A5038329890- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Animal Virus Infections Studies
- Viral Infections and Vectors
- Consumer Attitudes and Food Labeling
- Herpesvirus Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Virology and Viral Diseases
- Retinal Imaging and Analysis
- Nutritional Studies and Diet
- Inflammasome and immune disorders
- Retinoids in leukemia and cellular processes
- Heme Oxygenase-1 and Carbon Monoxide
- Ophthalmology and Visual Impairment Studies
- Cerebral Venous Sinus Thrombosis
- Cancer-related molecular mechanisms research
- Traumatic Ocular and Foreign Body Injuries
- Bacteriophages and microbial interactions
- Blood Pressure and Hypertension Studies
- Drug-Induced Ocular Toxicity
- Protein Hydrolysis and Bioactive Peptides
- Retinal and Optic Conditions
Nagoya University
2019-2024
Asahi Breweries (Japan)
2016
Shibuya (Japan)
2011
Diabetic retinopathy (DR) is a widespread vision-threatening disease, and neuroretinal abnormality should be considered as an important problem. Brain-derived neurotrophic factor (BDNF) has recently been possible treatment to prevent DR-induced damage, but how BDNF upregulated in DR remains unclear. We found increase hydrogen peroxide (H2O2) the vitreous of patients with DR. confirmed that human retinal endothelial cells secreted H2O2 by high glucose, reduced cell viability MIO-M1, Müller...
Diabetic macular edema (DME) is characterized by an accumulation of fluid in the macula due to diabetic retinopathy. Currently, anti-VEGF drugs are standard treatment worldwide for DME. This study aimed assess whether existence epiretinal membrane (ERM) affects efficacy, reduced permeability antibody through ERM.We retrospectively examined clinical data DME patients who underwent and evaluated differences existed between eyes with ERM those without ERM. We then created vitro model using...
Purpose: To determine whether caveolin-1 (i) prevents epithelial–mesenchymal transition in the RPE and laser-induced subretinal fibrosis (ii) promotes or inhibits cellular senescence RPE. Methods: We examined cell contraction wild-type Caveolin-1 knockout (Cav-1−/−) mice treated with without cavtratin, a cell-permeable peptide of caveolin-1. The marker p16INK4a was measured tissues from patients geographic atrophy aged mice, fibrosis, primary human cells. Human by TUNEL staining, reactive...
Based on the hypothesis that silicone oil (SO) with a higher refractive index than water induces unexpected vignetting effects during surgeries, we aimed to investigate relationship between volume of SO and light intensity using surgical microscope.Using light-sensitive paper model eye filled varying volumes (0%, 50%, 62.5%, 75%, 87.5% 100%) SO, intraocular lens (IOL) various powers (0, 10 20 dioptres) illuminated by microscope was measured.Light exposure density 1.0% coaxial oblique...
Purpose: Accumulation of the long noncoding Alu element RNA activates NLRP3 inflammasome and leads to retinal pigment epithelium (RPE) cell death, a key event in pathogenesis geographic atrophy during late-stage age-related macular degeneration. Lamivudine (3TC) is nucleoside analog reverse transcriptase inhibitor known inhibit inflammasome. Currently, intracellular response senescence marker p16Ink4a being actively studied. The present study aimed assess efficacy 3TC against RNA-induced RPE...
The purpose of this study is to investigate the protective effect dimethyl fumarate (DMF), methyl-ester fumaric acid, against blue-light (BL) exposure in retinal pigment epithelial (RPE) cells. ARPE-19 cells, a human RPE cell line, were cultured with DMF followed by BL. Reactive oxygen species (ROS) generation, viability, and death rate determined. Real-time polymerase chain reaction Western blotting performed determine change nuclear factor (erythroid-derived)-like 2 (NRF2) expression....
