A5008782167- Sulfur Compounds in Biology
- Eicosanoids and Hypertension Pharmacology
- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Cardiac electrophysiology and arrhythmias
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- Genomics, phytochemicals, and oxidative stress
- Mast cells and histamine
- Phytochemicals and Antioxidant Activities
- Phenothiazines and Benzothiazines Synthesis and Activities
- Computational Drug Discovery Methods
- Receptor Mechanisms and Signaling
- Synthesis and biological activity
- Inflammatory mediators and NSAID effects
- Synthesis and Characterization of Heterocyclic Compounds
- Asthma and respiratory diseases
- Adenosine and Purinergic Signaling
- Garlic and Onion Studies
- Sirtuins and Resveratrol in Medicine
- Antioxidant Activity and Oxidative Stress
- Synthesis and Reactions of Organic Compounds
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
University of Pisa
2016-2025
East China Normal University
2024
KU Leuven
2022
Stanford University
2018
University of Parma
2013
Istituto Superiore di Sanità
2009
University of Florence
2009
University of Perugia
2003-2008
University of Naples Federico II
2005
A small library of arylthioamides 1-12 was easily synthesized, and their H2S-releasing properties were evaluated both in the absence or presence an organic thiol such as l-cysteine. number (1-3 7) showed a slow l-cysteine-dependent mechanism, similar to that exhibited by reference agents, diallyl disulfide (DADS) phosphinodithioate derivative GYY 4137. Compound 1 strongly abolished noradrenaline-induced vasoconstriction isolated rat aortic rings hyperpolarized membranes human vascular smooth...
Hydrogen sulfide is an endogenous pleiotropic gasotransmitter, which mediates important physiological effects in the human body. Accordingly, impaired production of hydrogen contributes to pathogenesis disorders. To date, exogenous compounds, acting as sulfide-releasing agents, are viewed promising pharmacotherapeutic agents. In a recent report, properties some synthetic aryl isothiocyanate derivatives have been reported, indicating that function can be suitable slow moiety, endowed with...
Therapeutic use of sulfhydrylated inhibitor S-zofenopril has raised different hypotheses regarding the role played by its thiol group in beneficial clinical effects exerted compared with other angiotensin-converting enzyme (ACE) inhibitors. Here, we investigated hydrogen sulfide (H2S) pathway as accountable for extra-beneficial vascular function. Spontaneously hypertensive rat (SHRs) and control Wistar Kyoto (WKY) rats were treated either or enalapril vivo. Aorta carotid harvested ex vivo...
Sirtuin 1 (SIRT1) enzyme plays a pivotal role in the regulation of many physiological functions. In particular, it is implicated ageing-related diseases, such as cardiac hypertrophy, myocardial infarct, and endothelial dysfunction; moreover, its expression decreases with age. Therefore, an effective strategy to extend lifespan improve cardiovascular function enhancement expression/activity SIRT1 exogenous agents. The Citrus flavonoid naringenin (NAR) presents structural similarity natural...
The healthy properties of pomegranate fruit, a highly consumed food, have been known for long time. However, the supply chain is still rather inefficient, with non-edible fraction, whose weight roughly half total and endowed plenty valuable bioactive compounds, either disposed or underutilized. A novel extract obtained from byproducts (called PPE), using hydrodynamic cavitation, green, efficient, scalable technique, was investigated its cardiovascular effects in vivo. PPE showed efficacy an...
Background and purpose. The aim of this study was to investigate, in vascular smooth muscle cells, the mechanical electrophysiological effects (+/−)‐naringenin. Experimental approach. Aorta ring preparations single tail artery myocytes were employed for functional patch‐clamp experiments, respectively. Key results. (+/−)‐Naringenin induced concentration‐dependent relaxation endothelium‐denuded rat aortic rings pre‐contracted with either 20 mM KCl or noradrenaline (pIC 50 values 4.74 4.68,...
Abstract Objective Flavonoids are important components of ‘functional foods’, with beneficial effects on the cardiovascular function, mainly due to their antioxidant activity. Many flavonoids exert antihypertensive, anti-atherosclerotic and antiplatelet activity positive against endothelial dysfunction. Recent evidence indicates that they cardioprotective myocardial ischaemia/reperfusion (I/R) injury. The aim this work was investigate these properties for different structural...
AimsPlasmalemmal Kv7.1 (KCNQ1) channels are critical players in cardiac excitability; however, little is known on the functional role of additional Kv7 family members (Kv7.2-5) cells. In this work, expression, function, cellular and subcellular localization, potential cardioprotective against anoxic-ischaemic injury Kv7.4 have been investigated.