A5082557848- Medicinal Plant Research
- Bioactive natural compounds
- Synthesis and biological activity
- Phytochemical compounds biological activities
- Natural Antidiabetic Agents Studies
- Agricultural and Biological Research
- Natural Products and Applications
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Traditional and Medicinal Uses of Annonaceae
- Diverse Scientific Research Studies
- Natural product bioactivities and synthesis
- Computational Drug Discovery Methods
- Synthesis of Organic Compounds
- Curcumin's Biomedical Applications
- Phytoestrogen effects and research
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Synthesis and Biological Activity
- Piperaceae Chemical and Biological Studies
- Insect Pest Control Strategies
- Multicomponent Synthesis of Heterocycles
- Moringa oleifera research and applications
- Marine Sponges and Natural Products
- Tea Polyphenols and Effects
Padjadjaran University
2016-2025
Sunan Kalijaga State Islamic University Yogyakarta
2024
IPB University
2024
Sam Ratulangi University
2024
Carleton University
2024
Hasanuddin University
2024
Weatherford College
2024
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2024
University of Indonesia
2024
Universitas Jenderal Achmad Yani
2014
Seven flavonoid compounds, kaempferol (1), quercetin (2), quercetin-3-O-β-D-glucopyranoside (3), kaempferol-3-O-β-D-glucopyranoside (4), kaempferol-3-O-α-L-rhamnoside (5), quercetin-3-O-sophoroside (6) and quercetin-3-O-rutinoside (7), were isolated from the methanolic extract of leaves Kalanchoe prolifera. Compounds 1–7 for first time this plant. These compounds evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those (1) (2) showed strongest with IC50...
Functional cotton fabric incorporated with antibacterial microcapsules of lime (C. aurantifolia) essential oil (LO) was prepared. The coacervation method, employing two biopolymers alginate and gelatin as the shells, preferentially selected to produce LO microcapsules, whereas immobilization onto done using pad-dry-cure method various concentrations citric acid binder. inhibition zone functional subsequently analysed Kirby Bauer method. were produced a yield, encapsulation efficiency (EE),...
Ramie (Boehmeria nivea) has been reported to have a wide variety of secondary metabolite compounds in its vegetative organ that distinct organic activities. Regarding the chemical composition flowers, there no study considering their pharmacological effects. This research aims determine profile metabolites contained B. nivea flowers employing metabolomics approach. was designed obtain data base from five dissolved fractions ramie flower using Gas Chromatography-Mass Spectrometry (GC-MS/MS)...
Abstract Cyclopeptides are a class of organic compounds that demonstrate unique biochemical and therapeutic features, suitable for the pharmaceutical applications. Among diverse cyclopeptides, alanine‐rich cyclopeptide found to be potential. This peptides have biological properties such as antimicrobial cytotoxic properties. Alanine‐rich with their structures, in variety natural sources, including microorganisms higher plants. Several been synthesized by using some synthetic methods. Studies...
Purpose: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited treatment options, necessitating the development of safer and more effective therapies. The potential alkaloids derived from genus Erythrina as acetylcholinesterase (AChE) inhibitors being investigated to enhance acetylcholine levels in brain, which crucial for AD. objective this study identify strong inhibitory capacity against AChE favorable pharmacokinetic profiles. Materials Methods: A multi-step...
This research aims to determine the effect of BOPO and NPL on ROA in state-owned banking listed Indonesia Stock Exchange (BEI) during 2016-2023 period. The method used this is a quantitative panel data regression analysis using Eviews tool. secondary obtained from annual financial reports banks results show that simultaneously, have significant State-Owned Enterprise (BUMN) Banking Listed for period, but partially has negative ROA, while no Period.
Breast cancer remains a prevalent and challenging health issue for women globally. In the pursuit of more effective less harmful therapies, researchers have focused on natural compounds, especially phenolic compounds found in various plants fruits. This study aims to explore potency coumarin from Citrus aurantiifolia (Christm.) Swingle peel as alternative treatment breast through vitro silico studies. Three coumarins were isolated C. multiple steps column chromatograph. Their cytotoxic...
The ethyl acetate fraction separated from the stembark of Sonneratia caseolaris retrieved three phenolic compounds, including quercetin-3-O-glucoside (1), quercetin (2), and 1-O-(2,4-dihydroxybenzoyl)-β-D-glucopyranose (3). For first time, compounds 1 3 were discovered genus. Data various spectroscopic techniques, mass spectroscopy one- two-dimensional NMR, used to identify their chemical structures. Antibacterial activity has also been assessed for all against Staphylococcus aureus ATCC...