Subsilicone oil fluid (SOF) in eyes with silicone (SO) endotamponade possibly has a role complications (e.g., vision loss); thus, we aimed to examine inflammatory cytokine and electrolyte levels retinal glial cell viability SOF.We measured major electrolytes SOF compared them those vitreous (VF) anterior chamber (ACF). We analyzed the correlation between cytokines thickness SO-filled eyes. Further, MIO-M1 medium it that containing VF.We collected examined 57 SOF, 22 ACF, 21 VF samples from...
Toxoplasmosis is a major infectious disease, affecting approximately one-third of the world's population; its main clinical manifestation, ocular toxoplasmosis (OT), severe sight-threatening disease. Nevertheless, diagnosis OT based on findings, which needs improvement, even with biochemical tests, such as polymerase chain reaction and antibody detections. Furthermore, efficacy OT-targeted treatment limited; thus, additional measures for treatments are needed. Here, we first time report...
Much clinical evidence on the antihypertensive effects of milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro (lactotripeptides) has been reported. However, circadian rhythm determined by ambulatory blood pressure monitoring (ABPM) to eliminate confounding influence white-coat effect have not fully studied. Twelve hypertensive patients receiving medication (2 men, 10 women; mean age±standard deviation, 63.5±8.3 years) who had visiting our clinic for more than 1 year participated in this study....
Abstract Purpose Vitreous humor (VH) is used for postmortem biochemical studies because it well protected in an uncontaminated state even after death. The goal of this research was to investigate electrolyte concentrations the VH from human eyes with and without a history vitrectomy surgery. Methods We analyzed sodium (Na), potassium (K), chloride (Cl) magnesium (Mg) 34 samples patients. Eleven were vitrectomy, remaining 23 had no vitrectomy. correlations Na, K, Cl Mg patient age, interval...
<title>Abstract</title> A newly developed monofocal intraocular lens (IOL), known as Eyhance, features a continuously increasing refractive power from the periphery to center of lens, aiming enhance intermediate vision. Our multicenter prospective, nonrandomized, comparative study in Japan aimed compare outcomes phaco-vitrectomy for epiretinal membrane (ERM) and cataracts using Eyhance (DIB00V) versus conventional (DCB00V). Sixty-two eyes implanted with Tecnis-1 79 were analyzed. While there...
The phenotypes of RP1-related inherited retinal dystrophies (RP1-IRD), causing autosomal dominant (AD) and recessive (AR) diseases, vary depending on specific RP1 variants. A common nonsense mutation near the C-terminus, c.5797 C > T (p.Arg1933*), is associated with RP1-IRD, but exact role this in genotype-phenotype correlation remains unclear. In study, we retrospectively analyzed patients RP1-IRD (N = 42) from a single center Japan. AR 14) mostly displayed macular dystrophy rarely...
Pachyvessels are pathologically dilated large choroidal vessels and associated with the pathogenesis of several pachychoroid-related disorders, including central serous chorioretinopathy. We aimed to investigate prevalence risk factors for pachyvessels in Japanese population. included 316 participants (aged ≥ 40 years) normal right eyes. The presence (vertical diameter > 300 µm, distance retinal pigment epithelium < 50 µm) was determined using 6 × mm macular swept-source optical coherence...
Abstract Importance Torque teno virus positivity in the aqueous humor of uveitis patients could be associated with systemic immunodeficiency. Objective We explored correlation between presence torque and clinical information, including immunodeficiency history. Design This was a retrospective, cross-sectional study. Setting All participants were recruited at Nagoya University Hospital, Tokyo Medical or Yokkaichi Municipal Hospital April 2017 March 2022. Participants The 58 suspected...
Abstract Objective To establish a metagenomic profiling method using long-read sequencing for clinical diagnosis of ocular inflammation and detect the etiologic virus herpetic uveitis. Design A retrospective, cross-sectional study. Participants The participants were 44 uveitis patients with suspected infectious etiology 22 controls cataract. Methods anterior aqueous humor (10-20 µl) was subjected to DNA purification, followed by whole genome amplification. Nanopore MinION™ Flongle Flow Cell...