A5018644855- Medicinal Plant Research
- Plant Genetic and Mutation Studies
- Natural Products and Applications
- Bioactive Compounds and Antitumor Agents
- Seaweed-derived Bioactive Compounds
- Marine Sponges and Natural Products
- Genetics, Bioinformatics, and Biomedical Research
- Traditional and Medicinal Uses of Annonaceae
- Pharmacology and Nanomedicine Research
- Phytochemical compounds biological activities
- GABA and Rice Research
- NF-κB Signaling Pathways
- Aquatic life and conservation
- Immune Response and Inflammation
- Plant-Derived Bioactive Compounds
- Cell death mechanisms and regulation
- Microbial Natural Products and Biosynthesis
- Curcumin's Biomedical Applications
- Food and Agricultural Sciences
- Cancer and biochemical research
- Phytochemistry and Bioactivity Studies
- Plant tissue culture and regeneration
- Fisheries and Aquaculture Studies
- Piperaceae Chemical and Biological Studies
- Synthesis and bioactivity of alkaloids
Padjadjaran University
2017-2025
National Research and Innovation Agency
2024
Universitas Garut
2019
Gunma University
2011-2017
Breast cancer is the second most common in women globally, and incidence rate has increased annually. Traditional medicine frequently used as a treatment, soursop or Annona muricata L (A. muricata) traditional medicinal plant that been widely an anticancer treatment requires more thorough study.In this research, we prepared ethanol extract three solvents, ie, ethyl acetate, n-hexane water fractions of A. leaves assessed their antiproliferation cytotoxic activity on MCF7 breast cells compared...
Introduction: Lung cancer is recognized as a highly lethal disease, demanding swift and accurate solutions. Previous analysis showed the cytotoxic impact of Callyspongia aerizusa (C. aerizusa) extract containing ergost-22-en-3-one ergost-7-en3-ol against A549 lung cells, with an IC 50 value 9.38 μg/mL. However, did not have cytotoxicity towards Het-1A esophagus epithelial cells. Several reviews also validated upregulation pro-apoptotic molecules inhibition anti-apoptotic linked to...
Breast cancer has become the most frequently diagnosed worldwide. Beta-sitosterol and its derivatives have been explored for anticancer properties. Therefore, this study aims to analyze testing procedure carried out on MCF7 MDA-MB-231 breast cells, as well MCF 10A non-cancerous epithelial cells. The compounds tested included β-sitosterol derivatives: 3β-galactose sitosterol, sitostenone, 3β-glucose poriferasta-5, 22E, 25-trien-3β-ol, 22-dehydrocholesterol. Cytotoxicity assay was conducted...
During a previous study that aimed to identify anticancer agents within primate-consumed plants, the present group identified Eugenia aquea (E. aquea) possessed potential as source of agents. The ethanol extract E. leaves exhibited strong inhibitory activity against proliferation human breast adenocarcinoma MCF-7 cell line. inhibition was determined using an MTT assay. performed isolate active compound generated aforementioned activity, and resulted in isolation...
Dendritic cell (DC) vaccines, as immunotherapy agents, can gather up and transport cancer-related antigens to T lymphocytes, activating anti-tumor effector responses. After being activated by DC, cytotoxic lymphocyte cells (CTL) will secrete the cytolytic granzyme B that effectively induce rapid apoptosis of target cells. On other hand, DC also several cytokines a large number exosomes, which together operate whole antigen-presenting entity. The efficacy vaccine’s treatment may be affected...
Curcuma zedoaria has been used as a traditional agent against malignant diseases. To elucidate detailed mechanisms producing such an activity, characterization and determination of molecular its antitumor effects was conducted. Inhibiting activities cell proliferation, invasion colony formation, expression levels corresponding molecules were investigated using human esophageal cancer TE-8 cells treated with the rhizome extract from C. zedoaria. Antitumor effect administered orally also...
In this study, Callyspongia aerizusa (CA), one of the most popular marine sponges for cancer therapy research, was investigated its phytochemical compounds and evaluated anticancer activity in various cell lines. Since lung is frequently diagnosed cancer, a solution from source good choice to address resistance agents. Elucidation underlying mechanism death elicited by CA extract human carcinoma cells A549 undertaken.The presence secondary metabolites methanol revealed gas...
Diabetes mellitus (DM) is a disease easily complicated by tuberculosis (TB) due to impaired function of the innate immune response. The successes discovery immunomodulatory compounds needs be continued introduce new insights into In previous studies, plant Etlingera rubroloba A.D. Poulsen (E.rubroloba) were demonstrated have potential as an immunomodulators. This study aims isolate and identify structure E.rubroloba fruit that could effectively improve response in individuals with DM...
