A5014493357- Traditional and Medicinal Uses of Annonaceae
- Phytochemical compounds biological activities
- Alkaloids: synthesis and pharmacology
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Ginger and Zingiberaceae research
- Chemical synthesis and alkaloids
- Essential Oils and Antimicrobial Activity
- Insect Pest Control Strategies
- Bioactive Compounds and Antitumor Agents
- Natural Antidiabetic Agents Studies
- Natural Compound Pharmacology Studies
- Piperaceae Chemical and Biological Studies
- Synthesis of Organic Compounds
- Cholinesterase and Neurodegenerative Diseases
- Corrosion Behavior and Inhibition
- X-ray Diffraction in Crystallography
- Phytochemistry and Bioactivity Studies
- Crystallization and Solubility Studies
- Concrete Corrosion and Durability
- Marine Sponges and Natural Products
- Bioactive natural compounds
- Phytochemicals and Antioxidant Activities
- Cocoa and Sweet Potato Agronomy
- Synthesis and biological activity
University of Malaya
2016-2025
Department of Chemistry Malaysia
2022
University of Technology Malaysia
2020-2021
Hospital Kuala Lumpur
2020
Sanata Dharma University
2019
Indiana University
2019
Université Paris Cité
2019
Kent State University
2019
Institut de Chimie des Substances Naturelles
1991-2015
Universiti Sains Malaysia
2014
Catharanthus roseus (L.) G. Don is a herbal plant traditionally used by local populations in India, South Africa, China and Malaysia to treat diabetes. The present study reports the vitro antioxidant antidiabetic activities of major alkaloids isolated from leaves extract. Four alkaloids—vindoline I, vindolidine II, vindolicine III vindolinine IV—were identified dichloromethane extract (DE) this plant’s leaves. DE compounds I–III were not cytotoxic towards pancreatic β-TC6 cells at highest...
A methanol-soluble extract of the bark Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led identification active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in presence a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, quorum sensing-regulated pyocyanin biofilm formation Pseudomonas aeruginosa PAO1. These results suggest that...
Alkaloid extracts of leaves (OOL) and bark (OOB) Ochrosia oppositifolia, as well isoreserpiline (ISR), the major alkaloid isolated from OOL OOB, were investigated potential corrosion inhibitors for mild steel (MS) in 1 M HCl medium. The inhibition properties these phytoconstituents studied using electrochemical techniques (potentiodynamic polarization measurements impedance spectroscopy, EIS) scanning electron microscopy (SEM). results indicated that green effectively reduced rate....
Staggered and systematic arrangement of<italic>N</italic>-methyllaurotetanine<bold>2</bold>on the MS surface.
The essential oil of the bark Cinnamomum altissimum Kosterm. obtained by hydrodistillation was analyzed capillary GC and GC–MS. characterized linalool (36.0%), methyl eugenol (12.8%), limonene (8.3%), α-terpineol (7.8%) terpinen-4-ol (6.4%). content total phenolics in extracts determined spectrometrically according to Folin–Ciocalteu procedure calculated as gallic acid equivalents (GAE). A phenolic compound 50.41 ± 0.98 μg GAE/mg oil. extract displayed antioxidant activities, with an IC50...
This research aimed to determine the topical administration effect of combination
Oligostilbenoids are polyphenols that widely distributed in nature with multifaceted biological activities. To achieve biomimetic synthesis of unnatural derivatives, we subjected three resveratrol analogues to oligomerization by means one-electron oxidants. Upon varying the metal oxidant (AgOAc, CuBr(2), FeCl(3)6 H(2)O, H(2)O/NaI, PbO(2), VOF(3)), solvent (over whole range polarities), and oxygenated substitution pattern starting material, stilbenoid oligomers totally different carbon...
Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures compounds characterised by means spectroscopic techniques (UV, IR, MS, 1H- 13C-NMR, DEPT, COSY, HMQC, HMBC, MS analysis). All tested 1–4 exhibited antituberculosis activity against Mycobacterium tuberculosis H37Rv, MIC values 50 µg/mL for 1–3, 100 compound 4, whereas, methanol extract 625 µg/mL. This...
Polygonum chinense is a Malaysian ethnic plant with various healing effects. This study was to determine preventive effect of aqueous leaf extract P. against ethanol-induced gastric mucosal injury in rats. Sprague Dawley rats were divided into seven groups. The normal and ulcer control groups orally administered distilled water. reference group 20 mg/kg omeprazole. experimental received the extracts 62.5, 125, 250, 500 mg/kg, accordingly. After sixty minutes, water absolute ethanol given (5...
Curcumenol attenuates the inflammatory responses induced by LPS in BV-2 microglial cells.
Curcuma zedoaria also known as Temu putih is traditionally used in food preparations and treatment of various ailments including cancer. The cytotoxic activity hexane, dichloromethane, ethyl acetate, methanol, the methanol-soxhlet extracts rhizomes was tested on two human cancer cell lines (Ca Ski MCF-7) a noncancer line (HUVEC) using MTT assay. Investigation chemical components hexane dichloromethane fractions gave 19 compounds, namely, labda-8(17),12 diene-15,16 dial ( 1 ), dehydrocurdione...
Two new acridone alkaloids, chlorospermines A and B (1 2), were isolated from the stem bark of Glycosmis chlorosperma, together with known atalaphyllidine (3) acrifoline (4), by means bioguided isolation using an in vitro enzyme assay against DYRK1A. Acrifoline (4) to a lesser extent chlorospermine (2) showed significant inhibiting activity on DYRK1A IC50's 0.075, 5.7, 2.2 μM, respectively. Their selectivity profile was evaluated panel various kinases, molecular docking calculations provided...
Aedes aegypti, albopictus and Culex quinquefasciatus are vectors of dengue fever West Nile virus diseases. This study was conducted to determine the toxicity, mechanism action binding interaction three active phenylpropanoids from Piper sarmentosum (Piperaceae) toward late 3rd or early 4th larvae above vectors. A bioassay guided-fractionation on hexane extract roots led isolation identification phenylpropanoids; asaricin 1, isoasarone 2 trans-asarone 3. The current involved evaluation...