A5091028194- Autism Spectrum Disorder Research
- Mitochondrial Function and Pathology
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Tendon Structure and Treatment
- Muscle Physiology and Disorders
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- PARP inhibition in cancer therapy
- Sulfur Compounds in Biology
- Muscle metabolism and nutrition
- Child Nutrition and Feeding Issues
- Sports injuries and prevention
- Cardiac Ischemia and Reperfusion
- Genetics and Physical Performance
- Trace Elements in Health
- Muscle activation and electromyography studies
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Shoulder Injury and Treatment
- Genetic Neurodegenerative Diseases
- Cancer, Hypoxia, and Metabolism
- Sports Performance and Training
- Acute Myeloid Leukemia Research
University of Bologna
2014-2023
Don Carlo Gnocchi Foundation
2013-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2021
GNA University
2018
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2017
University of Florence
2001-2016
University of Padua
2009-2015
Neuroscience Institute
2009
University of Chieti-Pescara
2009
Purdue University West Lafayette
2009
It has been suggested that oxidative stress may play a role in the pathogenesis of Autism Spectrum Disorders (ASD), but literature reports somewhat contradictory results. To further investigate issue, we evaluated high number peripheral parameters, and some related issues such as erythrocyte membrane functional features lipid composition. Twenty-one autistic children (Au) aged 5 to 12 years, were gender age-matched with 20 typically developing (TD). Erythrocyte thiobarbituric acid reactive...
Clinical chemistry tests for autism spectrum disorder (ASD) are currently unavailable. The aim of this study was to explore the diagnostic utility proteotoxic biomarkers in plasma and urine, protein glycation, oxidation, nitration adducts, related glycated, oxidized, nitrated amino acids (free adducts), clinical diagnosis ASD. Thirty-eight children with ASD (29 male, 9 female; age 7.6 ± 2.0 years) 31 age-matched healthy controls (23 males, 8 females; 8.6 were recruited study. Plasma adducts...
Nowadays, no data are available concerning the potential use of dual cyclooxygenase (COX)/5-lipoxygenase (LOX) inhibitors as anticancer agents in colon cancer treatment. Here, we report, for first time, that COX/5-LOX inhibitor licofelone triggers apoptosis a dose- and time-dependent manner HCA-7 cells. Induction was related to recruitment intrinsic mitochondrial apoptotic pathway, shown by loss membrane potential, cytochrome c release, caspase-9 3 activation poly-(ADP-ribose)polymerase-1...
A set of eight proteins is induced in peripheral blood lymphocytes from normal donors by exposure to hydrogen peroxide or xanthine oxidase plus hypoxanthine. Four them (hsp90, hsp72 and 65 50 kDa) are also expressed after heat shock, together with 110, 100 38 kDa. Among oxidative stress a 32 kDa protein-probably corresponding heme oxygenase-1 (HO-1)- 27 protein, both known be reactive oxygen species. Although ionizing radiation generate number pro-oxidant intermediates, using our...
Abstract Background Despite the great advances in understanding of programmed cell death, little attention has been paid to sequence events that characterise it. In particular, course apoptotic induced by microtubule-interfering agents such as taxanes is poorly understood. order increase knowledge, we studied a number independent biochemical and cytological modifications using cytometric methods bladder cancer line treated with second generation taxane, docetaxel. Results Within few hours,...
To define the time course and potential effects of electrical stimulation on permanently denervated muscle, we evaluated excitation-contraction coupling (ECC) rat leg muscles during progression to long-term denervation by ultrastructural analysis, specific binding dihydropyridine receptors, ryanodine receptor 1 (RYR-1), Ca channels extrusion pumps, gene transcription translation Ca-handling proteins, in vitro mechanical properties electrophysiological analyses sarcolemmal passive L-type...
Aim of the present work was evaluation effects moderate exercise training on 2 skeletal muscles differing in fibre-type composition, Tibialis Anterior (TA) and Soleus (SOL). Fibre adaptations, including their metabolic shift mechanisms underlying proliferation differentiation, oxidative stress markers, antioxidant cytoprotective molecules, activity Ca<sup>2+</sup>-handling molecules were examined. 6 male 2-month-old rats trained a treadmill for 1 h/day, 3 days/week, 14 weeks, reaching 30...
The number of children affected by Autism Spectrum Disorders (ASD) is dramatically increasing as well the studies aimed at understanding risk factors associated with development ASD. Since etiology ASD partly genetic and environmental, (i.e., heavy metals, pesticides) lifestyle seem to have a key role in disease. Control (CTR) children, aged 5-12 years, were compared. Gas chromatography coupled trap mass detector was used measure level 3-PBA, main pyrethroid metabolite urine group patients,...
