A5016869154- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Neuroscience of respiration and sleep
- Alzheimer's disease research and treatments
- Peripheral Artery Disease Management
- Ocular Oncology and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pneumothorax, Barotrauma, Emphysema
- Optical Imaging and Spectroscopy Techniques
- Neonatal and fetal brain pathology
- Peripheral Neuropathies and Disorders
- Retinoids in leukemia and cellular processes
- Cerebrovascular and genetic disorders
- Dermatological diseases and infestations
- Retinal Development and Disorders
- Cerebral Venous Sinus Thrombosis
- Connexins and lens biology
Massachusetts Eye and Ear Infirmary
2018-2022
Harvard University
2018-2022
SUNY Downstate Health Sciences University
2022
Tufts Medical Center
2017-2019
Tufts University
2017-2019
Feinstein Institute for Medical Research
2016
Center for Neurosciences
2016
Introduction Contrast sensitivity function (CSF) may better estimate a patient’s visual compared with acuity (VA). Our study evaluates the quick CSF (qCSF) method to measure in eyes macular disease and good letter acuity. Methods Patients maculopathies (retinal vein occlusion, macula-off retinal detachment, dry age-related degeneration wet degeneration) (VA ≥20/30) were included. The qCSF uses an intelligent algorithm across multiple spatial frequencies. All maculopathy combined individual...
To determine if disorganisation of retinal inner layers (DRIL) is associated with reduced contrast sensitivity (CS) in patients vein occlusion (RVO) a history macular oedema (ME).Prospective, observational cohort study. Patients ME secondary to central (CRVO) or branch (BRVO) from October 2017 July 2019 at single institution were included. underwent complete ophthalmic examination, spectral domain optical coherence tomography (SD-OCT) and CS testing using the quick function (qCSF) method....
To characterize contrast sensitivity function (CSF) in cataractous and pseudophakic eyes compared to healthy control using a novel quantitative CSF test with active learning algorithms.This is prospective observational study at an academic medical center. was measured visually significant cataract, least 2+ nuclear sclerosis (NS) visual acuity (VA) ≥ 20/50, controls no more than 1+ NS complaints, the Manifold Contrast Vision Meter. Outcomes included Area under Log (AULCSF) CS thresholds 1,...
To compare the visualization of choriocapillaris and deeper choroidal vessels in healthy eyes en face swept-source optical coherence tomography (SS-OCT) versus SS-OCT angiography (SS-OCTA).This is a cross-sectional study consecutive without chorioretinal disease. En SS-OCTA images choroid were assessed for vasculature. Choroidal vessel densities (CVD) choriocapillaris, inner choroid, midchoroid, outer calculated from binarized images. Paired t-tests linear regression used statistical...
Objective: To characterize the microvascular retinal changes after repair of macula-off rhegmatogenous detachment (RRD) using optical coherence tomography angiography (OCT-A). Patients and Methods: A retrospective review patients who underwent RRD. Fellow unaffected eyes were used as controls. Post-operative OCT-A allowed comparison vessel density (VD) foveal avascular zone (FAZ) area in superficial deep capillary plexus (DCP) well VD choriocapillaris layer. Results: Seventeen 17 RRD...
To characterize the contrast sensitivity function (CSF) in patients with successful repair of macula-off rhegmatogenous retinal detachment (RD) using an adaptive computerized testing device.CSF was prospectively measured RD following and age-matched controls at W. K. Kellogg Eye Center Massachusetts Ear, employing active learning device Manifold Contrast Vision Meter (Adaptive Sensory Technology, San Diego, CA). Outcome measures included average area under CSF curve (AULCSF), CS thresholds...
Background To characterise the contrast sensitivity function (CSF) in central serous chorioretinopathy (CSCR) compared with healthy controls using novel computerised (CS) testing active learning algorithms. Methods Prospective observational study measuring CSF CSCR eyes and Manifold Platform (Adaptive Sensory Technology, San Diego, California). Mixed effects multivariate regression models were used. Outcomes included area under log (AULCSF), CS thresholds at 1, 1.5, 3, 12 18 cycles per...
BACKGROUND AND OBJECTIVE: To characterize contrast sensitivity function (CSF) in patients with retinal vein occlusion (RVO) compared to age-matched controls using novel computerized (CS) testing active learning algorithms. PATIENTS METHODS: CSF was prospectively measured RVO visual acuity (VA) greater than 20/200 and the Manifold Contrast Vision Meter implementing quantitative testing. Outcomes included area under Log (AULCSF), (CA), CS thresholds at 1, 1.5, 3, 12, 18 cycles per degree...
