A5078244307- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- Tuberculosis Research and Epidemiology
- Click Chemistry and Applications
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Evaluation
- Mycobacterium research and diagnosis
- Synthesis and Characterization of Heterocyclic Compounds
- Bioactive natural compounds
- Seed and Plant Biochemistry
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and Biological Activity
- Biological and pharmacological studies of plants
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Tannin, Tannase and Anticancer Activities
- Medicinal Plant Research
- Synthesis of Organic Compounds
- Fungal Plant Pathogen Control
- Phytochemical compounds biological activities
Universiti Sains Malaysia
2012-2024
Hospital Universiti Sains Malaysia
2021
Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures compounds characterised by means spectroscopic techniques (UV, IR, MS, 1H- 13C-NMR, DEPT, COSY, HMQC, HMBC, MS analysis). All tested 1–4 exhibited antituberculosis activity against Mycobacterium tuberculosis H37Rv, MIC values 50 µg/mL for 1–3, 100 compound 4, whereas, methanol extract 625 µg/mL. This...
A series of novel 4-thiazolidinone inhibitors SKYa–SKYg, containing coumarin as a core structure were synthesized via facile and efficient method. The structures the compounds established by extensive spectroscopic studies (FT IR, 1D NMR, 2D LC–MS) elemental analysis. All hybrids further evaluated for their potential anti-tubercular agents against Mycobacterium tuberculosis H37Rv ATCC 25618, anti-bacterial Escherichia coli, Enterobacter aerogenes, Salmonella typhi, Streptococcus pneumoniae...
Costus speciosus, Cymbopogon citratus, and Tabernaemontana coronaria are herbal plants traditionally used as remedies for symptoms of tuberculosis (TB) including cough. The aims the present study were to evaluate in vitro anti-TB activity different solvent partitions these plants, identify phytochemical compounds, assess effects most active on growth kinetics cellular integrity tubercle organism.The plant materials was determined against M. H37Rv using a tetrazolium colorimetric...
Increased reports of oseltamivir (OTV)-resistant strains the influenza virus, such as H274Y mutation on its neuraminidase (NA), have created some cause for concern. Many studies been conducted in attempt to uncover mechanism OTV resistance NA. However, most reported focused only drug-bound system, so direct effects NA itself prior drug binding still remain unclear. Therefore, molecular dynamics simulations apo form, followed by principal component analysis and interaction energy...
Abstract Chalcone is an important biosynthetic precursor, due to the diverse pharmacological activities. The aim of this current study was synthesize 14 new chalcone derivatives compounds by incorporating p -alkoxyacetophenones with substituted benzaldehydes. Two series have been synthesized using alkylation and base catalysed Claisen-Schmidt condensation. All were fully characterized IR, 1D NMR ( 1 H 13 C NMR) 2D (COSY, HMQC, HMBC) as well mass spectrometry analysis. assayed in vitro for...
Ixora coccinea L. (Rubiaceae) has been used traditionally for a variety of ailments and also cultivated ornamental purposes. The present study investigated antimicrobial activity methanolic extracts various parts I. determined the chemical groups active constituents. Antimicrobial was assessed using agar disc diffusion, microdilution thin layer chromatography (TLC) bioautography assays. Methanolic leaf, flower stem displayed good activity, with inhibition zone in range 6.7 to 11.3 mm....
Abstract A new dimer of natural isoflavonoid along with some known flavonoid compounds was successfully isolated from the roots Indonesian Sesbania grandiflora plant using ethyl acetate extraction. The compound specified as naturally bi-isoflavonoid (4→6) inter-isoflavanyl linkage and four flavonoids xenognosin B, liquiritigenin, 7,2′4′-trihydroxyisoflavone, demethylvestitol, 1,1′-bi-2-naphthol antituberculosis activity studied. structure all elucidated aid 1D 2D NMR, UV spectroscopy, HRESI...
Our previous study demonstrated that the effects of isoniazid (INH) on <i>Mycobacterium tuberculosis </i>at cellular level varied according to growth phases. In this study, variations in INH action <i>M. avium</i> strain NCTC 8559 are reported. cells grown Middlebrook 7H10 agar were harvested at different stages their cycle, exposed minimum inhibitory concentration INH, stained with acid-fast staining for morphological changes and acid fastness properties, number...
The development of a sustainable product using natural resources will gain much attention nowadays. This work aimed to study the effect aqueous enzymatic extraction (AEE) different ratio enzyme cocktails HEL1 and X7 towards production Momordica charantia L. (M. charantia) seed oil identify composition seeds’ lignocellulosic biomass (extracted-free materials, EFM). M. contained omega-3 fatty acids, such as stearidonic acid, that possess hypotriglyceridemic properties. obtained was derivatized...
Natural products with antimycobacterial adjuvant potential may be utilized to address the rise of multidrug-resistant tuberculosis (TB). The antioxidant-rich oil palm (Elaeis guineensis) fruit (OPF) was investigated for activity against Mycobacterium (MTB) H37Ra using bio-guided fractionation techniques, followed by determination fractional inhibition index (FIC) first-line anti-TB drugs. In vitro screening microplate Alamar blue assay showed n-hexane and chloroform partitions OPF mesocarp...
Abstract New coumarin derivatives (V) and (VIIc) exhibit very good antibacterial antifungal activities.
A series of new 2-alkylbenzysulfanyl-5-substituted-1,3,4-oxadiazoles derivatives ( 5a-j and 6a-j ) were synthesized in four-step reaction from carboxylic acid analogues as the starting materials. The compounds characterized confirmed by FTIR, 1D- 2D- NMR HRMS analyses. tested against Mycobacterium smegmatis tuberculosis determining minimum inhibitory concentration (MIC) bactericidal (MBC) values. Among them, 5c 5d most active with lowest MIC values 50 µM 25 µM, respectively. Both also...