A5017163749- Natural Compound Pharmacology Studies
- Phytochemistry and Biological Activities
- Synthesis of Organic Compounds
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemical compounds biological activities
- Traditional and Medicinal Uses of Annonaceae
- Carbohydrate Chemistry and Synthesis
- Polysaccharides and Plant Cell Walls
- Sirtuins and Resveratrol in Medicine
- Biological and pharmacological studies of plants
- Bioactive Compounds and Antitumor Agents
- Synthesis of Indole Derivatives
- Porphyrin and Phthalocyanine Chemistry
- Advanced Chemical Physics Studies
- Plant and Fungal Species Descriptions
- Synthesis and biological activity
- Synthesis and Biological Activity
- Hops Chemistry and Applications
- Plant Diversity and Evolution
- Plant chemical constituents analysis
- Fungal Biology and Applications
- Bioactive natural compounds
- Fern and Epiphyte Biology
- Plant Ecology and Taxonomy Studies
Vietnam National University Ho Chi Minh City
2014-2025
Ho Chi Minh City University of Science
2014-2025
Roskilde University
2011
National University of Singapore
1999-2005
Preventative medicine: The natural products guttiferone G and hyperforin (1) as well the synthetic aristoforin (2) are inhibitors of human SIRT1 SIRT2. Guttiferone 2 less toxic but stronger cell proliferation than 1. These compounds may be valuable tools for epigenetics elucidation biological role sirtuins in processes such cancer, ageing, neurodegenerative diseases, adipositas, diabetes. Supporting information this article is available on WWW under...
A new nemoralisin-type diterpenoid, nemoralisin O (1), along with ten previously identified compounds, was obtained from Aglaia lawii bark. Structural characterisation performed using various spectroscopic techniques, a focus on 1D and 2D NMR, HR-ESI-MS analysis. The absolute stereochemistry of compound 1 established by comparing its experimental ECD spectrum theoretical spectra all eight possible stereoisomers TD-DFT calculations, evaluating compatibility calculated 1H chemical shifts...
A new geranylated coumarin, (E)-4-(1-hydroxypropyl)-5,7-dihydroxy-6-(3,7-dimethyl-2,6-octadienyl)-8-(3-methyl-1-oxobutyl)coumarin (named surangin D), was isolated from the bark of Mammea siamensis collected in Vietnam, along with four known coumarins, surangins B and C, theraphins seven xanthones, 1,7-dihydroxyxanthone, 7-hydroxy-1-methoxyxanthone, 1,7-dimethoxyxanthone, 1,7-dimethoxy-6-hydroxyxanthone, 1,6,7-trihydroxyxanthone, 1,3,7-trihydroxyxanthone, 1,7-dihydroxy-3-methoxyxanthone....
Two new geranylated xanthones, 6-O-methylcowanin (4) and oliverixanthone (5), along with five known compounds, cowanin, rubraxanthone, cowaxanthone, cowanol, beta-mangostin, have been isolated from the bark of Garcinia oliveri. For comparison their biological activities, one mono- seven di-O-alkylated alpha-mangostin derivatives were synthesized alpha-mangostin. The structures all compounds assigned by spectroscopic methods (1D 2D NMR MS). Cytotoxicity selected xanthones against MCF-7 DLD-1...
Two new compounds, fuscaxanthones J (1) and K (2), together with eight known xanthones (3 - 10) were isolated from an ethyl acetate extract of the roots Garcinia fusca. Their structures determined using spectroscopic methods, mainly 1D- 2D-NMR. α-Glucosidase inhibitory activity compounds was evaluated fuscaxanthone showed most significant effect IC50 value 8.3 ± 1.8 μm (compared acarbose, = 214.5 2.3 μm).
Four new mexicanolide-type limonoids, swietemicrolides A–D (1–4), together with three known compounds (5–7) were isolated from an ethyl acetate extract of the bark Swietenia microphylla .
Die Naturstoffe Guttiferon G und Hyperforin (1) sowie das synthetische Aristoforin (2) sind Inhibitoren der menschlichen Sirtuine SIRT1 SIRT2. Zudem 2 weniger toxisch stärkere Zellproliferation als 1. Diese Verbindungen können wertvoll für die Epigenetik zur Aufklärung Rolle von Sirtuinen bei Krebs, Alterungsprozessen, neurodegenerativen Erkrankungen, Adipositas oder Diabetes sein. Supporting information for this article is available on the WWW under...
A new xanthone, calothorexanthone, together with five known compounds, garbogiol, 1,4,8-trihydroxyxanthone, δ-tocotrienol, 1,7-dihydroxyxanthone and globuxanthone, was isolated from a petroleum ether extract of the bark Calophyllum thorelii. Their structures were established on basis spectroscopic methods, mainly one- two-dimensional NMR. Antioxidant activity compounds tested using DPPH free radical scavenging assay some exhibited remarkable effects IC₅₀ 13.63-17.46 µg mL(-1).