A5047130743- Phytochemical compounds biological activities
- Synthesis and biological activity
- Natural product bioactivities and synthesis
- Natural Antidiabetic Agents Studies
- Ginger and Zingiberaceae research
- Synthesis and Biological Evaluation
- Phytochemistry and Biological Activities
- Synthesis and Characterization of Heterocyclic Compounds
- Traditional and Medicinal Uses of Annonaceae
- Click Chemistry and Applications
- Corrosion Behavior and Inhibition
- Concrete Corrosion and Durability
- Hydrogen embrittlement and corrosion behaviors in metals
- Computational Drug Discovery Methods
- Bioactive Compounds and Antitumor Agents
- Fungal Biology and Applications
- Insect Pest Control Strategies
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Cholinesterase and Neurodegenerative Diseases
- Multicomponent Synthesis of Heterocycles
- Chemical synthesis and alkaloids
- Marine Sponges and Natural Products
- Catalytic C–H Functionalization Methods
- MicroRNA in disease regulation
Universiti Sains Malaysia
2017-2025
University of Malaya
2010-2025
Padjadjaran University
2024
Hospital Universiti Sains Malaysia
2019-2023
Institut de Chimie des Substances Naturelles
2015
A series of new imidazole-phenazine derivatives were synthesized via a two-step process. The condensation 2,3-diaminophenazine and benzaldehyde proceeds with intermediate formation an aniline Schiff base, which undergoes subsequent cyclodehydrogenation in situ. structures the compounds characterized by 1D 2D NMR, FTIR HRMS. total thirteen imidazole phenazine validated for their inhibitory activity as anti-dengue agents vitro DENV2 NS2B-NS3 protease assay using fluorogenic Boc-Gly-Arg-Arg-AMC...
New phenylisoxazole quinoxalin-2-amine hybrids 5a–i were successfully synthesised with yields of 53–85% and characterised various spectroscopy methods.
Aglaia pachyphylla is a species from the genus (Meliaceae) and chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (1), along with four known compounds (2-5) were isolated Miq. Furthermore, structure of compound was elucidated by interpretation spectroscopic data, including 1D 2D-NMR, as well ECD NMR calculations (DP4+ analysis). Compounds 1-5 showed cytotoxic activities against MCF-7 IC50 values ranging 160.74 to 299.75 μM.
Kingianins are complex pentacyclic natural products isolated from the bark of Endiandra kingiana. This article reviews synthetic routes for kingianins and their analogues. The reports five research groups grouped in biomimetic non-biomimetic approaches, featuring use Diels-Alder [2+2] ketene cycloaddition reactions. most recent by Six, Azmi et al. reported utilisation [2+2]-ketene key precursors synthesis bicyclo[ 4.2.0]octanes as kingianins. demonstrates advantages chemistry synthesising...
This study aimed to synthesize a total of seven halogenated amidostilbenes 3a-3f using the Heck cross-coupling method. The synthesized stilbenes underwent further reactions with Lewis acids, such as FeCl3 and SnCl4, resulting in imines 4 indolines 5, respectively. structure all compounds was elucidated FTIR, 1D- 2D-NMR, XRD, HRMS analysis. Furthermore, mechanistic details underlying formation both were also discussed.
Three sesquiterpenoids, guaianediol (1), alismol (2), and spathulenol (3), were isolated from the n-hexane ethyl acetate extracts of stem bark Dysoxylum amooroides. The three compounds found in D. amooroides species for first time. structures identified established based on an extensive spectroscopic analysis involving HR-TOF-ESI-MS, IR, NMR data, as well a comparison with previously reported works literature. Compounds 1-3 further assessed cytotoxic effects against MCF-7 breast cancer...
The ethyl acetate fraction separated from the stembark of Sonneratia caseolaris retrieved three phenolic compounds, including quercetin-3-O-glucoside (1), quercetin (2), and 1-O-(2,4-dihydroxybenzoyl)-β-D-glucopyranose (3). For first time, compounds 1 3 were discovered genus. Data various spectroscopic techniques, mass spectroscopy one- two-dimensional NMR, used to identify their chemical structures. Antibacterial activity has also been assessed for all against Staphylococcus aureus ATCC...
ABSTRACT. Triterpenoids are a large group of secondary metabolites commonly found in plants, exhibiting high diversity both structural features and biological activities. Meliaceae family is knows as rich source the triterpenoid compounds. As most extensive genus within family, Aglaia known to contain many bioactive compounds, including cytotoxic triterpenoids. Among various types triterpenoids, dammarane frequently has demonstrated potential activity. This purpose research was isolate...
MicroRNAs (miRNAs) are short non-coding RNAs that regulate genes posttranscriptionally.Past studies have reported miR-210 is up-regulated in many cancers including cervical cancer, and plays a pleiotropic role carcinogenesis.However, its regulating response towards anti-cancer agents has not been fully elucidated.We previously the natural compound 1'S-1'-acetoxychavicol acetate (ACA) able to induce cytotoxicity various cancer cells cells.Hence, this study aims investigate mechanistic of ACA...
Oral cancers although preventable, possess a low five-year survival rate which has remained unchanged over the past three decades. In an attempt to find more safe, affordable and effective treatment option, we describe here use of 1'S-1'-acetoxychavicol acetate (ACA), component Malaysian ginger traditionally used for various medicinal purposes.Whether ACA can inhibit growth oral squamous cell carcinoma (SCC) cells alone or in combination with cisplatin (CDDP), was explored both vitro using...
Background: Cervical cancer is the fourth most frequent malignancy affecting women worldwide, but drug resistance and toxicities remain a major challenge in chemotherapy. The use of natural compounds promising because they are less toxic able to target multiple signaling pathways. 1'S-1'-acetoxychavicol acetate (ACA), compound isolated from wild ginger Alpinia conchigera , induced cytotoxicity on various cells including cervical cancer. MicroRNAs (miRNAs) short noncoding RNAs that regulate...
A new limonoid, pentandricine (1), along with three known limonoids, ceramicine B (2), 6-de(acetyloxy)-23-oxochisocheton (3), 6-de(acetyloxy)-23-oxo-7-O-deacetylchisocheton (4), have been isolated from the stembark of Chisocheton pentandrus. The chemical structures compound were elucidated on basis spectroscopic evidence. All compounds tested for their cytotoxic effects against MCF-7 breast cancer cells. Compounds 1-4 showed weak and no cytotoxicity cells IC50 values 369.84, 150.86, 208.93...