Giovanni Vitale
A5079443706- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Anesthesia and Pain Management
- Liver Diseases and Immunity
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Neuroendocrine Tumor Research Advances
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Anesthesia and Sedative Agents
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Hernia repair and management
- Cardiac Arrest and Resuscitation
- Cytokine Signaling Pathways and Interactions
- Drug-Induced Hepatotoxicity and Protection
- Cancer Immunotherapy and Biomarkers
- Pituitary Gland Disorders and Treatments
- Airway Management and Intubation Techniques
University of Milan
1991-2025
IRCCS Istituto Auxologico Italiano
1999-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2025
Azienda USL di Bologna
2020-2025
IRCCS Policlinico San Donato
1994-2024
Centre Hospitalier Universitaire de Besançon
2024
University of Bologna
2013-2023
Policlinico S.Orsola-Malpighi
2014-2023
ERN RARE-LIVER
2023
Ospedale San Carlo
2019-2023
Ten patients with parenchymal acute respiratory failure (ARF) underwent computed tomography (CT) scans while in the supine and prone positions. At equal levels of positive end-expiratory pressure, authors measured changes CT density dorsal ventral basilar lung regions induced by change position as well alterations gas exchange. The level venous admixture did not body position. scan image each was fractionated into ten from to ventral, constituting 10% height. After measuring fraction,...
We obtained chest computed tomography (CT) sections in 12 normal subjects (controls) and 17 patients with the adult respiratory distress syndrome (ARDS) to investigate regional lung inflation. A basal CT section (just above diaphragm) was supine position at zero cm H2O end-expiratory pressure. In each distance from ventral dorsal surface (hT) divided into 10 equal intervals, levels (no. 1) 10) were defined. Knowing average density volume of level, we computed: (1) tissue volume; (2)...
BackgroundCoronavirus disease 2019 (COVID-19) is associated with a high burden 10% of confirmed cases progressing towards critical illness. Nevertheless, the course and predictors mortality in critically ill patients are poorly understood.MethodsFollowing developments ICUs regions experiencing early inception pandemic, European-based, international RIsk Stratification COVID-19 Intensive Care Unit (RISC-19-ICU) registry was created to provide near real-time assessment developing illness due...
Rationale: Treatment with noninvasive ventilation (NIV) in coronavirus disease (COVID-19) is frequent. Shortage of intensive care unit (ICU) beds led clinicians to deliver NIV also outside ICUs. Data about the use COVID-19 limited.Objectives: To describe prevalence and clinical characteristics patients treated investigate factors associated failure (need for intubation or death).Methods: In this prospective, single-day observational study, we enrolled adult who were ICU from 31 hospitals...
Hepatocellular carcinoma (HCC) represents the second leading cause of cancer deaths worldwide. Six-month imaging along with alpha-fetoprotein (AFP) serum levels detection are current gold standard to exclude HCC. Protein induced by vitamin K absence (PIVKA-II) has been proposed as a potential screening biomarker for This study was designed evaluate role PIVKA-II diagnostic HCC marker, and correlation between stage. were assessed on samples Italian patients. The population included 80...
Summary The availability of direct‐acting antiviral agents ( DAA ) regimens has expanded the pool patients eligible for treatment. However, data on virologic response and tolerability s in elderly are lacking. We evaluated efficacy safety with advanced fibrosis/cirrhosis real‐life practice focus those aged ≥65 years. Between January December 2015, all consecutive HCV ‐related treated at eleven tertiary referral centres Emilia Romagna (Italy) were enrolled. Regimen choice was based viral...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in solid organ transplant (SOT) recipients is associated with poorer antibody response (AbR) compared non-SOT recipients. However, its impact on the risk of breakthrough infection (BI) has yet to be assessed. Methods Single-center prospective longitudinal cohort study enrolling adult SOT who received SARS-CoV-2 during a 1-year period (February 2021 – January 2022), end follow-up April 2022. Patients...
BACKGROUND Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor derived from parafollicular cells. At present, surgery the most important treatment for MTC. METHODS We describe current approaches of MTC (surgery, chemotherapy, radiation therapy, and biologic therapy). RESULTS currently approached surgically in main part through total thyroidectomy compartment-oriented microdissection cervicomediastinal lymph nodes. Substitutive l-thyroxine administration together with close clinical...
Skeletal metastases from thyroid cancer are poorly responsive to medical or radioiodine treatment. Bone destruction in skeletal results osteoclast-induced bone resorption. Therefore, a new approach the therapy of consists using aminobisphosphonates, such as pamidronate, which potent inhibitors osteoclastic activity. In present study, 10 patients with painful osteolytic were administered pamidronate (90 mg, 2 hour intravenous infusion) monthly for 12 consecutive cycles. pain, quality life,...
Pulsed tissue Doppler (TD) is a new ultrasound tool that allows quantification of myocardial regional wall motion. To investigate the cardiac effects subclinical hypothyroidism (SH), present study assessed left ventricular (LV) function in SH by pulsed TD. Twenty women with and 20 healthy underwent standard echocardiograms TD, placing sample volume at level posterior septum LV mitral annulus. Myocardial systolic diastolic velocities time intervals were determined for both levels....
We evaluated the role of type I interferons (IFNs) and IFN receptors in regulation cell growth 3 human pancreatic adenocarcinoma lines (BxPC-3, MiaPaCa-2, Panc-1).Chemotherapy radiotherapy have a marginal management adenocarcinoma. The addition IFN-alpha showed promising results early clinical trials.Cell proliferation apoptosis were by DNA measurement fragmentation, respectively. Type receptor (IFNAR-1 IFNAR-2 subunits) was determined quantitative RT-PCR immunocytochemistry. Cell cycle...
Introduction. Host lipid metabolism influences viral replication and lifecycle of hepatitis C virus. Our aim was to evaluate changes in glucose patients with chronic after therapy direct acting antivirals (DAA). Material methods. We considered consecutively treated between January November 2015 recording clinical data at baseline week 24 follow-up. Frozen serum samples were used for apolipoprotein A1 (apoA1), B (apoB) lipoprotein (a) [Lp(a)]. Wilcoxon test utilized estimate trends Logistic...
A nutritional approach could be a promising strategy to prevent or slow the progression of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease, since there is no effective therapy for these so far. The beneficial effects omega-3 fatty acids are now well established by plethora studies through their involvement in multiple biochemical functions, including synthesis antinflammatory mediators, cell membrane fluidity, intracellular signalling gene...
A Covid-19 outbreak developed in Lombardy, Veneto and Emilia-Romagna (Italy) at the end of February 2020. Fear an imminent saturation available ICU beds generated notion that rationing intensive care resources could have been necessary.In order to evaluate impact on capacity manage critically ill patients, we performed a retrospective analysis first 2 weeks (February 24-March 8). Data were collected from regional registries case report form sent participating sites. increased 1545 1989...
There is growing evidence that liver transplantation (LT) the most effective treatment for acute-on-chronic failure grade-3 (ACLF-3). This study examines whether and how this translates into practice by analyzing variability in intensive care unit (ICU) admissions, listing strategies, LT activity patients with ACLF-3 across centers Europe. Consecutive who were admitted to ICU ACLF-3, or not they listed and/or transplanted between 2018 2019 included 20 centers. A total of 351 included: 33 had...