A5015791478- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Radar Systems and Signal Processing
- Congenital Heart Disease Studies
- Infrared Target Detection Methodologies
- Advanced Control and Stabilization in Aerospace Systems
- Medical Imaging Techniques and Applications
- Radio Wave Propagation Studies
- Metabolism, Diabetes, and Cancer
- Quality and Management Systems
- Acute Myocardial Infarction Research
- Medical Device Sterilization and Disinfection
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Guidance and Control Systems
- Health Systems, Economic Evaluations, Quality of Life
- Birth, Development, and Health
- Cardiac pacing and defibrillation studies
- Angiogenesis and VEGF in Cancer
- Cardiac Valve Diseases and Treatments
- Advanced Measurement and Detection Methods
- Radiopharmaceutical Chemistry and Applications
- Target Tracking and Data Fusion in Sensor Networks
- Coronary Artery Anomalies
- Cardiovascular Disease and Adiposity
Istituto di Fisiologia Clinica
2007-2024
National Research Council
2010-2024
National Research Council
2024
National Academies of Sciences, Engineering, and Medicine
2010-2014
Czech Academy of Sciences, Institute of Physiology
2014
Although the angiogenic effect of vascular endothelial growth factor (VEGF) is widely recognized, a central question concerns whether vessels formed on its overexpression effectively increase tissue perfusion in vivo. To explore this issue, here we exploit AAV vectors to obtain prolonged expression VEGF and angiopoietin-1 (Ang1) rat skeletal muscle. Over period 6 months, muscle blood flow (MBF) permeability were measured by positron emission tomography single-photon computed tomography,...
AimsPre-treating placenta-derived human mesenchymal stem cells (FMhMSCs) with a hyaluronan mixed ester of butyric and retinoic acid (HBR) potentiates their reparative capacity in rodent hearts. Our aim was to test FMhMSCs large-animal model by employing novel combination vivo ex analyses.
Multislice CT provides information on coronary luminal narrowing and the structural abnormalities of arterial wall using densitometric analysis. We sought to investigate effects narrowing, wall, cardiovascular risk factors regional global myocardial blood flow (MBF) reserve. <b>Methods:</b> studied 68 patients (mean age ± SD, 61 10 y; 41 men, 27 women) with an intermediate probability artery disease. measured severity stenoses fibroadipose, fibromuscular, calcium components by 64-row...
A track-while scan (TWS) algorithm is developed for targets in a clutter environment. The problem has been studied using only the position measurements [1, 5-8], but simulation results have not satisfactory. Modern processing techniques (FFT processor) ) air traffic control and surveillance radar receivers provide both radial velocity. velocity measurement may be conveniently used target-track correlation process, which will reduce association ambiguity t. In clear environment treated [3,...
<b>Objective:</b> To assess whether chronic treatment with carvedilol can increase myocardial blood flow (MBF) and MBF reserve in idiopathic dilated cardiomyopathy (IDC). <b>Study design:</b> In a double-blind, placebo-controlled trial, 16 consecutive patients IDC were randomised to either up 25 mg twice day (n = 8, 7 men, mean (SD) age 60 (9) years, left ventricular ejection fraction (LVEF) 30% (5%)), or placebo 6 62 LVEF 28% (6%), NS vs group). Before months after treatment, regional was...
Brain glucose exposure may complicate diabetes and obesity. We used positron emission tomography with (18)F-fluorodeoxyglucose in Zucker obese, diabetic, control rats to determine the contributions of blood mass action versus local mechanisms regulating central disposal fasted acutely glucose-stimulated states, their adaptations obesity diabetes. Our study data indicate that brain uptake is dependent on both components, stimulated by acute intake healthy rats. In diseased animals, organ was...
Multiradar tracking using both position and radial velocity measurements is discussed. The measurement of two or more different components allows the calculation rectangular components. noise filtered a Kalman filter in same way as Cartesian Before conversion from to coordinates, velocities are aligned on time scale account for shift radar measurements. In order compare multiradar system performance with without velocity, some simulation tests have been performed typical paths. results show...
The application of data-filtering techniques for air-traffic-control and surveillance systems is re-reviewed. Operational requirements these are primarily described. They typically composed radars (mechanical scanning phased array), data-processing devices (digital computers) displays. environment determined by the number characteristics targets density unintentional (weather, etc.) intentional interferences. effect on filtering used also considered. In case air traffic control, a(?, s)...
A quality management system is an important tool for improving organisation's performance. It widely applied in private companies, but rarely used the field of scientific research by public bodies. The aim this study to describe how ISO 9001:2008 can improve performance a institute introducing 4A's strategy: Audit, Awareness, Assessment, and Accountability. Data collected before 2007 are compared those obtained period between 2008 2012, data analysis shows general improvement all Institute...
In this paper we report some preliminary results obtained through an analytical and simulation approach relevant to a Surveillance Secondary Radar (SSR) monopulse extractor be devised in discrete address system for Air Traffic Control (ATC). This research concerns national special project ATC financed by the Italian National Research Council, which is also develop new secondary radar systems.
Background and aims. Enhanced release of triglycerides (TG) by the liver is implicated in pathogenesis metabolic syndrome. The aim study was to evaluate whether a primary elevation hepatic glucose utilization (HGU), as induced an acute rise circulating values during physiological hyperinsulinemia, promotes TG synthesis spite reduction free fatty acids (FFA) levels. Methods. Glucose dose–response studies were conducted anesthetized pigs using positron emission tomography (PET) quantify HGU...
Cardiovascular and metabolic vulnerability have an early developmental origin. We evaluated the potential influence of innate life factors, including metabolism mother sex offspring, on cardiometabolic risk, organ-specific insulin resistance, subclinical cardiac dysfunction, DNA oxidative damage throughout lifespan.Two female minipigs were studied during late pregnancy, their offspring restudied at ages 1 mo (n = 11), 6 9), 9 10, 4 age-matched animals). measured insulin-mediated glucose...
Risk assessment and management during the entire production process of a radiopharmaceutical are pivotal factors in ensuring drug safety quality. A methodology quality risk has been performed by integrating advice reported Eudralex, ICHQ, ISO 9001, its validity evaluated applying it to real data collected 21 months activities 18F-FDG at Officina Farmaceutica, CNR-Pisa (Italy) confirm whether critical aspects that previously have identified were effective. The analysis results matched...
Cardiometabolic risk factors, including high fasting plasma glucose (hFPG), are emerging prognostic determinants in patients with coronary artery disease (CAD) or heart failure (HF). Coronary microvascular dysfunction might be a comprehensive predictor these patients. The purpose of this study was to assess whether hFPG and global myocardial blood flow (MBF) reserve measured by positron emission tomography (PET), expressing function, predict long-term prognosis beyond other factors presence...
Abstract Background Cardiometabolic risk factors, including high fasting plasma glucose (hFPG), are emerging determinants of residual mortality in patients with coronary artery disease (CAD) or heart failure (HF). Coronary microvascular dysfunction, encompassing a broad spectrum traditional and might be comprehensive predictor these patients. Purpose To assess whether hFPG global myocardial blood flow (MBF) reserve measured by positron emission tomography (PET), expressing function, may...
In recent years the contraction of public and private investments in many countries has had a negative impact on research activities innovation.The strategic fundraising become increasingly complicated need for accountability to stakeholder spending funding drawn requires full transparency effective organization management.The institutions be more competitive transparent could optimize its management introducing new organizational models such as Performance Management System.The adoption...