A5030323135- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Fuel Cells and Related Materials
- Hepatocellular Carcinoma Treatment and Prognosis
- Pharmacogenetics and Drug Metabolism
- Electrocatalysts for Energy Conversion
- Berberine and alkaloids research
- Neuroendocrine Tumor Research Advances
- Conducting polymers and applications
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Alkaloids: synthesis and pharmacology
- Liver Disease and Transplantation
- Advancements in Solid Oxide Fuel Cells
- Liver physiology and pathology
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Membrane-based Ion Separation Techniques
- Pediatric Hepatobiliary Diseases and Treatments
- Lung Cancer Research Studies
- Gestational Diabetes Research and Management
- Cancer Cells and Metastasis
- Galectins and Cancer Biology
- Peptidase Inhibition and Analysis
- Pancreatitis Pathology and Treatment
Gunma University
2015-2024
Gunma Saiseikai Maebashi Hospital
2022-2024
Institute of Acoustics
2023-2024
Gunma University Hospital
2016-2021
National Hospital Organization Takasaki Medical Center
2021
Gunma Prefectural Institute of Public Health and Environmental Sciences
2021
Photonics Electronics Technology Research Association
2016-2017
National Kyushu Medical Center
2003-2015
Cubic (United States)
2011-2015
Hospital Universiti Sains Malaysia
2015
Epithelial-to-mesenchymal transition (EMT) is a fundamental process governing not only morphogenesis in multicellular organisms, but also cancer progression. During EMT, epithelial cadherin (E-cadherin) downregulated while neural (N-cadherin) upregulated, referred to as 'cadherin switch'. This study aimed investigate whether switch promotes progression cholangiocarcinoma (CC).CC cell lines were examined for migration, invasion, and morphological changes with typical EMT-induced model using...
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a malignancy that challenging to treat. Fibroblasts in ICC tissues have been identified as cancer-associated fibroblasts (CAFs) promote the malignant behaviour of cells. An antifibrotic drug nintedanib has reported suppress activated hepatic stellate cells liver fibrosis. Methods We investigated whether could cancer-promoting effect CAFs derived from vitro and vivo. Results promoted proliferation invasion Nintedanib suppressed...
Pancreatic cancer is a leading cause of cancer-related mortality and often has poor prognosis because its late diagnosis, aggressive local invasion, early metastasis response to chemotherapy. The chemotherapeutic agent gemcitabine effective for treating advanced pancreatic cancer, but efficacy remains less than satisfactory. It expected that further investigation cell invasion development strategies block this process should improve the disease prognosis. In study, we tested our hypothesis...
AIM:To compare cases of xanthogranulomatous cholecystitis (XGC) and advanced gallbladder cancer discuss the differential diagnoses surgical options. METHODS:From April 2000 to December 2013, 6 XGC patients received extended resections.During same period, 16 were proven have (GB) cancer, according resection.Subjects chosen for analysis in this study restricted with indistinct borders liver as it is often difficult distinguish these from those GB cancer.We compared clinical features computed...
Patients with extrahepatic cholangiocarcinoma (EHCC) have a poor prognosis; postoperative survival depends on cancer progression and therapeutic resistance. The mechanism of EHCC needs to be clarified identify ways improve disease prognosis. Stathmin1 (STMN1) is major cytosolic phosphoprotein that regulates microtubule dynamics associated malignant phenotypes chemoresistance in various cancers. Recently, STMN1 was reported interact p27, an inhibitor cyclin-dependent kinase complexes. Eighty...
The natural killer group 2 member D (NKG2D) receptor and its ligands are important mediators of immune responses to tumors. NKG2D overexpressed in several malignant tumor types; however, the prognostic value these is unclear. Here, we aimed elucidate role extrahepatic cholangiocarcinoma (EHCC). We therefore investigated expression MHC class I chain‐related proteins A B (MICA/B), unique long 16 binding protein (ULBP) 1, ULBP2/5/6 resected specimens from 82 patients with EHCC. All were highly...
Despite recent advances in cancer treatment, pancreatic is a highly malignant tumor type with dismal prognosis and it characterized by dense desmoplasia the tissue. Cancer‐associated fibroblasts (CAF) are responsible for this fibrotic stroma promote progression. We previously reported that novel natural compound conophylline (CnP) extracted from leaves of tropical plant reduced liver fibrosis suppression stellate cells. However, there have been no studies to investigate effects CnP on CAF,...
Abstract CKLF‐like MARVEL transmembrane domain–containing protein 6 (CMTM6) maintains membrane PD‐L1 expression by controlling its endosomal recycling. However, in patients with hepatocellular carcinoma (HCC), the correlation among CMTM6, B7 family ligands, and CD8‐positive cytotoxic T lymphocytes (CTLs), molecular function of CMTM6 HCC have not been established. We performed immunohistochemistry to evaluate relationships expression, clinicopathological factors, ligands CTL infiltration...
Background: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths worldwide. Stathmin 1 (STMN1) suppression was reported to reduce cellular viability and migration potential. However, no previous studies have addressed whether STMN1 overexpression associated with malignant potential in PDAC. Materials Methods: To clarify the clinical significance PDAC, expression 104 PDAC samples evaluated by immunohistochemistry. Moreover, we proliferative ability pancreatic...
Wisteria floribunda agglutinin (WFA)+ Mac-2-binding protein (M2BPGi) is a novel serum marker for liver fibrosis. Although an elevated level of M2BPGi can predict development hepatocellular carcinoma (HCC), the effect on HCC remains unclear. There are no reports about association with aggressiveness. We aimed to clarify significance in HCC.The expression and galectin-3, ligand M2BP, mRNA M2BP were evaluated surgically resected human samples. M2BPGi-regulating signals cells investigated using...
Extrahepatic cholangiocarcinoma (EHCC) is a cancer with poor prognosis, and the postoperative survival of patients depends on existence invasion metastasis. The epithelial‐to‐mesenchymal transition (EMT) an important step in EHCC Forkhead box protein C2 ( FOXC2 ) transcription factor that has been reported to induce EMT. Therefore we examined correlation between expression clinical pathological factors, analysed function FOXC2. 77 cases was investigated by immunohistochemical staining,...
Hepatocellular carcinoma (HCC) is one of the major causes tumor death; thus, identification markers related to its diagnosis and prognosis critical. Previous studies have revealed that epithelial-to-mesenchymal transition (EMT) involved in invasion metastasis, forkhead box protein C2 (FOXC2) has been shown promote cell proliferation, invasion, EMT. In present study, we examined clinicopathological significance FOXC2 EMT-related clinical HCC specimens identified factors HCC.The expression was...
Understanding the effect of lymph node metastasis (LNM) on prognosis in pancreatic neuroendocrine neoplasm is helpful for surgery and follow-up. In this study, we investigated significance LNM well-differentiated tumors (PanNETs) according to World Health Organization 2017 classification.We retrospectively collected data 95 consecutive patients with PanNET who underwent resection curative intent between January 2008 December at 6 institutions. The clinicopathological factors were compared...