A5048801644- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Functional Brain Connectivity Studies
- Satellite Image Processing and Photogrammetry
- Robotics and Sensor-Based Localization
- Nuclear Physics and Applications
- Ideological and Political Education
- Advanced Neuroimaging Techniques and Applications
- Digital Radiography and Breast Imaging
- Medical Imaging and Pathology Studies
- Calibration and Measurement Techniques
- Insurance and Financial Risk Management
- Cardiac Imaging and Diagnostics
- Advanced Vision and Imaging
- Infrared Target Detection Methodologies
- Industrial Vision Systems and Defect Detection
- 3D Surveying and Cultural Heritage
- Chinese history and philosophy
- Remote Sensing and Land Use
Janssen (Belgium)
2025
Shenzhen Institutes of Advanced Technology
2020-2024
Chinese Academy of Sciences
2011-2024
Changchun Institute of Optics, Fine Mechanics and Physics
2024
Gannan Medical University
2024
Northeastern University
2024
Yantaishan Hospital
2024
Liaoning Cancer Hospital & Institute
2024
University Town of Shenzhen
2023
Wenzhou Polytechnic
2023
Distinct physiological states arise from complex interactions among the various organs present in human body. PET is a non-invasive modality with numerous successful applications oncology, neurology, and cardiology. However, while imaging has been applied extensively detecting focal lesions or diseases, its potential systemic abnormalities seldom explored, mostly because total-body was not possible until recently.In this context, study proposes framework capable of constructing an individual...
This study examines the geographical spillover of state-level average homeowners insurance cost for 48 US contiguous states. We estimate a panel spatial Durbin model with state and year fixed effect data between 2001 2018. found significant positive as indicated by large autoregressive coefficient in baseline model. also relationship underwriters’ loss portfolio similarity cost. conduct several robustness tests show that results are robust if against potential biases due to heterogenous...
The total-body positron emission tomography (PET) scanner provides an unprecedented opportunity to scan the whole body simultaneously, thanks its long axial field of view and ultrahigh temporal resolution. To fully utilize this potential in clinical settings, a dynamic would be necessary obtain desired kinetic information from data. However, acquisition, patient movement can degrade image quality quantification accuracy.In work, we demonstrated motion correction framework importance FDG PET...
Abstract Objectives Commercialized total-body PET scanners can provide high-quality images due to its ultra-high sensitivity. We compared the dynamic, regular static, and delayed 18F-fluorodeoxyglucose (FDG) scans detect lesions in oncologic patients on a PET/CT scanner. Materials & methods In all, 45 were scanned continuously for first 60 min, followed by acquisition. FDG metabolic rate was calculated from dynamic data using full compartmental modeling, whereas static SUV obtained...
Abstract Total‐body positron emission tomography (TB‐PET) has ultra‐high sensitivity and the unique ability to conduct dynamic imaging of entire body. Both hardware configuration data acquired from a TB‐PET scanner differ those conventional short axial field‐of‐view scanners. Therefore, various aspects concerning processing need careful consideration when implementing in clinical settings. Additionally, advances analysis are needed fully uncover potential these systems. Although some...
Background/Objectives: Tumor growth dynamic modeling has been widely used to predict late outcomes and support decision-making in solid tumors [1]. In hematology area, resent research shows that M-protein may serve as a surrogate biomarker linked progression-free survival (PFS) for patients with RRMM [2]. This work aims establish model platform linking PFS across multiple drugs, treatment regiments studies, then assess the predictive value of an independent clinical trial.Methods: A total...
Although current computed tomography (CT) systems can scan the head in a very short time, patient motion sometimes still induces artifacts. If occurs, one has to repeat scan; avoid motion, sedation or anesthesia is applied.The authors propose method iteratively estimate and compensate this during reconstruction. In every iteration, rigid was estimated view-by-view then used update system matrix. A multiresolution scheme speed up convergence of joint estimation image subject. final iterative...
Statistical iterative reconstruction algorithms have shown potential to improve cone-beam CT (CBCT) image quality. Most utilize prior knowledge as a penalty term in the objective function. The greatly affects performance of algorithm. total variation (TV) has demonstrated great ability suppressing noise and improving However, calculated from first-order derivatives, TV leads well-known staircase effect, which sometimes makes reconstructed images oversharpen unnatural. In this study, we...
This study explored the feasibility of reducing scan time Patlak parametric imaging on uEXPLORER.A total 65 patients (27 females and 38 males, age 56.1 ± 10.4) were recruited in this study. 18F fluorodeoxyglucose was injected, its dose adjusted by body weight (4.07 MBq/kg). Total-body dynamic scanning performed uEXPLORER total-body Positron emission tomography/computed tomography (CT) scanner with a 60 min from injection. The image derived input function (IDIF) obtained aortic arch....