A new limonoid, pentandricine (1), along with three known limonoids, ceramicine B (2), 6-de(acetyloxy)-23-oxochisocheton (3), 6-de(acetyloxy)-23-oxo-7-O-deacetylchisocheton (4), have been isolated from the stembark of Chisocheton pentandrus. The chemical structures compound were elucidated on basis spectroscopic evidence. All compounds tested for their cytotoxic effects against MCF-7 breast cancer cells. Compounds 1-4 showed weak and no cytotoxicity cells IC50 values 369.84, 150.86, 208.93...
Four new compounds, acacetin 8-C-[<i>β</i>-D-apiofuranosyl-(1 → 2)-<i>β</i>-D-glucopyranoside] (<b>1</b>), 7-methoxyacacetin 3)-<i>β</i>-D-glucopyranoside] (<b>2</b>), 8-C-[<i>β</i>-D-glucopyranosyl-(1 (<b>3</b>), and 4‴-O-acetylacacetin 8-C-[<i>α</i>-L-rhamnopyranosyl-(1 (<b>4</b>), along with ten known compounds (<b>5</b>–<b>14</b>), were isolated from <i>Piper aduncum</i> leaves. The effects of these on lipopolysaccharide-induced expression the proinflammatory cytokines IL-12 p40, IL-6,...
Abstract Optimization of microcapsule shell to preserve Citrus aurantifolia lime oil (LOs), employing a coacervation method, and their inhibition against bacteria was conducted. Pre‐optimization the properties evaluated from three types combination; alginate/gelatin (A/G), gum arabic/gelatin (GA/G), arabic/chitosan (GA/C). The best pairs were further improved for ratios ranged 1 : 3, 3.25, 3.5, 3.75, 4. performance microcapsules based on yield, content, encapsulation efficiency, particle...
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Objective: The objective of this study was to determine the new bioactive compounds through gas chromatography–mass spectrometry analysis and cytotoxic activity two rodent tuber mutant plants against breast cancer cells (MCF-7).
 Methods: in were successfully increased by somaclonal variation using gamma rays irradiation technique. Further, cytotoxicity tested on cell line (MCF-7) performed 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide assay method.
 Results: This...
, a medical plant found in sub-Saharan Africa and the Western Ghats of India, shows promise as potential source bioactive compounds to treat cancer. In our ongoing research on folk plants, we report isolation flavonoid compound from stem bark
Background: Streptococcus sanguinis is Gram-positive bacteria that contribute to caries. Many antibacterial agents are resistant against so the discovery of new a crucial issue. Mechanism by disrupting cell wall promising target be developed. One enzymes contributing MurA enzyme. an enzyme catalyzing first step peptidoglycan biosynthesis in formation. Inhibiting effective and efficient way kill bacteria. Source bioactive compounds including agent can found natural product such as herbal...
A new antimalarial sterol, kaimanol (1), along with a known saringosterol (2) was isolated from the Indonesian Marine sponge, Xestospongia sp. The chemical structure of compound determined on basis spectroscopic evidences and by comparison to those related compounds previously reported. Isolated compounds, 1 2 were evaluated for their antiplasmodial effect against Plasmodium falciparum 3D7 strains. Compounds exhibited activity IC50 values 359 0.250 nM, respectively.
Two new dammarane-type triterpenoid fatty acid ester derivatives, 3β-oleate-20S-hydroxydammar-24-en (1) and 3β-oleate-20S,24S-epoxy-25-hydroxydammarane (2) with a known compound, such as 20S-hydroxydammar-24-en-3-on (3), were isolated from the stem bark of Aglaiaelliptica (C.DC.) Blume. The chemical structures determined by spectroscopic methods, including FTIR, NMR (one two-dimensional), HRESITOF-MS analysis, well derivatization comparison previous literature. Furthermore, synthetic analog...
Determination of ligand position in aspartic proteases by correlating tanimoto coefficient and binding affinity with root mean square deviationSandra Megantara, Maria Immaculata Iwo, Jutti Levita, Slamet Ibrahim
The emergence of antimicrobial resistance due to the widespread and inappropriate use antibiotics has now become global health challenge. Flavonoids have long been reported be a potent agent against wide range pathogenic microorganisms in vitro. Therefore, new development based on flavonoid structures could potential strategy fight antibiotic-resistant infections. This research aims screen potency flavonoids genus Erythrina as an inhibitor bacterial ATPase DNA gyrase B. From 378 being...
<title>Abstract</title> Marine macroalgae are nutraceuticals rich in nutritional profile and secondary bioactive metabolites. However, they have varied biochemical qualities due to a variety of reasons. This study aimed determine the phytochemical biological activities <italic>Caulerpa racemosa</italic>, edible green algae also known as Sea grapes. The successfully identified metabolites through metabolomic profiling untargeted by LC-HRMS well peptide. In addition, antioxidant activity...