A5067837276- Lipid Membrane Structure and Behavior
- Cellular Mechanics and Interactions
- Antimicrobial Peptides and Activities
- Tissue Engineering and Regenerative Medicine
- Occupational and environmental lung diseases
- Force Microscopy Techniques and Applications
- RNA Research and Splicing
- Streptococcal Infections and Treatments
- Neuroscience and Neural Engineering
- Biofield Effects and Biophysics
- Experimental Learning in Engineering
- Polydiacetylene-based materials and applications
- Molecular Biology Techniques and Applications
- Tendon Structure and Treatment
- Radioactivity and Radon Measurements
- Genetics and Neurodevelopmental Disorders
- Biomedical and Engineering Education
- Erythrocyte Function and Pathophysiology
- Microfluidic and Capillary Electrophoresis Applications
- Stellar, planetary, and galactic studies
- Bone Tissue Engineering Materials
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- RNA modifications and cancer
University of Modena and Reggio Emilia
2018-2025
Istituto Nanoscienze
2019-2024
El.En. Group (Italy)
2024
University of Trieste
2013
Aberrant splicing events are associated with colorectal cancer (CRC) and provide new opportunities for tumor diagnosis treatment. The expression of the splice variants NF-YA, DNA binding subunit transcription factor NF–Y, is deregulated in multiple types compared to healthy tissues. NF–YAs NF–YAl isoforms differ transactivation domain, which may result distinct transcriptional programs. In this study, we demonstrated that transcript higher aggressive mesenchymal CRCs predicts shorter...
Glioblastoma multiforme (grade IV glioma) is characterized by a high invasive potential, making surgical intervention extremely challenging and patient survival very limited. Current pharmacological approaches show, at best, slight improvements in the therapy against this type of tumor. Microtubules are often target antitumoral drugs, specific drugs affecting their dynamics acting on microtubule-associated proteins (MAPs) without producing depolymerization could affect both glioma cell...
As a contribution to the study of habitability extrasolar planets, we implemented 1-D Energy Balance Model (EBM), simplest seasonal model planetary climate, with new prescriptions for most physical quantities. Here apply our EBM investigate surface planets an Earth-like atmospheric composition but different levels pressure. The habitability, defined as mean fraction planet's on which liquid water could exist, is estimated from pressure-dependent temperature range, taking into account and...
Among perinatal stem cells of the umbilical cord, human Wharton's jelly mesenchymal (hWJ-MSCs) are great interest for cell-based therapy approaches in regenerative medicine, showing some advantages over other MSCs. In fact, hWJ-MSCs, placed between embryonic and adult MSCs, not tumorigenic harvested with few ethical concerns. Furthermore, these can be easily cultured vitro, maintaining both properties a high proliferative rate several passages, as well trilineage capacity differentiation....
Daptomycin (DAP) is a calcium-dependent cyclic lipopeptide with great affinity for negatively charged phospholipids bearing the phosphatidylglycerol (PG) headgroup and has been used since 2003 as last resort antibiotic in treatment of severe infections caused by Gram-positive bacteria. The first step its mechanism action involves interaction bacterial membrane, which not only represents physical barrier but also accommodates transmembrane proteins, such receptors, transporters, enzymes,...
In recent years the possibility of observing by microscopy dynamic activity living cells has been largely pursued. We have developed a low-cost (~ 260 euros) on-stage cell incubator for inverted optical microscopes. This device allows to keep in good conditions their survival and proliferation. The is based on use Arduino microprocessor interfaced with LabView. It can be connected computer via USB port allowing monitor register all useful parameters measurements: temperature, CO2...
Cytoskeletal proteins provide architectural and signaling cues within cells. They are able to reorganize themselves in response mechanical forces, converting the stimuli received into specific cellular responses. Thus, cytoskeleton influences cell shape, proliferation, even differentiation. In particular, affects fate of mesenchymal stem cells (MSCs), which highly attractive candidates for therapy approaches due their capacity self-renewal multi-lineage Cytochalasin B (CB), a cyto-permeable...
ABSTRACT Mutations of the cyclin-dependent kinase-like 5 (CDKL5) gene, which encodes a serine/threonine protein kinase, can cause CDKL5 deficiency disorder (CDD), severe neurodevelopmental disease characterized by epileptic encephalopathy and neurocognitive impairment. The kinase consists catalytic N-terminal domain (NTD) less C-terminal (CTD). Numerous disease-related mutations truncate CDKL5, leaving NTD intact while variably shortening CTD, highlights importance CTD for function. By...
<p>Although in the last 30 years mineral fibres have been subject of intensive toxicological studies, actual mechanisms by which exert cytotoxic activity are not fully understood. In this scenario, our work focuses on monitoring very early steps interaction between chrysotile, crocidolite and erionite (classified as carcinogenic International Agency for Research Cancer) macrophages using time-lapse video microscopy coupled with <em>in vitro</em>...