A5044003341- Plant nutrient uptake and metabolism
- Alkaloids: synthesis and pharmacology
- Legume Nitrogen Fixing Symbiosis
- Plant Molecular Biology Research
- Plant responses to water stress
- Natural product bioactivities and synthesis
- Plant tissue culture and regeneration
- Berberine and alkaloids research
- Photosynthetic Processes and Mechanisms
- CRISPR and Genetic Engineering
- Insect symbiosis and bacterial influences
- Metabolism, Diabetes, and Cancer
- Polymer-Based Agricultural Enhancements
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Plant Micronutrient Interactions and Effects
- Plant Diversity and Evolution
- Phytochemical Studies and Bioactivities
- Microbial Natural Products and Biosynthesis
- Chemical synthesis and alkaloids
- Traditional and Medicinal Uses of Annonaceae
- Plant Virus Research Studies
- Plant Stress Responses and Tolerance
- Plant-Microbe Interactions and Immunity
- Plant-based Medicinal Research
Université de Tours
2023-2025
Université de Poitiers
2013-2023
Centre National de la Recherche Scientifique
2013-2023
Écologie et Biologie des Interactions
2016-2023
Institut Jean-Pierre Bourgin
2018-2023
AgroParisTech
2022-2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2022-2023
Université Paris-Saclay
2022-2023
Source-to-sink transport of sugar is one the major determinants plant growth and relies on efficient controlled distribution sucrose (and some other sugars such as raffinose polyols) across organs through phloem. However, phloem can be affected by many environmental factors that alter source/sink relationships. In this paper, we summarize current knowledge about mechanisms review effects several abiotic (water salt stress, mineral deficiency, CO2, light, temperature, air, soil pollutants)...
Root high plasticity is an adaptation to its changing environment. Water deficit impairs growth, leading sugar accumulation in leaves, part of which could be available roots via sucrose (Suc) phloem transport. Phloem loading widely described Arabidopsis (Arabidopsis thaliana), while unloading less understood. To gain information on leaf-to-root transport, a soil-based culture system was developed monitor root architecture two dimensions. Under water (50% soil water-holding capacity), total...
The regulation of source-to-sink sucrose transport is associated with AtSUC and AtSWEET transporters' gene expression changes in plants grown hydroponically under different physiological conditions. Source-to-sink one the major determinants plant growth. Whole-plant carbohydrates' partitioning requires specific activity membrane sugar transporters. In Arabidopsis thaliana plants, two families transporters are involved transport: AtSUCs AtSWEETs. This study focused on comparison transporter...
Nitrate signaling improves plant growth under limited nitrate availability and, hence, optimal resource use for crop production. Whereas several transcriptional regulators of have been identified, including the Arabidopsis thaliana transcription factor NIN-LIKE PROTEIN7 (NLP7), additional are expected to fine-tune this pivotal physiological response. Here, we characterized NLP2 as a top-tier regulator early response gene regulatory network. interacts with NLP7 in vivo and shares key...
Abstract Monoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized metabolites mainly produced in Gentianales to cope with environmental challenges. Due their pharmacological properties, the biosynthetic modalities several MIA types have been elucidated but not that yohimbanes. Here, we combine metabolomics, proteomics, transcriptomics and genome sequencing Rauvolfia tetraphylla machine learning discover unexpected multiple actors this natural product synthesis. We...
Abstract NLP7 (NIN-LIKE-PROTEIN 7) is the major transcriptional factor responsible for primary nitrate response (PNR), but role of its homolog, NLP6, in nitrogen signaling and interplay between NLP6 remain to be elucidated. In this study, we show that, like NLP7, nuclear localization via a retention mechanism dependent, nucleocytosolic shuttling both independent each other. Compared with single mutants, nlp6nlp7 double mutant displays synergistic growth retardation phenotype nitrate. The...
ABSTRACT Monoterpene indole alkaloids (MIAs) constitute a vast group of plant natural products synthesized within the Gentianales order. MIAs possess outstanding pharmacological properties that explain their wide use in treatment human diseases. These biological activities result from complex structure originate intricated biosynthetic pathways involving several enzyme families and notably cytochrome P450s. The early steps MIA synthesis involve P450s 71 clade, which catalyse conversion...
Specialized metabolites possess diverse interesting biological activities and some cardenolides- monoterpene indole alkaloids- (MIAs) derived pharmaceuticals are currently used to treat human diseases such as cancers or hypertension. While these two families of biocompounds produced by specific subfamilies Apocynaceae, one member this medicinal plant family, the succulent tree Pachypodium lamerei Drake (also known Madagascar palm), does not produce specialized metabolites. To explore...
Plant bioactives hold immense potential in the medicine and food industry. The recent advancements omics applied deciphering specialized metabolic pathways underscore importance of high-quality genome releases wealth data metabolomics transcriptomics. While harnessing data, whether integrated or standalone, has proven successful unveiling plant natural product (PNP) biosynthetic pathways, democratization machine learning biology opens exciting new opportunities for enhancing exploration...
Plant-specialized metabolism represents an inexhaustible source of active molecules, some which have been used in human health for decades. Among these, monoterpene indole alkaloids (MIAs) include a wide range valuable compounds with anticancer, antihypertensive, or neuroactive properties. This is particularly the case pachysiphine derivatives show interesting antitumor and anti-Alzheimer activities but accumulate at very low levels several Tabernaemontana species. Unfortunately, genome data...
Abstract Plant specialized metabolism represents an inexhaustible source of active molecules, some which have been used in human health for decades. Among these, monoterpene indole alkaloids (MIAs) include a wide range valuable compounds with anticancer, antihypertensive, or neuroactive properties. This is particularly the case pachysiphine derivatives show interesting antitumor and anti-alzheimer activities but accumulate at very low levels several Tabernaemontana species. Unfortunately,...
Abstract Nitrate signaling improves plant growth under limited nitrate availability and, hence, optimal resource use for crop production. Ongoing work has identified several transcriptional regulators of signaling, including the Arabidopsis thaliana transcription factor NIN-LIKE PROTEIN 7 (NLP7), but additional likely remain to be identified. Here, we characterized NLP2 as a master upstream regulator early responses that interacts with NLP7 in vivo and shares key molecular features such...