A5085370132- Marine Sponges and Natural Products
- Natural product bioactivities and synthesis
- Eicosanoids and Hypertension Pharmacology
- Phytochemical Studies and Bioactivities
- Free Radicals and Antioxidants
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Marine Biology and Environmental Chemistry
- Phytochemistry and Bioactive Compounds
- Microbial Metabolism and Applications
- Synthesis and Biological Activity
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Natural Diterpenoids Research
- melanin and skin pigmentation
- Piperaceae Chemical and Biological Studies
- Inflammatory mediators and NSAID effects
- Seaweed-derived Bioactive Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemical compounds biological activities
- Microbial Metabolites in Food Biotechnology
- Plant biochemistry and biosynthesis
- NF-κB Signaling Pathways
- Allelopathy and phytotoxic interactions
Hanoi University of Pharmacy
2017-2024
Chungnam National University
2011-2016
Vietnam Academy of Science and Technology
2013-2015
Four new asterosaponins, astrosteriosides A–D (1–3 and 5), two known compounds, psilasteroside (4) marthasteroside B (6), were isolated from the MeOH extract of edible Vietnamese starfish Astropecten monacanthus. Their structures elucidated by chemical spectroscopic methods including FTICRMS 1D 2D NMR experiments. The effects extracts compounds on pro-inflammatory cytokines evaluated measuring production IL-12 p40, IL-6, TNF-α in LPS-stimulated bone marrow-derived dendritic cells. Compounds...
Inflammation is important in biomedical research, because it plays a key role inflammatory diseases including rheumatoid arthritis and other forms of arthritis, diabetes, heart disease, irritable bowel syndrome, Alzheimer’s Parkinson’s allergies, asthma, even cancer. In the present study, we describe inhibitory effect crude extracts steroids isolated from starfish Astropecten polyacanthus on pro-inflammatory cytokine (Interleukin-12 (IL-12) p40, interleukin-6 (IL-6), tumor necrosis factor α...
Nine new diterpenoids, termed sinumaximols A–I (1–3, 5–9, 12), together with three known compounds (4, 10, 11), were isolated from the methanol extract of soft coral Sinularia maxima. Their structures elucidated on basis extensive spectroscopic methods, including one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS). The evaluated for their inhibitory effects lipopolysaccharide (LPS)-stimulated production...
Based on our previous finding that certain cembranoid diterpenes possess selective toxicity against protozoan pathogens of tropical diseases such as Trypanosoma and Plasmodium, we have subjected a series 34 cembranes isolated from soft corals living in the Vietnamese sea to an vitro screening for anti-protozoal activity brucei rhodesiense (Tbr), T. cruzi (Tc), Leishmania donovani (Ld), Plasmodium falciparum (Pf). Twelve tested compounds displayed significant at least one parasites....
This study was designed to search for novel anti-cancer compounds from natural plants. The 70% ethanolic extract the rizhomes of Cimicifuga dahurica (Turcz.) Maxim. (Ranunculaceae) found possess significant in vitro anti-proliferative effects on MCF-7 breast cancer cells. A phytochemical investigation using assay-guided fractionation C. resulted isolation one new phenolic amide glycoside 3, two lignan glycosides 4 and 7, 9,19-cycloartane triterpenoid 6, thirteen known constituents 1, 2, 5,...
Soluble epoxide hydrolase (sEH) is essential for converting epoxy fatty acids, such as epoxyeicosatrienoic acids (EETs), into their dihydroxy forms. EETs play a crucial role in regulating blood pressure, mediating anti-inflammatory responses, and modulating pain, making sEH key target therapeutic interventions. Current research increasingly focused on identifying inhibitors from natural sources, particularly marine environments, which are rich bioactive compounds due to unique metabolic...
An unusual new phenolic component, triticumoside (1), and eight known compounds, isoorientin (2), isoscoparin (3), (2R)‐2‐ O‐β ‐D‐glucopyranosyloxy‐4,7‐dimethoxy‐2H‐1,4‐benzoxazin‐3(4H)‐one (4), adenosine (5), β ‐sitosterol (6), daucosterol (7), 6′‐ O ‐linolenoyl (8), α ‐tocopherol (9), were isolated from Triticum aestivum sprouts. The hybrid structure of 1, which is a between flavone polyoxygenated benzene, rarely found in natural sources. In addition, the effects these compounds on...
