A5088666492- Neuroscience and Neuropharmacology Research
- GABA and Rice Research
- Diet and metabolism studies
- Fatty Acid Research and Health
- Epilepsy research and treatment
- Liver Disease and Transplantation
- Metabolism and Genetic Disorders
- Nuts composition and effects
- Medicinal Plants and Neuroprotection
- Liver Disease Diagnosis and Treatment
- Biochemical Analysis and Sensing Techniques
- Cholinesterase and Neurodegenerative Diseases
- Phytoestrogen effects and research
- Neuroinflammation and Neurodegeneration Mechanisms
- Hops Chemistry and Applications
- Occupational and environmental lung diseases
- Mitochondrial Function and Pathology
- Sleep and Wakefulness Research
- Alcoholism and Thiamine Deficiency
- Phosphodiesterase function and regulation
- Cannabis and Cannabinoid Research
- Peroxisome Proliferator-Activated Receptors
- Horticultural and Viticultural Research
- Antioxidant Activity and Oxidative Stress
- Migraine and Headache Studies
University of Modena and Reggio Emilia
2009-2024
University of Virginia
1998
Amsterdam UMC Location University of Amsterdam
1998
A nutritional approach could be a promising strategy to prevent or slow the progression of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease, since there is no effective therapy for these so far. The beneficial effects omega-3 fatty acids are now well established by plethora studies through their involvement in multiple biochemical functions, including synthesis antinflammatory mediators, cell membrane fluidity, intracellular signalling gene...
Many reports have shown promising beneficial effects of long-chain polyunsaturated fatty acids (L-PUFAs) the omega 3 series in several brain diseases. In present study, we tested hypothesis that supplement reduced pro-inflammatory functions vitro and vivo. We demonstrated a rich PUFAs (SRP) increased cell viability dose-dependent manner suggesting its protective role against lipopolysaccharide (LPS)-induced death BV2 microglial line. same cultures, reactive oxygen species (ROS) nitric oxide...
Neuroinflammation, whose distinctive sign is the activation of microglia, supposed to play a key role in development and progression neurodegenerative diseases. The aim this investigation was determine levels neurosteroids produced by resting injured BV-2 microglial cells. cells were exposed increasing concentrations rotenone progressively reduce their viability reactive oxygen species (ROS) production. cell significantly reduced 24, 48 72 h after (50–1000 nM) exposure. Concomitantly,...
We obtained evidence that mouse BV2 microglia synthesize neurosteroids dynamically to modify neurosteroid levels in response oxidative damage caused by rotenone. Here, we evaluated whether could be produced and altered rotenone the human microglial clone 3 (HMC3) cell line. To this aim, HMC3 cultures were exposed (100 nM) measured culture medium liquid chromatography with tandem mass spectrometry. Microglia reactivity was measuring interleukin 6 (IL-6) levels, whereas viability monitored...
Produced by the mitochondria and endoplasmic reticulum, neurosteroids such as allopregnanolone are neuroprotective molecules that influence various neuronal functions regulate neuroinflammation. They reduced in neurodegenerative diseases, while Wobbler mouse model, its precursor progesterone showed protective effects on motor neuron degeneration. This single-center case-control study included 37 patients with amyotrophic lateral sclerosis (ALS) 28 healthy controls. Cerebrospinal fluid (CSF)...
A nutritional approach could be a promising strategy to prevent or decrease the progression of neurodegenerative disorders such as Parkinson’s disease (PD). The neuroprotective role walnut oil (WO) was investigated in Drosophila melanogaster treated with rotenone (Rot), PD model, WO, their combination, and compared controls. WO reduced mortality improved locomotor activity impairment after 3 7 days, induced by Rot. LC-MS analyses fatty acid levels heads showed significant increase linolenic...
Background/Aim —Despite some controversy, it has been suggested that endogenous benzodiazepine plays a role in the pathogenesis of hepatic encephalopathy. The aim present study was to evaluate concentrations benzodiazepines and peptide, diazepam binding inhibitor, blood patients with liver cirrhosis without overt encephalopathy, compare these levels those consumers commercial benzodiazepines. Subjects —Normal subjects (90), (14), cirrhotic (113) were studied. Methods —Endogenous measured by...
In the present study we investigate behavioural effects of β-asarone, main compound essential oil obtained from Acorus calamus. when administered intraperitoneally in rats, exerts sedative and hypothermic but not analgesic effects. however, association with cannabinomimetic drug WIN 55,212-2, was shown to potentiate some typical activities induced animals by cannabinoids. Binding assays, performed on cortical synaptic membrane preparations using a specific cannabinoid radioligand...
The effect of flaxseed oil rich in linolenic acid (ALA), and a mixed (flaxseed fish oil) eicosapentaenoic (EPA) docosahexaenoic (DHA), on the lipid clearance peroxisome proliferator activated receptors (PPARs) liver adipose tissue rats fed for 30 days with two oils was evaluated. results showed that after treatment hematic triacylglycerol content significantly decreased compared to control animals. Regarding distribution major omega-3 fatty acids, both were able increase ALA, EPA,...
Asbestos is a commercial term indicating six natural silicates with asbestiform crystal habit. Of these, five are double-chain (amphibole) and one layer silicate (serpentine asbestos or chrysotile). Although all species classified as human carcinogens, their degree of toxicity still matter debate. Amphibole biopersistent in the lungs exert chronic toxic action for decades, whereas chrysotile not transforms into an amorphous silica structure prone to chemical/physical clearance when exposed...