A5031764988- Enzyme Structure and Function
- Amino Acid Enzymes and Metabolism
- Biochemical effects in animals
- Drug Solubulity and Delivery Systems
- Antibiotic Resistance in Bacteria
- Advanced Drug Delivery Systems
- Plant tissue culture and regeneration
- Enzyme Production and Characterization
- Respiratory viral infections research
- Polyamine Metabolism and Applications
- Peptidase Inhibition and Analysis
- Plant Virus Research Studies
- Vibrio bacteria research studies
- Biochemical and Structural Characterization
- Yersinia bacterium, plague, ectoparasites research
- Infectious Diseases and Tuberculosis
- Microbial Natural Products and Biosynthesis
- CRISPR and Genetic Engineering
- Phytoplasmas and Hemiptera pathogens
- Plant-derived Lignans Synthesis and Bioactivity
- Bacterial Genetics and Biotechnology
- Aquaculture Nutrition and Growth
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Heat shock proteins research
Valley Medical Center
2025
Industrial University of Ho Chi Minh City
2016-2024
Vietnam National University, Hanoi
2023-2024
Vietnam Academy of Science and Technology
2022-2023
Vinmec International Hospital
2023
Viet Duc Hospital
2021
Czech Academy of Sciences, Institute of Biotechnology
2020-2021
Konkuk University
2012-2019
VNU University of Science
2017
Vrije Universiteit Brussel
2010-2013
Chemical pesticides remain the predominant method for pest management in numerous countries. Given current landscape of agriculture, development biopesticides has become increasingly crucial. The strategy empowers farmers to efficiently manage pests and diseases, while prioritizing minimal adverse effects on environment human health, hence fostering sustainable management. In recent years, there been a growing interest optimism surrounding utilization peptide crop protection. These...
Hairy root induction system has been applied in various plant species as an effective method to study gene expression and function due its fast-growing high genetic stability. Recently, these systems have shown be tool evaluate activities of CRISPR/Cas9 for genome editing. In this study, Rhizobium rhizogenes mediated hairy was optimized provide validation transformation vector, construct well selection targeted gRNAs editing cucumber ( Cucumis sativus L.). Under the conditions including OD...
Abstract During a 2023 outbreak of Mycoplasma pneumoniae–associated community-acquired pneumonia among children in northern Vietnam, we analyzed M. pneumoniae isolated from nasopharyngeal samples. In almost half (6 13) samples tested, found known A2063G mutations (macrolide resistance) and novel C2353T variant on the 23S rRNA gene.
This case report presents the of a 41-year-old Caucasian male with no significant past medical history who presented to emergency department (ED) due altered mental status. The patient used his brother's inhaler shortness breath (SOB) and wheezing without any improvement. Later was brought ED via Emergency Medical Services (EMS) intubated severe respiratory acidosis. Although showed some features pulmonary embolism (PE) on arrival ED, PE not first differential diagnosis. underscores...
During HIV infection and/or antiretroviral therapy (ART), monocytes and macrophages exhibit a wide range of dysfunctions which contribute significantly to pathogenesis therapy-associated complications. Nevertheless, the molecular components these remain elusive. We therefore applied parallel approach genome-wide microarray analysis focused gene expression profiling on from patients in different stages ART further characterise dysfunctions. Processes involved apoptosis, cell cycle, lipid...
Objective: Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a common complication in HIV-TB co-infected patients receiving combined antiretroviral therapy (cART). This study investigated putative contribution of monocytes to the development TB-IRIS. Design: A prospective was designed compare gene expression between who developed TB-IRIS with matched non-TB-IRIS controls. Methods: We performed hypothesis-generating transcriptome analysis on patients. Identified...
We are reporting a short and convenient pathway for the synthesis of novel β‐carboline‐bisindole hybrid compounds from relatively cheap commercially available chemicals such as tryptamine, dialdehydes indoles. These newly designed can also be prepared in high yields with tolerance many functional groups under mild conditions. Notably, these exhibited some promising applications anticancer agents against three common cancer cell lines MCF‐7 (breast cancer), SK‐LU‐1 (lung HepG2 (liver cancer)....
Xanthomonas oryzae pv. (Xoo) causes bacterial blight on rice; this species is one of the most destructive pathogenic bacteria in rice cultivation worldwide. Peptide deformylase (PDF) catalyzes removal N-formyl group from N-terminus newly synthesized polypeptides cells and an important target to develop antibacterial agents. We determined crystal structures Xoo PDF (XoPDF) at up 1.9 Å resolution, which include apo, two substrate-bound (methionine-alanine or methionine-alanine-serine),...
Under the pressure of Human Adenovirus (HAdV)-associated acute respiratory infection (ARI) outbreak in children Northern Vietnam end 2022, this study was initiated to identify HAdV subtype(s) and examine associated clinical features risk factors more severe cases.This evaluated pediatric patients with ARI which had tested positive for between October November 2022 using a multiplex real-time PCR panel. Nasopharyngeal aspirates or nasal swab samples were used sequencing subtypes. Clinical...
Endophytic fungi are promising sources for the production of podophyllotoxin-an important anticancer compound, replacing depleted medical plants. In this study, endophytes associated with Dysosma difformis-an ethnomedicinal plant species were isolated to explore novel podophyllotoxin. Fifty-three endophytic and identified by morphological observation ITS-based rDNA sequencing, assigning them 27 genera in 3 divisions. Fusarium was found most prevalent genus a colonization frequency 11.11%,...
Microbial fuel cells are a recently emerging technology that promises number of applications in energy recovery, environmental treatment and monitoring. In this study, we investigated the effect inoculating sources on enrichment electrochemically active bacterial consortia sensor-typed microbial (MFCs). Several MFCs were constructed, operated with modified artificial wastewater inoculated different from natural soil, mud, activated sludge, mixture those sources. After enrichment, soil source...
Fructose 1,6-bisphosphate aldolase (FBA) is important for both glycolysis and gluconeogenesis in life. Class II (zinc dependent) FBA an attractive target the development of antibiotics against protozoa, bacteria, fungi, also widely used to produce various high-value stereoisomers chemical pharmaceutical industry. In this study, crystal structures class Escherichia coli (EcFBA) were determined from four different crystals, with resolutions between <TEX>$1.8{\AA}$</TEX> <TEX>$2.0{\AA}$</TEX>....
D-Alanyl-D-alanine is an essential precursor of bacterial peptidoglycan and synthesized by D-alanine-D-alanine ligase (DDL) with hydrolysis ATP; this reaction makes DDL important drug target for the development antibacterial agents. Five crystal structures from Yersinia pestis (YpDDL) were determined at 1.7–2.5 Å resolution: apo, AMP-bound, ADP-bound, adenosine 5′-(β,γ-imido)triphosphate-bound, D-alanyl-D-alanine- ADP-bound structures. YpDDL consists three domains, in which four loops, loop...
Along with the co-chaperonin GroES, chaperonin GroEL plays an essential role in enhancing protein folding or refolding and protecting proteins against misfolding aggregation cellular environment. The XoGroEL gene (XOO_4288) from Xanthomonas oryzae pv. was cloned expressed, purified crystallized. crystallized using hanging-drop vapour-diffusion method a crystal diffracted to resolution of 3.4 Å. belonged orthorhombic space group P212121 14 monomers asymmetric unit, corresponding VM 2.7 Å(3)...