A5078333939- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Gut microbiota and health
- Ocular Diseases and Behçet’s Syndrome
- Plant Reproductive Biology
- Plant Physiology and Cultivation Studies
- Plant Molecular Biology Research
- Carcinogens and Genotoxicity Assessment
- Plant tissue culture and regeneration
- Invertebrate Immune Response Mechanisms
- Immune Cell Function and Interaction
- Probiotics and Fermented Foods
- Intestinal and Peritoneal Adhesions
- Retinopathy of Prematurity Studies
- Diabetes and associated disorders
- Bioactive Compounds and Antitumor Agents
- Bacterial Identification and Susceptibility Testing
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Genomics, phytochemicals, and oxidative stress
Nagoya University
2015-2024
Kyorin University
2022-2024
Saitama Medical University
2024
Aizawa Hospital
2024
Hyogo University
2024
SBI Pharmaceuticals (Japan)
2021-2023
Tokushima University
2007-2022
Weatherford College
2021
Teikyo University
2021
Harasanshin Hospital
2017-2021
Abstract This multicenter study aimed to assess the short-term effectiveness and safety of faricimab in treatment-naïve patients with wet age-related macular degeneration (wAMD) Japan. We retrospectively reviewed 63 eyes 61 wAMD, including types 1, 2, 3 neovascularization as well polypoidal choroidal vasculopathy (PCV). Patients received three consecutive monthly intravitreal injections loading therapy. Over these months, visual acuity improved gradually compared baseline. Moreover, central...
Although (1→3)-β-d-glucans, which are one of major fungal cell wall components, known to activate invertebrate innate immune systems, their activities on mammalian cells remain elusive. Here, we report mouse macrophages. Among the various curdlan, a linear (1→3)-β-d-glucan, although not branched β-glucans, exhibits significant activity stimulate nuclear factor-κB in The curdlan is dramatically enhanced by pretreatment with sodium hydroxide or dimethyl sulfoxide, disrupts multiple-stranded...
Abstract Detachment of photoreceptors from the retinal pigment epithelium is seen in various disorders, resulting photoreceptor death and subsequent vision loss. Cell results release endogenous molecules that activate molecular platforms containing caspase-1, termed inflammasomes. Inflammasome activation diseases has been reported some cases to be protective others detrimental, causing neuronal cell death. Moreover, cellular source inflammasomes disorders not clear. Here, we demonstrate...
Sorivudine, 1-beta-D-arabinofuranosyl-5-(E)-(2-bromovinyl)uracil, is a potent antiviral agent against varicella-zoster virus and herpes simplex type 1. However, sorivudine should not be used in combination with anticancer drugs such as 5-fluorouracil (5-FU) because (E)-5-(2-bromovinyl)uracil (BVU), metabolite of sorivudine, inhibits the degradation 5-FU, resulting its accumulation blood marked enhancement toxicity 5-FU. Since phosphorolytic enzymes generate BVU from we investigated...
Abstract The role of intestinal bacteria in induction and repression ulcer formation the ileum rats treated with one nonsteroidal antiinflammatory drugs (NSAIDs), 5‐bromo‐2‐(4‐fluorophenyl)‐3‐(4‐methylsulfonylphenyl) thiophene (BFMeT), was examined this study. BFMeT administered by intragastric gavage once at doses 500‐1,500 mg/kg body weight to Wistar without antibiotics (bacitracin, neomycin, streptomycin), germ‐free gnotobiotic rats, 72 hr later their gastrointestinal tracts were for...
To analyze the roles of vitreal macrophages and circulating leukocytes in retinal vascular growth.Bone marrow (BM) cells from green fluorescent protein (GFP) transgenic mice were transplanted into postnatal day (P)1 after irradiation. The exposed to 76% 78% oxygen (P7-P12), initiate oxygen-induced retinopathy (OIR). eyes collected at P8, P17, P30, engraftment GFP-positive retina. peritoneal macrophages, clodronate liposomes, or control liposomes injected P5 P12 examine effects P8 P17. number...
