age-related macular degeneration (NNAMD) Methods: The included 16 two cohorts. main endpoint was safety assessed at 365 days using ophthalmic and systemic exams. Pseudophakic geographic atrophy (GA) severe vision loss...
Cell-based therapies face challenges, including poor cell survival, immune rejection, and integration into pathologic tissue. We conducted an open-label phase 1/2a clinical trial to assess the safety preliminary efficacy of a subretinal implant consisting polarized monolayer allogeneic human embryonic stem cell-derived retinal pigmented epithelium (RPE) cells in subjects with geographic atrophy (GA) secondary dry age-related macular degeneration. Postmortem histology from one subject very...
The increasing concern about climate change has led scientists around the world to develop clean energy technologies that may replace traditional use of fossil fuels. A promising approach is utilization unicellular organisms as electron donors in bio-fuel cells. To date, this method been limited microorganisms such bacteria, yeast, and microalgae. In work, we show for first time concept using mammalian cell cultures organoids biofuel We apply cyclic voltammetry upon association ARPE19 cells...
Abstract Age-related macular degeneration (AMD) is the primary cause of blindness in adults over 60 years age, and clinical trials are currently assessing therapeutic potential retinal pigmented epithelial (RPE) cell monolayers on implantable scaffolds to treat this disease. However, challenges related culture, long-term storage, long-distance transport such implants limit widespread use adherent RPE cells as therapeutics. Here we report a xeno-free protocol cryopreserve confluent monolayer...
Dry age-related macular degeneration (AMD) is estimated to impact nearly 300 million individuals globally by 2040. While no treatment options are currently available, multiple clinical trials investigating retinal pigmented epithelial cells derived from human pluripotent stem (hPSC-RPE) as a cellular replacement therapeutic underway. It has been that production capacity of >109 RPE annually would be required treat the afflicted population, but current manufacturing protocols limited, being...
Abstract Hypertrophy Cardiomyopathy (HCM) is the most prevalent hereditary cardiovascular disease – affecting >1:500 individuals. Advanced forms of HCM clinically present with hypercontractility, hypertrophy and fibrosis. Several single-point mutations in b-myosin heavy chain (MYH7) have been associated increased contractility at organ level. Different MYH7 resulted increased, decreased, or unchanged force production molecular Yet, how these kinetics link to cell tissue pathogenesis...
The increasing concern about climate change has led scientists around the world to develop clean energy technologies that may replace traditional use of fossil fuels. A promising approach is utilization unicellular organisms as electron donors in bio-fuel cells. To date, this method been limited microorganisms such bacteria, yeast, and microalgae. In work, we show for first time concept using mammalian cell cultures organoids biofuel We apply cyclic voltammetry upon association ARPE19 cells...