A5059490403- Autism Spectrum Disorder Research
- Mitochondrial Function and Pathology
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Genetic Neurodegenerative Diseases
- Tissue Engineering and Regenerative Medicine
- Child Nutrition and Feeding Issues
- Genetics and Neurodevelopmental Disorders
- Electromagnetic Fields and Biological Effects
- Magnetic and Electromagnetic Effects
- Neuroendocrine regulation and behavior
- Mesenchymal stem cell research
- Muscle metabolism and nutrition
- Muscle activation and electromyography studies
- Trace Elements in Health
- Cardiac Ischemia and Reperfusion
- Coenzyme Q10 studies and effects
- Tendon Structure and Treatment
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Erythrocyte Function and Pathophysiology
- Pancreatic function and diabetes
- 3D Printing in Biomedical Research
- Advancements in Transdermal Drug Delivery
University of Bologna
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021
Don Carlo Gnocchi Foundation
2013-2021
GNA University
2018
Karolinska Institutet
2009
University of Padua
2009
Neuroscience Institute
2009
University of Florence
2009
University of Chieti-Pescara
2009
Purdue University West Lafayette
2009
It has been suggested that oxidative stress may play a role in the pathogenesis of Autism Spectrum Disorders (ASD), but literature reports somewhat contradictory results. To further investigate issue, we evaluated high number peripheral parameters, and some related issues such as erythrocyte membrane functional features lipid composition. Twenty-one autistic children (Au) aged 5 to 12 years, were gender age-matched with 20 typically developing (TD). Erythrocyte thiobarbituric acid reactive...
Clinical chemistry tests for autism spectrum disorder (ASD) are currently unavailable. The aim of this study was to explore the diagnostic utility proteotoxic biomarkers in plasma and urine, protein glycation, oxidation, nitration adducts, related glycated, oxidized, nitrated amino acids (free adducts), clinical diagnosis ASD. Thirty-eight children with ASD (29 male, 9 female; age 7.6 ± 2.0 years) 31 age-matched healthy controls (23 males, 8 females; 8.6 were recruited study. Plasma adducts...
To define the time course and potential effects of electrical stimulation on permanently denervated muscle, we evaluated excitation-contraction coupling (ECC) rat leg muscles during progression to long-term denervation by ultrastructural analysis, specific binding dihydropyridine receptors, ryanodine receptor 1 (RYR-1), Ca channels extrusion pumps, gene transcription translation Ca-handling proteins, in vitro mechanical properties electrophysiological analyses sarcolemmal passive L-type...
The number of children affected by Autism Spectrum Disorders (ASD) is dramatically increasing as well the studies aimed at understanding risk factors associated with development ASD. Since etiology ASD partly genetic and environmental, (i.e., heavy metals, pesticides) lifestyle seem to have a key role in disease. Control (CTR) children, aged 5-12 years, were compared. Gas chromatography coupled trap mass detector was used measure level 3-PBA, main pyrethroid metabolite urine group patients,...
To assess thiamine and related metabolite status by analysis of plasma urine in autistic children healthy controls, correlations to clinical characteristics link protein markers oxidative damage.27 with autism (21 males 6 females) 21 (15 age-matched control were recruited. The concentration phosphorylated metabolites content dityrosine, N-formylkynurenine 3-nitrotyrosine was determined.Plasma monophosphate concentrations similar both study groups (median [lower-upper quartile]): - 6.60 nM...
// Mariangela Catera 1,* , Vincenzo Borelli Nadia Malagolini 1 Mariella Chiricolo Giulia Venturi Celso A. Reis 2,3,4 Hugo Osorio 2,4 Provvidenza M. Abruzzo Miriam Capri Daniela Monti 5 Rita Ostan Claudio Franceschi and Fabio Dall'Olio Dipartimento di Medicina Specialistica Diagnostica e Sperimentale (DIMES) University of Bologna, Italy 2 Instituto de Investigação Inovação em Saúde (Institute for Research Innovation in Health), Porto, Institute Molecular Pathology Immunology The Porto...
Abstract Background It has been established that children with Autism Spectrum Disorders (ASD) are affected by oxidative stress, the origin of which is still under investigation. In present work, we evaluated inflammatory and pro-oxidant soluble signature in non-syndromic ASD age-matched typically developing (TD) control children. Methods We analyzed leukocyte gene expression cytokines inflammation/oxidative-stress related molecules 21 20 TD Moreover, another—comparable—group (N = 22) 21)...