Anti-inflammatory and peroxisome proliferator-activated receptors (PPARs) transactivational effects of nine compounds (1 - 9) from the roots Sophora flavescens were evaluated using NF-κB-luciferase, reverse transcriptase polymerase chain reaction, proliferator response element (PPRE)-luciferase, GAL-4-PPAR chimera assays. Compounds 4 8 significantly inhibited TNFα-induced NF-κB transcriptional activity in HepG2 cells a dose-dependent manner, with IC₅₀ values 4.0 4.4 μM, respectively....
Using various chromatographic experiments, six asterosaponins (1−6) were isolated from the MeOH extract of Vietnamese starfish Astropecten monacanthus. The cytotoxic activities and evaluated on three human cancer cell lines, HL-60 (promyelocytic leukemia), PC-3 (prostate cancer), SNU-C5 (colorectal cancer). Relative to effects postitive control mitoxantrone, (with IC50 values ranging 0.84±0.03 3.96±0.14 µg/mL) astrosterioside D (5) 4.31±0.07 5.21±0.15 µM) exhibited potent against all tested...
In this report, we investigated the antioxidant (peroxyl radical-scavenging and reducing capacities) anti-osteoporotic activities of extracts isolated constituents (1–16) from rhizomes Kaempferia parviflora Wall. ex Baker on pre-osteoclastic RAW 264.7 cells. Compound 5 exhibited significant peroxyl capacity, with TE value 8.47 ± 0.52 µM, while compound 13 showed CUPRAC 5.66 0.26 at 10.0 µM. addition, flavonoid compounds 2, 4, 6, 8, 10, 12, terpene 15 inhibition tartrate-resistant acid...
Four new compounds, acacetin 8-C-[<i>β</i>-D-apiofuranosyl-(1 → 2)-<i>β</i>-D-glucopyranoside] (<b>1</b>), 7-methoxyacacetin 3)-<i>β</i>-D-glucopyranoside] (<b>2</b>), 8-C-[<i>β</i>-D-glucopyranosyl-(1 (<b>3</b>), and 4‴-O-acetylacacetin 8-C-[<i>α</i>-L-rhamnopyranosyl-(1 (<b>4</b>), along with ten known compounds (<b>5</b>–<b>14</b>), were isolated from <i>Piper aduncum</i> leaves. The effects of these on lipopolysaccharide-induced expression the proinflammatory cytokines IL-12 p40, IL-6,...
Using various chromatographic methods, four new steroids, astropectenols A–D (1–4), along with three known compounds (5–7) were isolated from a methanol extract of the starfish Astropecten polyacanthus. The structure elucidation was confirmed by spectroscopic including one dimensional (1D)-, 2D-NMR and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). CH2Cl2 fraction compound 7 exhibit potent cytotoxic effects against HL-60 human leukemia cells IC50 8.29 µg/mL 2.70 µM,...
Nine cembranoid diterpenes 1–9, including four new compounds, crassumols D–G (1–4), were isolated from the methanol extract of Vietnamese soft coral Lobophytum crassum. Spectroscopic methods used to elucidate structures these compounds. Compound 5 exhibited a potent inhibitory effect on tumor necrosis factor-alpha (TNFα)-induced nuclear factor-kappa B (NF-κB) transcriptional activation in HepG2 cells and significantly inhibited mRNA expression cyclooxygenase-2 (COX-2) inducible nitric oxide...
A phytochemical assay-guided fractionation of the 95% ethanol extract Cimicifuga dahurica roots afforded 29 9,19-cycloartane triterpenoid glycosides, including new cimiricasides A–F (1–6). The structures 1–6 were established using contemporary NMR methods and from HRESIMS data, sugar moiety in each case was confirmed by acid hydrolysis subsequent GC/MS analysis. Compounds 2, 4, 5, 7–9, 18, 25, showed soluble epoxide hydrolase inhibitory effects with IC50 values 0.4 ± 0.1 to 24.0 0.2 μM....
In the present study, we examined inhibitory effects of a methanolic extract, dichloromethane fraction, water layer, and polyhydroxylated sterols (1–4) isolated from Vietnamese starfish Protoreaster nodosus on pro-inflammatory cytokine (IL-12 p40, IL-6, TNF-α) production in LPS-stimulated bone marrow-derived dendritic cells (BMDCs) using enzyme-linked immunosorbent assays (ELISA). The extract fraction exerted potent all three cytokines, with IC50 values ranging 0.60 ± 0.01 to 26.19 0.64...