Alkaloid extracts of leaves (OOL) and bark (OOB) Ochrosia oppositifolia, as well isoreserpiline (ISR), the major alkaloid isolated from OOL OOB, were investigated potential corrosion inhibitors for mild steel (MS) in 1 M HCl medium. The inhibition properties these phytoconstituents studied using electrochemical techniques (potentiodynamic polarization measurements impedance spectroscopy, EIS) scanning electron microscopy (SEM). results indicated that green effectively reduced rate....

Annona muricata has been used in folk medicine for the treatment of cancer and tumors. This study evaluated chemopreventive properties an ethyl acetate extract A. leaves (EEAML) on azoxymethane-induced colonic aberrant crypt foci (ACF) rats. Moreover, cytotoxic compound EEAML (Annomuricin E) was isolated, its apoptosis-inducing effect investigated against HT-29 colon cell line using a bioassay-guided approach. experiment performed five groups rats: negative control, (250 mg/kg), (500 mg/kg)...

Gastroprotective activity of Annona muricata leaves against ethanol-induced gastric injury in rats via Hsp70/Bax involvement Soheil Zorofchian Moghadamtousi,1 Elham Rouhollahi,2 Hamed Karimian,2 Mehran Fadaeinasab,3 Mahmood Ameen Abdulla,2 Habsah Abdul Kadir1 1Biomolecular Research Group, Biochemistry Program, Institute Biological Sciences, Faculty Science, 2Department Biomedical Medicine, 3Department Chemistry, University Malaya, Kuala Lumpur, Malaysia Abstract: The popular fruit tree...

Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. Murraya koenigii is an edible herb has been traditionally used cancer as well inflammation. Here, we describe girinimbine, a carbazole alkaloid isolated from M. koenigii, induced and inhibited in vitro vivo. Induction human colon cells (HT-29) by girinimbine revealed decreased cell viability HT-29, whereas there was no cytotoxic effect on normal cells. Changes mitochondrial...

Curcuma purpurascens BI. is a medicinal plant from the Zingiberaceae family, which widely used as spice and folk medicine. The aim of present study to investigate gastroprotective activity C. rhizome hexane extract (CPRHE) against ethanol- induced gastric ulcers in rats.Acute toxicity test was carried out on 36 rats (18 males 18 females) with low dose CPRHE (1 g/kg), high (2 g/kg) vehicle (5% Tween 20). To determine effect CPRHE, juice acidity, gross histological lesions, mucus content ulcer...

Curcuma purpurascens BI. (Zingiberaceae) commonly known as 'Koneng Tinggang' and 'Temu Tis' is a Javanese medicinal plant which has been used for numerous ailments diseases in rural communities. In the present study, apoptogenic activity of dichloromethane extract rhizome (DECPR) was investigated against HT-29 human colon cancer cells. Acute toxicity study DECPR performed Sprague–Dawley rats. Compounds were analyzed by gas chromatography–mass spectrometry–time flight (GC-MS-TOF) analysis....

Background/Aims: Rauvolfia reflexa is a member of the Apocynaceae family. Plants from family have been traditionally used in treatment age-related brain disorders Methods and Results: Two new indole alkaloids, rauvolfine C (1) 3-methyl-10,11-dimethoxy-6-methoxycarbonyl-β-carboline (2), along with five known, macusine B (3), vinorine (4), undulifoline (5), isoresrpiline (6) rescinnamine (7) were isolated bark reflexa. Cholinesterase inhibitory assay molecular docking performed to get insight...

Abstract: Ferulago angulata is a medicinal plant that traditionally known for its ­anti-inflammatory and antiulcer properties. The present study was aimed to evaluate anticancer activity the possible mechanism of action using MCF-7 as an in vitro model. F. leaf extracts were prepared solvents order increasing polarity. As determined by MTT assay, leaves hexane extract (FALHE) revealed strongest cytotoxicity against cells with half maximal inhibitory concentration (IC 50 ) value 5.3±0.82...

Drug resistance presents a challenge in chemotherapy and has attracted research interest worldwide particular attention been given to natural compounds overcome this difficulty. Pulchrin A, new compound isolated from products demonstrated novel potential for development as drug. The identification of pulchrin A was conducted using several spectroscopic techniques such nuclear magnetic resonance, liquid chromatography mass spectrometer, infrared ultraviolet spectrometry. cytotoxicity effects...

Plants of the Apocynaceae family have been traditionally used in treatment age-related brain disorders. Rauvolfia reflexa, a member family, has as an antidote for poisons and to treat malaria. The dichloromethane, ethanol methanol extracts from leaves reflexa showed potential acetylcholinesterase (AChE) butyrylcholinesterase (BChE) inhibitory activities, with IC50 values 8.49 52.23 g/mL range. Further cholinesterase inhibitory-guided isolation these afforded four bioactive compounds, namely:...

