This research aimed to determine the topical administration effect of combination

Some chalcones have been designed and synthesized using Claisen-Schmidt reactions as inhibitors of the ferredoxin ferredoxin-NADP+ reductase interaction to pursue a new selective antimalaria agent. The compounds exhibited inhibition interactions between PfFd-PfFNR in range 10.94%-50%. three strongest activities were shown by (E)-1-(4-aminophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (50%), (E)-1-(4-aminophenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one (38.16%),...

This study aims to evaluate the effects of alginate extract from Sargassum ilicifolium and okra (Abelmoschus esculentus) pods on re-epithelialization rate wound area number neutrophils, macrophages, fibroblasts, fibrocytes, collagen density in streptozotocin-induced diabetic mice. was done vivo using male mice (strain BALB/C, 3 4 months old, 30 40g). The normal control group (KN) groups (induced by streptozotocin). divided into 9 groups: three (KD), treatment (KAI), alginate-okra (KAIO)....

Objective: This study aimed to evaluate the biological activity of benzylidene benzohydrazide derivatives against Cancer Stem Cells (CSCs) through in vitro cytotoxicity tests and silico analyses using molecular docking. Methods: Four hydrazone compounds, namely benzo hydrazide (L1), 2-methyl (L2), 2-nitro (L3), 2-bromobenzylidene (L4) were used for studies. The interaction between compounds EGFR protein receptor (PDB ID: 1m17) was investigated AutoDock tools 1.5.7. PASS server predicted...

In this study, we aimed to identify the chemotherapeutic potential of Bornetella nitida, a Dasycladacean that contains various phytochemicals. Phytochemical extraction was performed using gradient maceration with n-hexane, chloroform, ethyl acetate, and methanol. Additionally, toxicity tests as well antioxidant activity, cytotoxicity, phytochemical, molecular docking analyses against three main cervical cancer proteins were performed. The B. nitida extracts showed moderate LC50 ranging from...

Diabetes mellitus is a group of metabolic disorders characterized by high blood-glucose levels over prolonged period that causes complications when an open wound present. Alginate antioxidant and good absorbent exudates. Okra fruit contains flavonoids can act as antioxidants. The properties extracts combination reduce significantly to accelerate the activities wound-healing processes on diabetic mice. was Size Exclusion Chromatography-Multiple Angle Laser Light Scattering (SEC-MALLS),...

A diabetic foot ulcer is an open wound that can become sore and frequently occurs in patients. Alginate has the ability to form a hydrophilic gel when contact with surface Xanthones are main compounds of mangosteen rind have antibacterial anti-inflammatory properties. The purpose this research was evaluate healing antioxidants assay combination alginate from S. ilicifolium extracts on mice model. characterization carried out by size exclusion chromatography multiple angle laser light...

The leaves of Beilschmiedia brevipes provided a new benzylisoquinoline alkaloid: (6,7-dimethoxy-4-methylisoquinolinyl)-(4’-methoxyphenyl)-methanone (1) and O,O-dimethylannocherin A (2), natural compound which has been synthesized before. Complete 1H- 13C-NMR data both compounds were reported. structures established through various spectroscopic methods notably 1D- 2D-NMR, UV, IR HRESIMS.

Hard-shell capsules commonly consist of gelatin which is not a universal material considering it extracted from animal parts. Moreover, the mad cow disease triggered scrutinization use in pharmaceutical products. Hence, an alternative to conventional hard-shell needed. Carrageenan- (CRG-) based were successfully prepared by cross-linking CRG with maltodextrin (MD) and plasticizing sorbitol (SOR). These CRG-MD/SOR produced as oral drug delivery system (DDS). The physical properties...

Abstract The release of drugs from solid drug delivery materials has been studied intently in recent years. Quantitative analyses achieved vitro dissolution becomes easier if a zero-order mathematical model is used. Non-gelatin nutraceutical hard-shell capsules zero size (approximately 0.7-0.8 cm) were produced carrageenan-based natural polymers, namely carrageenan-alginate (CA) and carrageenan-starch (CS). Disintegration, kinetics containing 100 mg salicylamide studied. disintegration time...

Introduction: Diabetes mellitus (DM) is a chronic disease with diverse and complex metabolic disorders. DM can be identified hyperglycemic conditions. In 2017, Indonesia ranked sixth in the world for highest number of diabetic patients after China, India, United States, Brazil, Mexico. Objective: This study aims to determine combined effect alginate extract from Sargassum duplicatum ilicifolium okra (Abelmoschus esculentus) mangosteen (Garcinia mangostana) pericarp extracts ameliorate...

Ferredoxin-NADP + reductases (FNRs, EC 1.18.1.2) were found in the plastids of Plasmodium and have been considered as a target for development new antimalarial agents. Croomine, epi -croomine, tuberostemonine, javastemonine A, isoprotostemonine are isolated alkaloids from roots Stemona sp. their inhibitory effect on FNRs falciparum (Pf FNR) was investigated. Croomine showed highest level inhibition (33.9%) electron transfer Pf FNR to Fd, while tuberstemonine displayed (55.4%) diaphorase...

The development of analytical methods histamine using Ni (II) and alizarin red S reagents by UV-Vis spectrophotometry has been done. objective this research is to determine the ability Ni(II) form color complex compound with it will be used detect presence qualitatively quantitatively as well. Absorbance was measured at a maximum wavelength 604 nm. In method, carried out optimization parameters such concentration Ni(II), S, pH, respond time. Analytical parameter showed 20 ppm, 75 pH 8, time...

The majority of energy was used in this period is from fossil fuel, which getting decreased the future. objective research production and characterization sulfonated chitosan-sodium alginate found brown algae (Sargassum sp.) composite membrane as Proton Exchange Membrane Fuel Cell (PEMFC) for alternative energy. PEMFC produced with 4 variations (w/w) ratio between chitosan sodium alginate, 8 : 0, 1, 2, (w/w). mixed solution into H2SO4 0.72 N. PEM uses Modulus Young analysis, water swelling,...

Abstract Sargassum sp. is one of the brown algae species. Two species were collected from Deere coast, Alor East Nusa Tenggara (NTT), and Krokoh beach, Gunung Kidul Yogyakarta. This paper compares phytochemical screening two by using three different polarity solvents. The dried, cut, ground into powder. Their extracted successive ethanol, ethyl acetate, n-hexane. Phytochemical all extracts sp performed with spot tests as standard methods. ethanol Yogyakarta NTT showed presence saponins,...

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The prevalence of cervical cancer remains at the top rankings in world threatening millions women's lives, especially Indonesia. However, growth can be prevented presence compounds with good and antiviral activity. This study was performed silico by binding a hydrazone ligands molecule to HPV-18 (Human papillomavirus) (ID: 6ZFD) on A chain. ligand were first drawn 3D structures using Avogadro then geometric optimization frequency calculations carried out B3LYP/6-31G* Gaussian 16. Molecular...

This study investigated the butyrylcholinesterase (BChE) inhibitory activity of harmane (

A field experiment Porang (Amorphophallus mueleri Blume) has the potential to be developed as a functional food ingredient because it contains high levels of glucomannan. Research on acute toxicity test macerated porang flour been carried out. The results research showed toxic effect which was characterized by SGOT and sodium levels. purpose this study find out safety level consuming with lowered calcium oxalate content. This an experimental designed in one directional-pattern Completely...

Marine algae are increasingly becoming a potential resource for new drugs. In recent decades, including