A5039450656- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Bone health and treatments
- Orthopaedic implants and arthroplasty
- Dental materials and restorations
- Bone health and osteoporosis research
- Chemical Synthesis and Characterization
- Bone Metabolism and Diseases
- Endodontics and Root Canal Treatments
- Calcium Carbonate Crystallization and Inhibition
- Radiopharmaceutical Chemistry and Applications
- Spine and Intervertebral Disc Pathology
- Periodontal Regeneration and Treatments
- Orthopedic Infections and Treatments
- Anesthesia and Pain Management
- Bone fractures and treatments
- Bone and Dental Protein Studies
- biodegradable polymer synthesis and properties
- Spinal Fractures and Fixation Techniques
- Ferroelectric and Piezoelectric Materials
- Phosphorus and nutrient management
- Facial Trauma and Fracture Management
- Medical and Biological Sciences
- Collagen: Extraction and Characterization
- Advanced MRI Techniques and Applications
Chimie et Interdisciplinarité, Synthèse, Analyse, Modélisation
2011-2023
Nantes Université
2013-2023
Centre National de la Recherche Scientifique
2007-2023
Inserm
2005-2014
Le Laboratoire d'Ingénierie Ostéo-Articulaire et Dentaire
2005-2014
Skeleton Technologies (Estonia)
2014
Conditions Extrêmes et Matériaux Haute Température et Irradiation
2011
Atlantic University
2010
Molécules d'Intérêt Biologique
1998-2008
École Polytechnique Fédérale de Lausanne
2008
Abstract Patients with osteoporosis and joint disabilities represent a constant growing challenging population to be treated in the musculoskeletal clinical field. Especially case of total hip arthroplasty, new solutions should developed compensate for double negative factors, peri‐implant osteolysis, osteoporotic bone loss, affecting quality implant outcome. The goal this study was then establish proof concept orthopedic used as Zoledronate delivery rats, particular, verify if approach...
Compressive strength measurements were conducted on 32 macroporous biphasic calcium phosphate (MBCP) samples to evaluate the influences and interactions of five synthesis factors: chemical composition, percentage macropores, mean size isostatic compaction pressure, sintering temperature. These parameters varied simultaneously between two limit levels. Experiments used a factorial design method (FDM) allowing optimization number as well statistical analysis results. FDM showed that...
This study investigated the in vivo performance of two composite injectable bone substitutes (IBS), each with different calcium-phosphate particles granulometries [40-80 (IBS 40-80) and 200-500 microm 200-500)]. These biomaterials were obtained by associating a biphasic (BCP) ceramic mineral phase 3% aqueous solution cellulosic polymer (hydroxy-propyl-methyl-cellulose). Both materials injected for periods 2, 3, 8, or 12 weeks into defects at distal end rabbit femurs. Quantitative results on...
Calcium-phosphate ceramics used in surgery, as bone-bonding materials, are currently available different forms (blocks, granules, etc.). However, progress noninvasive surgery has favored the development of injectable composite materials associating a polymeric and dusty mineral phase. The purpose this study was vivo evaluation biphasic calcium phosphate various grains sizes, to elucidate role granulometries ceramic degradation/resorption, bone ingrowth, inflammatory reactions. Three particle...
Studies on primary osteocytes, which compose >90-95% of bone cells, embedded throughout the mineralized matrix, are a major challenge because their difficult accessibility and very rare models available in vitro. We engineered 3D culture method human osteoblast differentiation into osteocytes. These 3D-differentiated osteocytes were compared with 2D-cultured cells microdissected cortical obtained from cryosections. Human osteoblasts seeded either within interspace calibrated biphasic calcium...
It is a clinical challenge to obtain sufficient orthopaedic implant fixation in weak osteoporotic bone.When the primary poor, micromotions occur at bone-implant interface, activating osteoclasts, which leads loosening.Bisphosphonate can be used prevent osteoclastic response, but when administered systemically its bioavailability low and time it takes for drug reach periprosthetic bone may limiting factor.Recent data has shown that delivering bisphosphonate locally from surface could an...
Hydroxyapatite (HA) contents measurements were conducted on eight biphasic calcium phosphate (BCP) samples obtained by sintering calcium-deficient apatite formed previously hydrolyzing a dicalcium dihydrate (DCPD) powder. We evaluated the influences and interactions of three synthesis factors: alkalinity, process duration, concentration water suspension in DCPD. Those parameters varied simultaneously between two limit levels. Experiments used factorial design method (FDM) allowing...
Hydroxyapatite (HA) contents measurements were conducted on eight biphasic calcium phosphate (BCP) samples obtained by sintering calcium-deficient apatite formed previously hydrolyzing a dicalcium dihydrate (DCPD) powder. We evaluated the influences and interactions of three synthesis factors: alkalinity, process duration, concentration water suspension in DCPD. Those parameters varied simultaneously between two limit levels. Experiments used factorial design method (FDM) allowing...