A5057159714- Traditional and Medicinal Uses of Annonaceae
- Alkaloids: synthesis and pharmacology
- Natural product bioactivities and synthesis
- Malaria Research and Control
- Chemical synthesis and alkaloids
- Ethnobotanical and Medicinal Plants Studies
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- African Botany and Ecology Studies
- Plant-based Medicinal Research
- Metabolomics and Mass Spectrometry Studies
- Phytochemical compounds biological activities
- Berberine and alkaloids research
- Phytochemicals and Antioxidant Activities
- Plant biochemistry and biosynthesis
- Insect Pest Control Strategies
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Natural Antidiabetic Agents Studies
- Pharmacological Effects of Natural Compounds
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Sesquiterpenes and Asteraceae Studies
- Insect Utilization and Effects
- Phytochemical Studies and Bioactivities
University of Liège
2016-2025
Directorate-General Joint Research Centre
2024
Joint Research Center
2023
Pharmac
2012-2021
Institute of Organic Chemistry
2020
Université de Yaoundé I
2020
Statistics Belgium
2020
Université de Dschang
2006-2020
University of Ngaoundéré
2020
Institut de Recherches Médicales et d’Etudes des Plantes Médicinales
2020
Abstract Objectives This review covers the compounds with antiplasmodial activity isolated from plants published 2005 to end of 2008, organized according their phytochemical classes. Details are given for substances IC50 values ≤ 11 μM. Key findings Malaria is a major parasitic disease in many tropical and subtropical regions responsible more than 1 million deaths each year Africa. The rapid spread resistance encourages search new active compounds. Nature particularly used traditional...
In Cameroon, like in other African countries, infusions of Artemisia afra and annua are widely used for the management health-related problems, including malaria. The secondary metabolite contents medicinal plants vary between different geographical regions seasons, directly influencing their effectiveness treating ailments. This study explores phytochemical diversity anti-plasmodial potential A. from distinct locations within aiming to define optimal chemical composition terms activity....
Abstract The complete 1 H‐ and 13 C‐NMR assignments of the major Cannabis constituents, Δ 9 ‐tetrahydrocannabinol, tetrahydrocannabinolic acid, 8 cannabigerol, cannabinol, cannabidiol, cannabidiolic cannflavin A B have been determined on basis one‐ two‐dimensional NMR spectra including C‐NMR, H‐COSY, HMQC HMBC. substitution carboxylic acid cannabinoid nucleus (as in acid) has a large effect chemical shift H‐1″ C5 side chain 2′‐OH. It was also observed that reduces intermolecular hydrogen...
Natural products could play an important role in the challenge to discover new anti-malarial drugs. In a previous study, Dicoma tomentosa (Asteraceae) was selected for its promising anti-plasmodial activity after preliminary screening of several plants traditionally used Burkina Faso treat malaria. The aim present study further investigate properties this plant and isolate active compounds. Eight crude extracts obtained from D. whole were tested vitro against two Plasmodium falciparum...
The in vitro antiplasmodial activities of 69 alkaloids from various Strychnos species were evaluated against chloroquine-resistant and chloroquine-sensitive lines Plasmodium falciparum. compounds, comprising mainly indolomonoterpenoid alkaloids, exhibited a wide range biological potencies the assays. most active also tested for cytotoxicity HCT-116 colon cancer cells to determine their selectivity. As result these studies, structure−activity relationships have begun emerge. Alkaloids...
"Omics" sciences have been developed to provide a holistic point of view biology and better understand the complexity an organism as whole. These systems approaches can be examined at different levels, starting from most fundamental, i.e., genome, finishing with functional, metabolome. Similar how genomics is applied exploration DNA, metabolomics qualitative quantitative study metabolites. This emerging field clearly linked genomics, transcriptomics, proteomics. In addition, provides unique...
To explore the in-vitro and in-vivo antimalarial potential of caffeic acid derivatives.Two common phenolic acids (caffeic chlorogenic acid) were evaluated for antiplasmodial activity in comparison with some semi-synthetic derivatives that synthesized. An assay based on plasmodial lactate dehydrogenase activity, classical 5-day suppressive test from Peters an artemisinin-resistant Plasmodium berghei strain was used. Parasitic stage sensitivity to ethyl caffeate determined this work.Phenolic...