The traditional classification of hypertensive retinopathy was based on the Keith-Wagener-Barker (KWB) grading, which is a subjective scaling system, and it difficult to distinguish between first second grades. Retinal choroidal vasculatures are affected by systemic hypertension, although retinal vasculature changes with age, axial length, intraocular pressure, diseases. It necessary establish new objective method assess vascular changes. In present study, we have examined macular...
To evaluate the potential for mouse genetic background to effect photoreceptor cell death in response experimental retinal detachment (RD).Retinal was induced three inbred strains (C57BL/6, BALB/c, and B6129SF2) by subretinal injection of sodium hyaluronate. A time course assessed TUNEL assay. Total analyzed through comparing outer nuclear layer (ONL)/inner (INL) ratio 7 days post RD. Western blot analysis or quantitative real-time PCR (qPCR) were performed assess signaling, expression...
To evaluate the long-term efficacy and factors involved in recurrence persistence of subretinal fluid (SRF) after half-dose photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSC).In this retrospective observational case series, 79 eyes (73 patients) with CSC were treated PDT followed up at least 3 years. They divided into successful (64 eyes) unsuccessful (15 groups based on SRF absorption disease one session. Age, best-corrected visual acuity (BCVA), foveal thickness,...
Parthenocarpy is a desired trait in tomato because it can overcome problems with fruit setting under unfavorable environmental conditions. A parthenocarpic cultivar, 'MPK-1', gene, Pat-k, exhibits stable parthenocarpy that produces few seeds. Because 'MPK-1' seeds, seedlings are propagated inefficiently via cuttings. It was reported Pat-k located on chromosome 1. However, the gene had not been isolated and relationship between low seed set remained unclear. In this study, we to clarify...
Diabetic retinopathy (DR) is a widespread vision-threatening disease, and neuroretinal abnormality should be considered as an important problem. Brain-derived neurotrophic factor (BDNF) has recently been possible treatment to prevent DR-induced damage, but how BDNF upregulated in DR remains unclear. We found increase hydrogen peroxide (H2O2) the vitreous of patients with DR. confirmed that human retinal endothelial cells secreted H2O2 by high glucose, reduced cell viability MIO-M1, Müller...
Abstract This multicentre retrospective study evaluated the 1-year outcomes and safety profile of faricimab in treatment-naïve patients with neovascular age-related macular degeneration (nAMD). Fifty-five (57 eyes) underwent loading therapy comprising three monthly injections. If dryness was achieved by third month, subsequent treat-and-extend (TAE) follow-up continued at a minimum 8-week interval thereafter. wet macula persisted fourth dose administered, followed TAE regimen. After 1 year,...
We examined the antitumour effect of a combination betulinic acid (BA) and vincristine (VCR) on murine melanoma B16F10 cells in vitro vivo. Betulinic acid, pentacyclic triterpene, showed synergistic cytotoxic by combinational use VCR. VCR induced cell cycle arrest at different points (BA G1 phase G2/M phase) caused apoptosis cells. In vivo study, inhibited metastasis tumour to lung. The addition BA augmented suppression experimental lung C57BL/6 mice. number nodules more than 1 mm diameter...
Nonsteroidal anti-inflammatory drugs (NSAIDs) induced formation of intestinal ulcers as side effects, in which an unbalanced increase the number Gram-negative bacteria small intestine plays important role. To clarify how microflora are influenced by NSAIDs, we examined effects 5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl) thiophene (BFMeT), NSAID, on motility and growth Escherichia coli Lactobacillus acidophilus. Transit index, a marker peristalsis, was not different BFMeT-treated...
Photoreceptor cell death is the definitive cause of vision loss in retinal detachment (RD). Mammalian STE20-like kinase (MST) a master regulator both and proliferation critical factor development tumorigenesis. However, to date role MST neurodegeneration has not been fully explored. Utilizing MST1−/− MST2−/− mice we identified MST2, but MST1, as photoreceptor mouse model RD. demonstrated significantly decreased outer nuclear layer (ONL) thinning after Additionally, caspase-3 activation was...