To assess thiamine and related metabolite status by analysis of plasma urine in autistic children healthy controls, correlations to clinical characteristics link protein markers oxidative damage.27 with autism (21 males 6 females) 21 (15 age-matched control were recruited. The concentration phosphorylated metabolites content dityrosine, N-formylkynurenine 3-nitrotyrosine was determined.Plasma monophosphate concentrations similar both study groups (median [lower-upper quartile]): - 6.60 nM...
Abstract Background It has been established that children with Autism Spectrum Disorders (ASD) are affected by oxidative stress, the origin of which is still under investigation. In present work, we evaluated inflammatory and pro-oxidant soluble signature in non-syndromic ASD age-matched typically developing (TD) control children. Methods We analyzed leukocyte gene expression cytokines inflammation/oxidative-stress related molecules 21 20 TD Moreover, another—comparable—group (N = 22) 21)...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransfer ribonucleic acids in rat liver and Morris 5123 minimal deviation hepatomaFabio Gonano, Vincenzo P. Chiarugi, Giuseppe Pirro, Marina MariniCite this: Biochemistry 1971, 10, 5, 900–908Publication Date (Print):March 1, 1971Publication History Published online1 May 2002Published inissue 1 March 1971https://doi.org/10.1021/bi00781a027RIGHTS & PERMISSIONSArticle Views15Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the...
Following experimental hind limb denervation in rats, this study demonstrates that oxidative stress occurs and advances an hypothesis about its origin. In fact: (i) ROS are formed; (ii) membrane lipids oxidized; (iii) oxidized ion channels pumps may lead to increased [Ca2+]i; all the above mentioned events increase with time. denervated muscle, (iv) mRNA abundance of cytoprotective anti-oxidant proteins (Hsp70, Hsp27, Sod1, Catalase, Gpx1, Gpx4, Gstm1), as well (v) SOD1 enzymatic activity...
Different conditions may alter tendon characteristics. Clinical evidence suggests that injuries are more frequent in athletes change type, intensity and duration of training. Aim the study was assessment training especially detraining on patellar (PT) its enthesis.27 male adult Sprague-Dawley rats were divided into 3 groups: 20 trained a treadmill for 10 weeks. Of these, euthanized immediately after (trained group), caged without exercise 4 weeks before being (de-trained group). The...
The physio-pathologic interrelationships between endothelium and GvHD have been better elucidated led to definition of the entity 'endothelial GvHD' as an essential early phase prior clinical presentation acute GvHD. Using CellSearch system, we analyzed circulating endothelial cells (CEC) in 90 allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients at following time-points: T1 (pre-conditioning), T2 (pre-transplant), T3 (engraftment), T4 (onset GvHD) T5 (1 week after steroid...
BACKGROUND: After the removal of buffy coat, packed red cell (RBC) transfusion units still contain white cells that may undergo apoptosis as a result storage conditions (1‐6 degrees C). The aim present study was evaluation this phenomenon in view possible influence it have on febrile nonhemolytic reactions. STUDY DESIGN AND METHODS: Three independent methods (microscopy, DNA electrophoresis, and cytometry) were used to evaluate 13 RBC units. Of these units, 10 had been collected into...
Myotendinous junctions can be easily injured by overloading or trauma, and exercise training may a way of increasing their resistance to mechanical stress. To this end, we examined herein the morphological changes induced moderate in myotendinous extensor digitorum longus gastrocnemius muscles rats. Twelve Sprague-Dawley rats were used investigation. Six them trained run on treadmill for 1 h/day, 3 days/week over 10 weeks order achieve running rate 25 m/min at end period. age-matched...
Physical exercise is deemed the most efficient way of counteracting age-related decline skeletal muscle. Here we report a transcriptional study by next-generation sequencing vastus lateralis biopsies from elderly with life-long high-level training practice (n = 9) and age-matched sedentary subjects 5). Unsupervised mixture distribution analysis was able to correctly categorize trained untrained subjects, whereas it failed discriminate between individuals who underwent prevalent endurance 5)...
BackgroundExposure to intermittent hypoxia (IH) may enhance cardiac function and protects heart against ischemia-reperfusion (I/R) injury. To elucidate the underlying mechanisms, we developed a cardioprotective IH model that was characterized at hemodynamic, biochemical molecular levels. MethodsMice were exposed 4 daily cycles (each composed of 2-min 6-8% O2 followed by 3-min reoxygenation for 5 times) 14 days, with normoxic mice as controls. Mice then anesthetized subdivided in various...