The main focus of this work is to compare different timing measurement methods individual silicon photomultiplier (SiPM) arrays and dual-ended readout PET detectors. Two lutetium yttrium oxyorthosilicate (LYSO) crystal with 3.10×3.10×20 mm3 crystals, enhanced specular reflector (ESR), barium sulfate (BaSO4) one LYSO array 1.88×1.88×20 crystals BaSO4 read out by 8×8 SiPM 3×3 mm2 active pixel area were measured. Signals the processed individually using 64 channel PETsys TOFPET2 ASICs designed...
PET image reconstruction is challenging due to the ill-poseness of inverse problem and limited number detected photons. Recently deep neural networks have been widely applied medical imaging denoising applications. In this work, based on MAPEM algorithm, we propose a novel unrolled network framework for 3D reconstruction. framework, convolutional combined with update steps so that data consistency can be enforced. Both simulation clinical datasets were used evaluate effectiveness proposed...
Efforts have been made both to avoid invasive blood sampling and shorten the scan duration for dynamic positron emission tomography (PET) imaging. A total-body scanner, such as uEXPLORER PET/CT, can relieve these challenges through following features: First, whole-body coverage allows noninvasive input function from aortic arteries; second, with a dramatic increase in sensitivity, image quality still be maintained at high level even shorter than usual. We implemented dual-time-window (DTW) protocol
Full quantification of brain PET requires the blood input function (IF), which is traditionally achieved through an invasive and time-consuming arterial catheter procedure, making it unfeasible for clinical routine. This study presents a deep learning based method to estimate (DLIF) dynamic FDG scan. A long short-term memory combined with fully connected network was used. The dataset training generated from 85 total-body scans obtained on uEXPLORER scanner. Time-activity curves 8 regions...
Previously, we proposed using an interpolated average CT (IACT) method for attenuation correction (AC) in positron emission tomography (PET), which is a good, low-dose approximation of cine (CACT) to reduce misalignments and improve quantification PET/CT. This study aims evaluate the performance IACT different motion amplitudes. We used digital four-dimensional (4-D) extended cardiac-torso phantom (XCAT) simulate maximum 2, 3, 4 cm respiratory motions. The cycle was divided into 13 phases,...
Small animal positron emission tomography (PET) scanners are widely used in current biomedical research. The study aimed to develop high-efficiency and ultra-high-resolution detectors that could be a small PET scanner with high sensitivity spatial resolution approaching its physical limit.Four crystal arrays were fabricated measured this study. Crystal 1 2 consisted of 38 × gadolinium aluminum gallium garnet (GAGG) lutetium-yttrium oxyorthosilicate (LYSO) crystals 0.4 20 mm3 size. array 3 16...
Abstract Surface defects on steel, arising from factors like steel composition and manufacturing techniques, pose significant challenges to industrial production. Efficient precise detection of these is crucial for enhancing production efficiency product quality. In accordance with requisites, this paper elects undertake the task predicated you only look once (YOLO) algorithm. study, we propose a novel approach surface flaw identification based YOLOv5 algorithm, called YOLOv5-KBS. This...
Abstract Background Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) stand as pivotal diagnostic tools for brain disorders, offering the potential mutually enriching disease perspectives. However, costs associated with PET scans inherent radioactivity have limited widespread application of PET. Furthermore, it is noteworthy to highlight promising high‐field ultra‐high‐field neuroimaging in cognitive neuroscience research clinical practice. With enhancement MRI...
The advent of positron emission tomography/computed tomography (PET/CT) provides fusion both anatomical and functional information. CT-based attenuation correction replaced (68)Ge-based for shortening acquisition time, improving image quality quantitative accuracy. However, due to the temporal difference PET CT, mis-registration motion artifacts are observed in attenuation-corrected images mainly respiratory motion. Reducing spatial mismatch CT reconstructed remains a challenge. This review...
Purpose: The temporal mismatch between PET and standard helical CT (HCT) causes substantial respiratory artifacts in reconstructed images when using HCT as the attenuation map. Previously we developed an interpolated average (IACT) method for correction (AC) demonstrated its merits simulations. In this study aim to apply IACT patients with thoracic lesions active breathing controller (ABC). Methods: Under local ethics approval, recruited 15 a total of 18 different regions: left upper lobe...
Motion of the myocardium deteriorates quality and quantitative accuracy cardiac PET images. We present a method for MR-based respiratory motion correction data evaluate its impact on estimation activity kinetic parameters in human subjects. Three healthy subjects underwent simultaneous dynamic
Both monolithic and semi-monolithic scintillator positron emission tomography (PET) detectors can measure the depth of interaction with single-ended readout. Usually scintillators a thickness 10 mm or less are used since position resolutions degrade as increases. In this work, performance 20 thick long rectangular PET detector was measured by using both dual-ended readouts silicon photomultiplier (SiPM) arrays to provide high detection efficiency. The consists nine lutetium-yttrium...
Correction for rigid object motion in helical CT can be achieved by reconstructing from a modified source-detector orbit, determined the during scan. This ensures that all projections are consistent, but it does not guarantee complete sense of being sufficient exact reconstruction. We have previously shown with phantom measurements motion-corrected scans suffer data-insufficiency, particular severe motions and at high pitch. To study whether such data-insufficiency artefacts could also...