Following experimental hind limb denervation in rats, this study demonstrates that oxidative stress occurs and advances an hypothesis about its origin. In fact: (i) ROS are formed; (ii) membrane lipids oxidized; (iii) oxidized ion channels pumps may lead to increased [Ca2+]i; all the above mentioned events increase with time. denervated muscle, (iv) mRNA abundance of cytoprotective anti-oxidant proteins (Hsp70, Hsp27, Sod1, Catalase, Gpx1, Gpx4, Gstm1), as well (v) SOD1 enzymatic activity...
Aim of the present work was evaluation effects moderate exercise training on 2 skeletal muscles differing in fibre-type composition, Tibialis Anterior (TA) and Soleus (SOL). Fibre adaptations, including their metabolic shift mechanisms underlying proliferation differentiation, oxidative stress markers, antioxidant cytoprotective molecules, activity Ca<sup>2+</sup>-handling molecules were examined. 6 male 2-month-old rats trained a treadmill for 1 h/day, 3 days/week, 14 weeks, reaching 30...
Among perinatal stem cells of the umbilical cord, human Wharton's jelly mesenchymal (hWJ-MSCs) are great interest for cell-based therapy approaches in regenerative medicine, showing some advantages over other MSCs. In fact, hWJ-MSCs, placed between embryonic and adult MSCs, not tumorigenic harvested with few ethical concerns. Furthermore, these can be easily cultured vitro, maintaining both properties a high proliferative rate several passages, as well trilineage capacity differentiation....
Physical exercise is deemed the most efficient way of counteracting age-related decline skeletal muscle. Here we report a transcriptional study by next-generation sequencing vastus lateralis biopsies from elderly with life-long high-level training practice (n = 9) and age-matched sedentary subjects 5). Unsupervised mixture distribution analysis was able to correctly categorize trained untrained subjects, whereas it failed discriminate between individuals who underwent prevalent endurance 5)...
BackgroundExposure to intermittent hypoxia (IH) may enhance cardiac function and protects heart against ischemia-reperfusion (I/R) injury. To elucidate the underlying mechanisms, we developed a cardioprotective IH model that was characterized at hemodynamic, biochemical molecular levels. MethodsMice were exposed 4 daily cycles (each composed of 2-min 6-8% O2 followed by 3-min reoxygenation for 5 times) 14 days, with normoxic mice as controls. Mice then anesthetized subdivided in various...
Membranes attract attention in medicine, concerning lipidome composition and fatty acid correlation with neurological diseases. Hyperspectral dark field microscopy (HDFM), a biophotonic imaging using reflectance spectra, provides accurate characterization of healthy adult RBC identifying library 8 spectral end-members. Here we report hyperspectral children affected by Autism Spectrum Disorder (ASD) (n = 21) compared to age-matched subjects 20), investigating if statistically significant...
In a previous study, the whole transcriptome of vastus lateralis muscle from sedentary elderly and age-matched athletes with an exceptional record high-intensity, life-long exercise training was compared—the two groups representing extremes on physical activity scale. Exercise enabled skeletal to counteract age-related sarcopenia by inducing wide range adaptations, sustained expression protein-coding genes involved in energy handling, proteostasis, cytoskeletal organization, inflammation...
Red blood cells (RBCs) from people affected by autism spectrum disorders (ASDs) are a target of oxidative stress. By scanning electron microscopy, we analyzed RBC morphology 22 ASD children and show here that only 47.5 ± 3.33% displayed the typical biconcave shape, as opposed to 87.5 1.3% (mean SD) 21 sex- age-matched healthy typically developing (TD) controls. Codocytes star-shaped accounted for about 30% all abnormally shaped erythrocytes. shape alterations were independent anticoagulant...
Na + , K ‐ATPase (NKA) activity, which establishes the sodium and potassium gradient across cell membrane is instrumental in propagation of nerve impulses, altered a number neurological neuropsychiatric disorders, including autism spectrum disorders (ASD). In present work, we examined wide range biochemical cellular parameters attempt to understand reason(s) for severe decrease NKA activity erythrocytes ASD children that reported previously. leukocytes was found be decreased independently...
Cytoskeletal proteins provide architectural and signaling cues within cells. They are able to reorganize themselves in response mechanical forces, converting the stimuli received into specific cellular responses. Thus, cytoskeleton influences cell shape, proliferation, even differentiation. In particular, affects fate of mesenchymal stem cells (MSCs), which highly attractive candidates for therapy approaches due their capacity self-renewal multi-lineage Cytochalasin B (CB), a cyto-permeable...