In this study, we aimed to identify the chemotherapeutic potential of Bornetella nitida, a Dasycladacean that contains various phytochemicals. Phytochemical extraction was performed using gradient maceration with n-hexane, chloroform, ethyl acetate, and methanol. Additionally, toxicity tests as well antioxidant activity, cytotoxicity, phytochemical, molecular docking analyses against three main cervical cancer proteins were performed. The B. nitida extracts showed moderate LC50 ranging from...
Tumor necrosis factor α induced protein 3 (TNFAIP3) is a that by TNF-mediated NF-κB activation and has dual function in regulating NF-κB. TNFAIP3 associated with inflammatory carcinogenesis many cancer types. However, the clinical significance of expression esophageal squamous cell carcinoma (ESCC) not yet been reported. We examined 149 ESCC tissue specimens to determine immunohistochemistry. Western blot analyses were used detect TE-1, TE-8, TE-15 KYSE-70 cells Het-1A, non-cancerous line....
The leaves of Garcinia celebica strongly inhibit the proliferation MCF‑7 human breast adenocarcinoma cell lines. present study focused on investigating active anticancer and antiproliferative compound from G. assessing its mechanism action. Ethanol extracts were fractionated based their polarity using n‑hexane, ethyl acetate water. properties tested in vitro against cancer lines 3‑(4,5‑dimethylthiazolyl‑2)‑2,5‑diphenyltetrazolium bromide assay. was subsequently isolated column chromatography...
The gamma-ray irradiation has been used to increase the content in chemical compounds of Typhonium flagelliforme with anticancer activity. This study was determine new bioactive through 1H-NMR, 13C NMR spectra, and HR-TOF MS analysis isolated from Tipobio variety mutant plant were found fatty acid group which have potential as Two derivatives, 2-octenoic (1) 2-hexenoic (2) ethyl acetate extract rodent tuber (T. flagelliforme). structures identified based on spectroscopic evidence compared...
In a previous study, 2',4'‑dihydroxy‑6'‑methoxy‑3',5'‑dimethylchalcone (ChalcEA) isolated from the leaves of Eugenia aquea was reported to inhibit proliferation breast adenocarcinoma MCF7 cell line and promote apoptosis via activation poly(adenosine diphosphate‑ribose) polymerase protein. The present study aimed evaluate inhibitory effect ChalcEA on A549 lung cancer cells using 3‑(4,5‑dimethylthiazol‑2‑yl)‑5‑(3‑carboxylmethoxyphenyl)-2‑(4‑sulfophenyl)‑2H‑tetrazolium assay, examine ability...
Etlingera alba (EA) is one of the endemic plants grown in Sulawesi. We determined cytotoxic and anti-metastatic activity isolates obtained from EA rhizome extract. IC50 value for 1,7-diphenyl-6-heptene-3-one, sitostenone, sinapyl alcohol diacetate, acetate were 134.59; 170 ; 128.11; 161.96 μg/mL, respectively. The compounds also had anti-migration activity. 200-μg/mL Sitostenon exhibited lowest migration rate (3.32%). free bond energies sitostenon, acetate, diacetate -11.81; -8.25; -6.64;...
Typhonium flagelliforme is an Indonesian herbal plant used and applied traditionally to treat cancer diseases. Gamma rays have irradiated rodent tuber mutant at six doses gray in-crease the chemical compounds of anticancer activity. The effect isolated from ro-dent plants has never been studied published yet. Our study unveiled poten-tial stigmasterol as a remarkable cytotoxic agent significant contribution NMR spectroscopy, IR, Mass spectra, QTOF MS towards isolation identification this...
Abstract Superior mutant rodent tuber plant ( Typhoniumflagelliforme ) is a medicinal herb of Indonesia, which immensely useful for anticancer activity. Some studies reported that the leaves and tubers, conventionally parts plant, showed various anticancer, antimicrobial, antioxidant potential. This study aim to determine bioactive compounds superior plants through n -hexane ethyl acetate fractions using GC-MS analysis. Phytochemical characterization extracts was detected by qualitative A...
Sumber Daya Alam berupa spons khususnya kelas Demospongiae memiliki jumlah yang banyak danberpotensi dalam mengembangkan berbagai bidang terutama bioteknologi. Maka dari itu, perludilakukan budidaya agar dapat mempertahankan keseimbangan alam dan ketersediaannya.Budidaya merupakan upaya memperbanyak dengan waktuyang relatif singkat. Diantara pertimbangan untuk menentukan optimasi metode adalah kedalamanserta substrat digunakan. Spons bersimbiosis bakteri. Simbiosis tersebut dapatmenghasilkan...