A5075421164- Alkaloids: synthesis and pharmacology
- Crystallization and Solubility Studies
- Traditional and Medicinal Uses of Annonaceae
- Chemical synthesis and alkaloids
- Plant and Fungal Species Descriptions
- Plant biochemistry and biosynthesis
- Microbial Metabolic Engineering and Bioproduction
- Pharmacological Effects of Natural Compounds
- X-ray Diffraction in Crystallography
- Phytochemical Studies and Bioactivities
- Berberine and alkaloids research
- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Plant-based Medicinal Research
Institut de Chimie des Substances Naturelles
2023-2024
Université Paris-Saclay
2023-2024
Centre National de la Recherche Scientifique
2023-2024
Laboratoire des Biomolécules
2024
Chemical investigation of the emblematic Catharanthus roseus led to discovery trirosaline (1), first example a tris-ajmalicine-type monoterpene indole alkaloid and natural trimeric MIA ever reported from this deeply dug plant species. Its structure was primarily elucidated based on NMR HRESIMS analyses, nature its unique intermonomeric linkages firmly confirmed combination empirical computation ML-J-DP4 study. absolute configuration mitigated by comparison experimental TDDFT-simulated...
Plant-specialized metabolism represents an inexhaustible source of active molecules, some which have been used in human health for decades. Among these, monoterpene indole alkaloids (MIAs) include a wide range valuable compounds with anticancer, antihypertensive, or neuroactive properties. This is particularly the case pachysiphine derivatives show interesting antitumor and anti-Alzheimer activities but accumulate at very low levels several Tabernaemontana species. Unfortunately, genome data...
Abstract Plant specialized metabolism represents an inexhaustible source of active molecules, some which have been used in human health for decades. Among these, monoterpene indole alkaloids (MIAs) include a wide range valuable compounds with anticancer, antihypertensive, or neuroactive properties. This is particularly the case pachysiphine derivatives show interesting antitumor and anti-alzheimer activities but accumulate at very low levels several Tabernaemontana species. Unfortunately,...
The structure and complete NMR assignments of aspidoreticulofractine, an aspidofractinine N-oxide, are reported. Its was elucidated based on a combination spectroscopic techniques including 1D 2D NMR, high-resolution mass spectrometry, electronic circular dichroism.