Fahrul Nurkolis

ORCID: 0000-0003-2151-0854
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About
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Research Areas
  • Seaweed-derived Bioactive Compounds
  • Protein Hydrolysis and Bioactive Peptides
  • Food and Agricultural Sciences
  • Algal biology and biofuel production
  • Child Nutrition and Water Access
  • Phytoestrogen effects and research
  • Food Industry and Aquatic Biology
  • Phytochemicals and Antioxidant Activities
  • Natural Antidiabetic Agents Studies
  • Gut microbiota and health
  • Tea Polyphenols and Effects
  • Antioxidant Activity and Oxidative Stress
  • Medicinal Plant Research
  • Nutrition, Genetics, and Disease
  • Moringa oleifera research and applications
  • Fatty Acid Research and Health
  • Biochemical effects in animals
  • Diet and metabolism studies
  • Medicinal Plants and Neuroprotection
  • Metabolomics and Mass Spectrometry Studies
  • Diet, Metabolism, and Disease
  • Aquaculture Nutrition and Growth
  • Nutrition and Health in Aging
  • Microbial Metabolites in Food Biotechnology
  • Public Health and Nutrition

Sunan Kalijaga State Islamic University Yogyakarta
2021-2025

Airlangga University
2025

Sam Ratulangi University
2022-2024

Carleton University
2024

IPB University
2024

Hasanuddin University
2024

Weatherford College
2024

Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2024

University of Indonesia
2024

Padjadjaran University
2024

Green alga Caulerpa racemosa is an underexploited species of macroalgae, even though it characterized by a green color that indicates abundance bioactive pigments, such as chlorophyll and possibly xanthophyll. Unlike chlorophyll, which has been well explored, the composition carotenoids C. its biological activities have not reported. Therefore, this study aims to look at carotenoid profile racemose determine their activities, include antidiabetic, anti-obesity, anti-oxidative,...

10.3390/molecules28073267 article EN cc-by Molecules 2023-04-06

Marine algae have excellent bioresource properties with potential nutritional and bioactive therapeutic benefits, but studies regarding Caulerpa lentillifera are limited. This study aims to explore the metabolites profile antioxidant, anticancer, anti-obesity, in vitro cytotoxicity of fractionated ethanolic extract C. using two maceration soxhlet extraction methods. Dried simplicia was mashed extracted ethanol solvent, concentrated evaporated, then sequentially partitioned equal volumes...

10.3390/molecules28031365 article EN cc-by Molecules 2023-01-31

Abstract Hypertension, or high blood pressure (BP), is a complex disease influenced by various risk factors. It characterized persistent elevation of BP levels, typically exceeding 140/90 mmHg. Endothelial dysfunction and reduced nitric oxide (NO) bioavailability play crucial roles in hypertension development. L‐NG‐nitro arginine methyl ester (L‐NAME), an analog L‐arginine, inhibits endothelial NO synthase (eNOS) enzymes, leading to decreased production increased BP. Animal models exposed...

10.1002/ptr.8199 article EN Phytotherapy Research 2024-04-14

Clitoria ternatea, with an alternative name, Butterfly pea, is increasingly being explored for medical purposes and the development of a wide range processed products. This study aimed to incorporate pea into innovative probiotic drink through symbiotic culture bacteria yeast (SCOBY) fermentation evaluate biological activity. The benefits drink, referred as butterfly flower kombucha (KBPF) was determined in vitro metabolically disorder mice that receive diet rich cholesterol fat (CFED)....

10.1016/j.crfs.2022.08.005 article EN cc-by-nc-nd Current Research in Food Science 2022-01-01

This study evaluated the effects of an aqueous extract Caulerpa racemosa (AEC) on cardiometabolic syndrome markers, and modulation gut microbiome in mice administered a cholesterol- fat-enriched diet (CFED). Four groups received different treatments: normal diet, CFED, CFED added with AEC at 65 130 mg/kg body weight (BW). The effective concentration (EC50) values for 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), lipase inhibition were...

10.3390/nu15040909 article EN Nutrients 2023-02-11

This study wants to investigate the effects of kombucha tea based on seagrapes blood glucose levels, total cholesterol, and PGC-1α in Swiss albino mice that were given cholesterol-and fat-enriched diets (CFED).Antiglycation, tyrosinase inhibitory, α-glucosidase inhibitory activity also determined.Forty male swiss webster weighing between 20 g-30 g used for this study.Animals distributed random into 4 groups 10 animals each; group A served as normal control (received standard dry pellet...