Abstract The K arun R iver is the most important watershed in southwestern region of I ran. Water quality parameters were sampled from O ctober 2006 through J uly 2007 at three sites along a 4 km gradient, covering both wet and dry season. Surface water was collected different stations per site (close to banks middle river) analysed for 14 heavy metals. values 1300, 196.8 4042.9 ppm chemical oxygen demand, biochemical demand chloride, respectively, higher than standards limits. index ( WQI )...

Tanacetum polycephalum (L.) Schultz-Bip (Mokhaleseh) has been traditionally used in the treatment of headaches, migraines, hyperlipidemia and diabetes. The present study aimed to evaluate its anticancer properties possible mechanism action using MCF7 as an vitro model. T. leaves were extracted hexane, chloroform methanol solvents cytotoxicity was evaluated MTT assay. Detection early apoptotic cells investigated acridine orange/propidium iodide staining. An Annexin-V-FITC assay carried out...

Seven isoquinoline alkaloids isolated from the bark of Actinodaphne macrophylla in this study demonstrated vitro antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values 0.08 µM, 0.05 1.18 3.11 0.65 0.26 and 1.38 µM for cycleanine, 10-demethylxylopinine, reticuline, laurotetanine, bicuculine, α-hydrastine anolobine, respectively, which are comparable reference standard, chloroquine. 10-Demethylxylopinine was found to be most active these compounds.

Background: Tanacetum polycephalum L. Schultz-Bip is a member of the Asteraceae family. This study evaluated chemopreventive effect T. hexane extract (TPHE) using in vivo and vitro models. Methods Results: Five groups rats: normal control, cancer TPHE low dose, high dose positive control (tamoxifen) were used for study. Histopathological examination showed that significantly suppressed carcinogenic LA7 tumour cells. The sections from TPHE-treated rats demonstrated reduced expression Ki67...

Ferulago angulata leaf hexane extract (FALHE) was found to be a potent inducer of MCF7 cell apoptosis. The aims the present study were investigate in vivo chemopreventive effect FALHE rats, identify contributing anticancer compound and determine its potential mechanism action against cells. Thirty rats harboring LA7-induced breast tumors divided into five groups: tumor control, low-dose FALHE, high-dose treatment control (tamoxifen) normal control. Breast tissues then subjected...

One new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, structural elucidation performed via spectral methods. This paper also reports antiplasmodial activity (6). results showed that 3-6 have a potent inhibitory against growth...

Abstract: Actinodaphne sesquipedalis Hook. F. Var. Glabra (Kochummen), also known as "Medang payung" by the Malay people, belongs to Lauraceae family. In this study, methanol leaf extract of A. was investigated for their acute toxicity and gastroprotective effects reduce ulcers in rat stomachs induced ethanol. The rats were assigned one five groups: normal group (group 1), ulcer 2), control positive drug 3) two experimental groups treated with 150 mg/kg 4) 300 5) extract. sacrificed an hour...

Kelussia odoratissima Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement p21/p27 vitro and vivo Hamed Karimian,1 Aditya Arya,2 Mehran Fadaeinasab,3 Mahboubeh Razavi,1 Maryam Hajrezaei,4 Ataul Karim Khan,1 Hapipah Mohd Ali,3 Mahmood Ameen Abdulla,4 Mohamad Ibrahim Noordin1,5 1Department Pharmacy, Faculty Medicine, University Malaya, Kuala Lumpur, 2School Taylor's University, Subang Jaya, 3Centre for Natural...

One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures elucidated by 1D 2D NMR, UV, IR, MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC50 value 30.24 ± 0.75 µM. The results implied that newly induced apoptosis in cells, suggesting its possible role as agent. In vivo acute toxicity study was performed on compound to evaluate...

Abstract: This study aimed to formulate floating gastroretentive tablets containing metformin hydrochloric acid (HCl), using various grades of hydrogel such as tamarind powders and xanthan overcome short gastric residence time the conventional dosage forms. Different concentrations hydrogels were tested determine formulation that could provide a sustained release 12 h. Eleven formulations with different ratios seed powder/tamarind kernel powder (TKP):xanthan prepared. The physical parameters...

A new linderone A, namely 2-cinnamoyl-3-hydroxy-4, 5-dimethoxycyclopenta-2, 4-dienone (5), together with three known flavonoids (1-3) and one (4), were isolated from the bark of Lindera oxyphylla. Extensive spectroscopic analysis including 1D 2D-NMR spectra determined their sturctures. In addition, antioxidant activity all compounds has been using 2, 2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH), ferric reducing power (FRAP) ferrous ion chelating (FIC) methods. Compound 3 showed...