A5071965992- Pesticide Exposure and Toxicity
- Diet and metabolism studies
- Hemoglobin structure and function
- Environmental Toxicology and Ecotoxicology
- Nutrition, Genetics, and Disease
- Nuclear Receptors and Signaling
- Adipose Tissue and Metabolism
- Marine Biology and Environmental Chemistry
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Erythrocyte Function and Pathophysiology
- Trace Elements in Health
- Mitochondrial Function and Pathology
- Insect and Pesticide Research
- RNA modifications and cancer
- Edible Oils Quality and Analysis
- Neuroscience and Neuropharmacology Research
- Heavy Metal Exposure and Toxicity
- Medicinal Plants and Neuroprotection
- Child Nutrition and Water Access
- Nigella sativa pharmacological applications
- Gut microbiota and health
- Physiological and biochemical adaptations
- Biochemical effects in animals
- Immunotoxicology and immune responses
Università di Camerino
2016-2025
Institución Universitaria Colombo Americana
2010-2011
Universidad Católica Redemptoris Mater
2010-2011
Network of the Universities from the Capitals of Europe
2010-2011
Universidad Católica Cecilio Acosta
2010-2011
Istituto di Farmacologia Traslazionale
2005
University of Rome Tor Vergata
1997-1999
Ospedali Riuniti di Ancona
1993-1999
The oil obtained from the seeds of Nigella sativa L. (N. sativa), also known as black cumin, is frequently used in Mediterranean area for its anti-inflammatory, anti-oxidant, and anti-cancer activities. aim present study was to evaluate antioxidant anti-inflammatory properties extracted a N. cultivar produced Marche region Italy, determine if thymoquinone content, properties, biological activity would decay during storage. Cytotoxicity were tested an vitro model low-grade inflammation...
This study investigated the preventive efficacy of crude oil extracted from Nigella sativa seeds in a rat model arthritis induced by using complete Freund's adjuvant (CFA). at 1.82 mL/kg or 0.91 (corresponding to 1596 and 798 mg/kg, respectively) was orally administered for 25 days day immunization. One immunized group treated with indomethacin (3 mg/kg) as reference drug. Body weight growth rate, paw swelling, score, mechanical allodynia, locomotor activity anxiety-like behavior were...
Mitophagy has a pivotal protective function in the pathogenesis of neurological disorders. However, mechanism its modulation remains elusive, especially PINK1-mediated mitophagy. Here, we investigated neuroprotective effects walnut-derived peptide, YVLLPSPK, against scopolamine-induced cognitive deficits mice and explored underlying mitophagy mechanisms H2O2-treated HT-22 cells. Using Morris water maze, showed that YVLLPSPK relieved deficiency by alleviating oxidative stress. Mitochondrial...
l-carnitine supplementation has been used for cardiovascular health protection a long time. Recently, trimethylamine-N-oxide (TMAO), which is an end product of metabolism via the activity microbiota, identified as disease (CVD) biomarker. The aim this study was to assess effect 6 months in group aged women engaged regular physical training. Platelet mitochondrial DNA methylation, emerging and innovative biomarker, lipid profile TMAO levels have measured. increased after (before 344.3 ± 129.8...
During the neurodevelopmental period, brain is potentially more susceptible to environmental exposure pollutants. The aim was determine if neonatal permethrin (PERM) pesticide, at a low dosage that does not produce signs of obvious abnormalities, could represent risk for onset diseases later in life.Neonatal rats (from postnatal day 6 21) were treated daily by gavage with dose PERM (34 mg/kg) close no-observed-adverse-effect level (NOAEL), and hippocampal morphology function synapses...
The number of children affected by Autism Spectrum Disorders (ASD) is dramatically increasing as well the studies aimed at understanding risk factors associated with development ASD. Since etiology ASD partly genetic and environmental, (i.e., heavy metals, pesticides) lifestyle seem to have a key role in disease. Control (CTR) children, aged 5-12 years, were compared. Gas chromatography coupled trap mass detector was used measure level 3-PBA, main pyrethroid metabolite urine group patients,...
Environmental exposure to pesticides during the early stages of development represents an important risk factor for onset neurodegenerative diseases in adult age. Neonatal Permethrin (PERM), a member family synthetic pyrethroids, can induce Parkinson-like disease and cause some alterations striatum rats, involving both genetic epigenetic pathways. Through gene expression analysis global DNA methylation assessment PERM-treated parents their untreated offspring, we investigated on prospective...