The American Joint Committee on Cancer 7th edition (AJCC-7) and Brigham Women's Hospital (BWH) staging criteria for cutaneous squamous cell carcinoma (cSCC) have not been validated in immunosuppressed patients.To compare the AJCC-7 BWH systems cSCCs patients.A single-institution retrospective cohort study of patients. Risks local recurrence (LR), nodal metastasis (NM), in-transit metastasis, any poor outcome (PO) were compared among tumor T stages.One hundred six patients had 412 primary...
This article investigates the relationship between visual acuity (VA), total area of geographic atrophy (GA), and percentage foveal GA.A multicenter, retrospective, cross-sectional study was conducted patients with GA due to age-related macular degeneration. Demographics, VA, fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT) images were collected. Using FAF aided by SD-OCT, fovea-sparing status, pattern, size, covering area-within a 1.5-mm-diameter circle...
<h3>Importance</h3> Individuals with autosomal dominant mutations for Alzheimer disease are valuable in determining biomarkers present prior to the onset of cognitive decline, improving ability diagnose as early possible. Optical coherence tomography (OCT) has surfaced a potential noninvasive technique capable analyzing central nervous system tissues disease. <h3>Objective</h3> To evaluate whether OCT can detect retinal alterations carriers presenilin 1 (<i>PSEN1</i>[OMIM104311]) E280A...
Aims The aim of our study was to image choroidal lesions with swept-source optical coherence tomography (SS-OCT) and identify the morphological characteristics associated optimal visualisation. Methods This a prospective, cross-sectional study. Patients melanocytic <3 mm in thickness on B-scan ultrasonography were recruited. All participants underwent SS-OCT. On SS-OCT we evaluated qualitative (eg, lesion outline, detection scleral-choroidal interface quality image) quantitative...
A 60-year-old man with HIV infection presented a 4-month history of lesions on his eyelids and face. Intracytoplasmic eosinophilic inclusion bodies were observed in biopsy specimen, confirming diagnosis molluscum contagiosum.
Purpose: This article describes the clinical and multimodal imaging characteristics of subthreshold exudative choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD). Methods: Among 3773 patients AMD, 8 eyes (6 patients) were identified phenotype interest. Dilated fundus examinations, color photography, fluorescein angiography (FA), indocyanine green (ICGA), optical coherence tomography (OCT), OCT (OCTA) performed. Results: typically showed a moderately...
Immunosuppressed patients have worse outcomes from cutaneous squamous cell carcinomas (cSCCs), although unclear whether it is due to the development of more high-stage tumors or for a given stage.Analyze impact immunosuppression on cSCCs and tumor stage-dependent outcomes.Single-institution 1:2 case-control study primary invasive 2005 2015 in 106 mixed-cause immunosuppressed 212 control subjects matched age, gender, race.Four hundred twelve 291 immunocompetent were included. Both cohorts had...
The rate of Neonatal Abstinence Syndrome (NAS) has drastically increased over the past decade. average hospital expense per NAS patient tripled, while number babies born to opioid-dependent mothers 5 in 1000 births. Current treatment options are limited opioid replacement and tapering. Consequently, we examined efficacy prenatal, low-dose short-term vigabatrin (γ-vinyl GABA, GVG) exposure for attenuating these symptoms as well metabolic changes observed brains animals upon reaching...
A 21-year-old man presented with rigors and right-eye pain swelling after an assault. There was dusky discoloration of the eyelid, decreased visual acuity, elevated intraocular pressure. He underwent surgical débridement, intraoperative findings indicated orbital necrotizing fasciitis.
A 63-year-old healthy woman was referred for a retinal examination. Dilated fundus examination of the left eye revealed small hemorrhage with surrounding exudation, most consistent large microaneurysm, which confirmed by fluorescein angiography and optical coherence tomography (OCT-A). OCT-A has potential to clearly delineate anatomy aneurysms could be used diagnosis surveillance, possibly replacing current gold-standard angiography.
Multiple myeloma (MM) is the second most common hematologic malignancy and primary bone malignancy. Ocular manifestations of MM are extremely rare may be first presentation leading to diagnosis. Ophthalmologists routinely encounter cavernous sinus syndrome, there a wide range possible etiologies. Here, we present case patient presenting with diplopia, ptosis, ophthalmoplegia found have plasmacytoma systemic workup consistent MM. cause syndrome should considered in setting skull base mass.