A5077349136- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- RNA and protein synthesis mechanisms
- Natural Compound Pharmacology Studies
- Phytochemistry and Biological Activities
- Polysaccharides and Plant Cell Walls
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Bacterial Genetics and Biotechnology
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Phytochemistry and Bioactive Compounds
- PI3K/AKT/mTOR signaling in cancer
- Ginseng Biological Effects and Applications
- Chronic Myeloid Leukemia Treatments
- Advanced Biosensing Techniques and Applications
- Biological and pharmacological studies of plants
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
City of Hope
2015-2025
Vietnam National University Ho Chi Minh City
2016-2024
University of Cincinnati
2024
Chonnam National University Hospital
2023
Baylor College of Medicine
2023
Vietnam Military Medical University
2022
Vietnam Academy of Science and Technology
2022
Beckman Research Institute
2015-2019
The University of Texas Southwestern Medical Center
2019
Ho Chi Minh City University of Technology
2018
Tc24 is a Trypanosoma cruzi-derived flagellar protein that, when formulated with TLR-4 agonist adjuvant, induces balanced immune response in mice, elevating IgG2a antibody titers and IFN-γ levels. Furthermore, vaccination the recombinant can reduce parasite levels improve survival during acute infection. Although some mRNA vaccines have been proven to elicit stronger than vaccines, they not used against T. cruzi. This work evaluates immunogenicity of heterologous prime/boost regimen using...
Polybrominated diphenyl ethers (PBDEs) have been used as flame retardants in household materials. Their environmental persistence has led to continuous human exposure and significant tissue levels. Three PBDE congeners (BDE-47, BDE-100, BDE-153) frequently detected serum. Although these compounds appear possess endocrine disrupting activity, studies are largely missing determine the biological mechanisms of PBDEs breast cancer cells. Here, we assessed bioactivities with three complementary...
// Elizabeth T. Chang 1 , Palak R. Parekh Qingyuan Yang Duc M. Nguyen France Carrier Marlene and Stewart Greenebaum Cancer Center, School of Medicine, Department Radiation Oncology, University Maryland, Baltimore, MD, USA Correspondence to: Carrier, e-mail: fcarrier@som.umaryland.edu Keywords: cancer, hnRNP A18, hypoxia, protein translation, RNA-binding Received: August 02, 2015 Accepted: January 13, 2016 Published: 25, ABSTRACT The heterogenous ribonucleoprotein A18 (hnRNP A18) promotes...
// Brandon R. Beagle 1 , Duc M. Nguyen Sharmila Mallya Sarah S. Tang Mengrou Lu Zhihong Zeng 2,3 Marina Konopleva Thanh-Trang Vo and David A. Fruman Department of Molecular Biology & Biochemistry, University California, Irvine, CA 2 Leukemia, Texas MD Anderson Cancer Center, Houston, TX 3 Stem Cell Transplantation Cellular Therapy, Correspondence: Fruman, email: Keywords : B-ALL, mTOR, histone deacetylase inhibitor Received November 17, 2014 Accepted December 11, Published 12, Abstract High...
Abstract Although expressing adequate levels of functional tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) receptors DR4/DR5, significant proportion cancer cells exhibit resistance to the cytotoxic effect this ligand. Exposure Apo2L/TRAIL-refractory chemotherapeutic agents enhances their sensitivity Apo2L/TRAIL cytotoxicity. This study aims elucidate molecular mechanism responsible for cisplatin-mediated enhancement in cultured esophageal cells. sublethal concentrations...
Purpose: Therapeutic strategies against hormonal receptor-positive (HR+)/HER2+ breast cancers with poor response to trastuzumab need be optimized.Experimental Design: Two HR+/HER2+ patient-derived xenograft (PDX) models named as COH-SC1 and COH-SC31 were established explore targeted therapies for HER2+ cancers. RNA sequencing RPPA (reverse phase protein array) analyses conducted decipher molecular features of the two PDXs define therapeutic strategy interest, validated by in vivo drug...
Whole-abdominal radiotherapy (WART) is a primary method for managing gastrointestinal cancers that have disseminated into intra-abdominal tissues. While effective, this approach limited because of the increased toxicity to normal tissue associated with combined WART and full-dose chemotherapy regimens. Recent studies demonstrated survival advantage in novel treatment paradigm allows safe use systemic combination low-dose fractionated (LDFRT). Traditionally, radiation doses greater than 120...
Glucocorticoids are a class of hormones that include naturally occurring cortisol and corticosterone, as well prescription drugs commonly used to manage inflammatory, autoimmune, allergic conditions. Adverse effects, including neuropsychiatric symptoms, common. The hippocampus appears be especially sensitive the effects glucocorticoids. However, our knowledge, no studies date have examined hippocampal subfields in humans receiving We patients on chronic glucocorticoid regimens determine...
A new xanthone, calothorexanthone, together with five known compounds, garbogiol, 1,4,8-trihydroxyxanthone, δ-tocotrienol, 1,7-dihydroxyxanthone and globuxanthone, was isolated from a petroleum ether extract of the bark Calophyllum thorelii. Their structures were established on basis spectroscopic methods, mainly one- two-dimensional NMR. Antioxidant activity compounds tested using DPPH free radical scavenging assay some exhibited remarkable effects IC₅₀ 13.63-17.46 µg mL(-1).
Abstract Elevated activity of mTOR is associated with poor prognosis and higher incidence relapse in B-cell acute lymphoblastic leukemia (B-ALL). Thus, ongoing clinical trials are testing inhibitors combination chemotherapy B-ALL. However, the standard care drugs has not been studied extensively high-risk B-ALL subtypes. Therefore, we tested whether inhibition can augment efficacy current agents Ph+ Ph-like models. Surprisingly, inhibiting complex 1 (mTORC1) protected cells from killing by...
While ER has multiple biological effects, ER-cyclin D1-CDK4/6-RB is a critical pathway for the action of estrogen on cell cycle, especially breast cancers that rely growth. The latest and most efficient CDK4/6 inhibitors target phosphorylation retinoblastoma (RB) tumor suppressor gene; thus, altering levels many cycle molecules. Estrogen receptor (ER)+/HER2- have shown great progression free survival when are combined with endocrine therapies. Here we report mechanism antiestrogen...