10.1016/j.heliyon.2021.e07944 article EN cc-by-nc-nd Heliyon 2021-09-01

The prevalence of obesity is rapidly increasing and poses serious health risks accompanied by a decrease in life expectancy quality life. Therefore, the therapeutic potential natural-derived nutraceuticals against its comorbidities needs to be explored. Molecular inhibition lipase enzymes fat mass obesity-associated (FTO) protein has attracted some recent interest efforts find antiobesity agents. This study aims innovate fermented drink from Clitoria ternatea kombucha (CTK), out their...

10.1016/j.crfs.2023.100464 article EN cc-by-nc-nd Current Research in Food Science 2023-01-01

The exploration of natural ingredients to prevent or delay ageing is fascinating develop in the industrial technologies nutraceuticals. Indonesian green algae (Caulerpa racemosa and Caulerpa lentillifera) are predicted contain many bioactive substances that have not been studied intensively but potential be a source anti-ageing. Therefore, this study examine content with related proteins play an important role process vitro study. This reveals novel anti-ageing from two C. lentillifera via...

10.1016/j.jff.2023.105555 article EN cc-by-nc-nd Journal of Functional Foods 2023-04-24

Microalgae are a diverse group of microorganisms with wide range physical characteristics and interactions their surroundings. They hold great promise as strategic crops capable producing substantial quantities valuable biomolecules, such protein omega-rich oils, which have extensive applications across multiple industries. This perspective aims to provide an overview recent advancements in the utilization photobioreactors for large-scale cultivation microalgae. It also delves into...

10.1016/j.jafr.2024.101282 article EN cc-by-nc Journal of Agriculture and Food Research 2024-07-06

Green algae are natural bioresources that have excellent bioactive potential, partly due to sulfated polysaccharides (SPs) which still rarely explored for their biological activities. There is currently an urgent need studies exploring the anticancer activity of SPs extracted from two Indonesian ulvophyte green algae: polysaccharide Caulerpa racemosa (SPCr) and lentillifera (SPCl). The method isolating assessment activities in this study were based on previous similar studies. highest yield...

10.3390/molecules28114531 article EN cc-by Molecules 2023-06-02

Marine and terrestrial organisms are rich in chemical compounds with medicinal pharmacological properties, including antitumor agents for chemoprevention. Caulerpa racemosa, a marine species, is potential source of novel therapeutic human cancer. This study aimed to determine the anticancer activity C. racemosa extracts breast cancer cells, identify compounds, mechanism using computational models. Seaweed (C. racemosa) was taken from North Sulawesi, Indonesia; Followed by authentication...

10.1016/j.jafr.2023.100621 article EN cc-by-nc-nd Journal of Agriculture and Food Research 2023-05-13

Enhalus arcoides is a highly beneficial type of seagrass. Prior studies have presented proof the bioactivity E. acoroides, suggesting its potential to combat cancer. Therefore, this study aims delve deeper into acoroides bioactive molecule profiles and their direct biological anticancer activities potentials through combination in-silico in-vitro studies. This conducted metabolite profile analysis on utilizing HPLC-ESI-HRMS/MS analysis. Two extraction techniques, ethanol hexane, were...

10.3390/molecules29051082 article EN cc-by Molecules 2024-02-29

Obesity is associated with an accelerated aging process, which prevents healthy aging. Both obesity and were manifested in the peroxisome proliferator-activated receptor-γ coactivator α (PGC-1α) level. These studies fulfill scientific gap assembled pharmacological activity assay of

10.3389/fnut.2022.939073 article EN cc-by Frontiers in Nutrition 2022-07-14

To date, there has been no recent opinion that explores tempeh as a functional food can improve sports performance. Hence, this article aims to elaborate on findings the potential effect performance of soy-based tempeh. This paper presents updated evidence based literature reviews about and its relationship with The paraprobiotic role Lactobacillus gasseri for athletes found restore fatigue reduce anxiety. is achieved by increasing protein synthesis activity in eukaryotic initiation factor-2...

10.3390/nu15112599 article EN Nutrients 2023-06-01

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder with worldwide prevalence of 6–10 % women reproductive age. PCOS risk factor for cardiometabolic disorders such as type 2 diabetes, myocardial infarction, and stroke in addition to exhibiting signs hyperandrogenism anovulation. However, there no known cure PCOS, medications have only ever been used symptomatically, variety adverse effects. Drugs made from natural plant products may help treat because several extracts widely...

10.1016/j.heliyon.2023.e20889 article EN cc-by-nc-nd Heliyon 2023-10-01

Coffee became a beverage that was in demand the world and consequently produced millions of tons coffee byproducts namely silverskin (CS). Unutilized CS will be waste cause environmental pollution such as greenhouse gas emissions, landfill waste, groundwater contamination. This is research concern at this time, although many studies have been conducted to find newer applications CS, exploration its benefits health sector still limited. Therefore, exploring prevent or delay aging very...

10.3390/molecules28207037 article EN cc-by Molecules 2023-10-11
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