A5035373453- Essential Oils and Antimicrobial Activity
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Insect Pest Control Strategies
- Phytochemicals and Antioxidant Activities
- Papaya Research and Applications
- Computational Drug Discovery Methods
- Agricultural pest management studies
- Research on Leishmaniasis Studies
- Bee Products Chemical Analysis
- Influenza Virus Research Studies
- Aquaculture disease management and microbiota
- Food Quality and Safety Studies
- GABA and Rice Research
- Free Radicals and Antioxidants
- Insect and Pesticide Research
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plant Research
National Institutes of Biotechnology Malaysia
2019-2024
Ministry of Science, Technology and Innovation
2019
A series of new imidazole-phenazine derivatives were synthesized via a two-step process. The condensation 2,3-diaminophenazine and benzaldehyde proceeds with intermediate formation an aniline Schiff base, which undergoes subsequent cyclodehydrogenation in situ. structures the compounds characterized by 1D 2D NMR, FTIR HRMS. total thirteen imidazole phenazine validated for their inhibitory activity as anti-dengue agents vitro DENV2 NS2B-NS3 protease assay using fluorogenic Boc-Gly-Arg-Arg-AMC...
Honey is at high risk for the adulteration in global trade. Studies on authenticity of stingless bee honey from Trigona spp. necessary since market demand this product increasing, particularly Malaysia, due to its nutritional value. FTIR spectroscopy has recently been used approach a rapid and non-destructive measurement quality discriminate adulterated honey. The purpose study determine elementary content Apis honey, further investigate influence additional adulterants measured spectra...
Dengue virus (DENV) is a globally significant human pathogen that annually infects more than ∼300 million of the Earth's population. While clinically approved anti-dengue vaccine, Dengvaxia available for treating such infection, its treatment limited to those infected with DENV serotypes 3 and 4 only. However, vaccine no longer treat dengue infections following suspended use after several discoveries on side effects humans. In view this recent development, collection plant extracts in...
AbstractThe aim of this study is to assess how gamma irradiation affects the chemical profiles medicinal plants. Two different forms; methanol leaf extracts and dried leaves, three plants were investigated. Utilising FTIR, HPLC, LCMS techniques, qualitative measurement gallic acid (GA) in for both plant extract before after radiation treatment was carried out. In meantime, HPLC has been used do a quantitative analysis GA these order show percentage concentration phenolic acid. For herbs,...
According to the World Health Organisation (WHO), as of week 23 2022, there were more than 1,311 cases dengue in Malaysia, with 13 deaths reported. Furthermore, was an increase 65.7% during same period 2021. Despite cumulative incidence, is no effective antiviral drug available for treatment. This work aimed evaluate several nitro-benzylidene phenazine compounds, especially those that contain 4-hydroxy-3,5- bis ((2-(4-nitrophenyl)hydrazinylidene)-methyl)benzoate through pharmacophore queries...
Carica papaya leaf extracts from four different extraction methods (cold-water, hot-water, sonication and supercritical fluid), were characterized using physico-chemical analysis. Sonication showed the highest percentage yield of crude (6.76%) lowest fluid (1.83%). The Infrared (IR) spectrum cold-water extract demonstrated most similarity functional group to quercetin. Likewise, thermal analysis indicated that gave a quite similar Endothermic peak quercetin with obtained value which was...
Carica papaya (CP) leaf is long known for its traditional pharmacological effects against dengue virus and malaria. Therefore, CP could also be a potential solution the treatment of other infectious diseases, such as coronavirus. In this study, we evaluate effect ethanolic extract in inhibiting enzymatic activity three protein targets SARS-CoV-2 life cycle, which include 3-chymotrypsin-like protease (3CLpro), papain-like (PLpro) human transmembrane serine 2 (TMPRSS2). Results demonstrate...
Background and AimThe aim of this study is to evaluate the effects gamma radiation treatment on chemical constituents profiles three medicinal plants, namely Euodia malayana, Gnetum gnemon Khaya senegalensis at two different forms; methanol leaf extracts dried leaves respectively.Experimental ProcedureThe qualitative analysis Gallic Acid (GA) in plants for both plant extract before after have been performed using FTIR, HPLC LCMS techniques. Meanwhile, quantitative GA these has by indicate...