A new photoremovable protecting group, (6-hydroxy-3-oxo-3H-xanthen-9-yl)methyl (1), with a molar absorption coefficient ε of ∼4 × 104 m–1 cm–1 at ∼520 nm for the release carboxylates or phosphates is reported. Three derivatives 1 (diethyl phosphate, acetate, and bromide) were isolated as complexes DDQ shown to ligands quantum yields ≤2.4% in aqueous solution.

Antioksidan merupakan senyawa yang menghambat atau menunda reaksi oksidasi molekul dengan cara proses inisiasi propagasi berantai . Struktur kimiawi antioksidan, sumber radikal bebas, dan sifat fisiko-kimia sediaan sampel berbeda dapat memberikan hasil uji aktivitas antioksidan beragam. Oleh karena itu, diperlukan suatu metode analisa selektif untuk jenis tertentu. Studi perbandingan DPPH, FRAP, FIC telah dilakukan terhadap asam askorbat (AA), galat (AG), kuersetin. Ketiga dibedakan...

A functional textile immobilized by microcapsules of the lime peel essential oils C. aurantifolia (LPEO) was prepared and characterized. varied amount Chitosan/Alginate (CH/AG) ratios, followed a mass LPEO concentration sodium tripolyphosphate (STPP) crosslinker, optimized sequentially to coacervate using Tween 80 emulsifier. An antibacterial assay against both Gram-positive Gram-negative bacteria further evaluated for embedded microcapsules. The (0.2 g) effectively coacervated CH/AG (5:3)...

Functional cotton fabric incorporated with antibacterial microcapsules of lime (C. aurantifolia) essential oil (LO) was prepared. The coacervation method, employing two biopolymers alginate and gelatin as the shells, preferentially selected to produce LO microcapsules, whereas immobilization onto done using pad-dry-cure method various concentrations citric acid binder. inhibition zone functional subsequently analysed Kirby Bauer method. were produced a yield, encapsulation efficiency (EE),...

The extract of Citrus aurantifolia peel has been encapsulated into alginate-gelatin-based microbeads using an external ionotropic gelation method to apply antibacterial wound dressings. Such variables, like the alginate-gelatin ratio, quantity, and CaCl2 cross-linkers, were optimized produce a good yield, well-distributed size, encapsulation efficiency. Antibacterial efficacy was tested against both S. aureus E. coli. Optimal microbead characteristics obtained at alginate:gelatin...

Some hydantoin derivatives have been explored for their potential as anticancer agents by inhibiting receptor tyrosine kinases (RTKs). Benzalhydantoin were obtained from a two-step reaction: condensation and alkylation reaction. The benzalhydantoin activities the enzymatic assay, while molecular interaction was simulated with docking. Five known compounds (5-9) two new 10-11 synthesized appropriate precursors 4-71% yields. structures of determined mainly NMR mass spectral data. From chemical...

Although the number of COVID-19 cases is decreasing, virus continues circulating, necessitating ongoing detection efforts. This particularly important because symptoms like fever can resemble those other tropical diseases dengue fever. Lateral Flow Strip Biosensors (LFSB) offer a rapid and cost-effective testing method to address this issue. A crucial factor influencing sensitivity specificity LFSB conjugate, which consists antibody visualization agent. Anti-N-SARS-CoV-2 IgY be utilized as...

Conventional and systemic treatments of breast cancer are commonly found to expose unexpected side effects. Thus, a new drug design is intensively explored anticipate the related risks. This work aimed synthesize characterize chalcone derivatives based on cinnamaldehyde skeleton (9 - 12). Further biological assay against MCF-7 cell lines their molecular docking analysis was also performed obtain more potential chemical structure for active compounds. Four compounds...

A new promising fluorescent chemosensor based on a 2-hydroxynaphthaldehyde skeleton was successfully synthesized through double imine formation as yellow solid with an overall chemical yield of 63%. The compound showed UV/Visible maxima at 394 nm in DMSO. Based spectroscopic data FTIR, ToF-HRMS, 1H-NMR, and 13C-NMR, the product characterized 1-((Z)-((E)-(3,5-dichloro-2-hydroxybenzilydine)hydrazono)methyl)naphthalene-2-ol. Upon experimental study, confirmed highly selective reversible off-on...

A functional fabric immobilized by the microcapsules of C. aurantifolia lime essential oil (LO) was prepared and characterized.

Abstract Optimization of microcapsule shell to preserve Citrus aurantifolia lime oil (LOs), employing a coacervation method, and their inhibition against bacteria was conducted. Pre‐optimization the properties evaluated from three types combination; alginate/gelatin (A/G), gum arabic/gelatin (GA/G), arabic/chitosan (GA/C). The best pairs were further improved for ratios ranged 1 : 3, 3.25, 3.5, 3.75, 4. performance microcapsules based on yield, content, encapsulation efficiency, particle...

Abstract Nocardiotide A has been successfully synthesized using a combination of solid‐ and solution‐phase synthesis. Peptides 1 2 nocardiotide A, with different C N termini, were on 2‐chlorotrityl chloride resin. N,N,N′,N′‐ tetramethyl‐ O ‐(1 H ‐benzotriazol‐1‐yl)uronium hexafluorophosphate hydroxybenzotriazole (HBTU/HOBt) was employed as coupling reagent the release linear peptides from resin undertaken AcOH trifluoroethanol (TFE) reagents resulting in hexapeptides protected side chains...

Cyclopurpuracin is a cyclooctapeptide isolated from the methanol extract of Annona purpurea seeds with sequence cyclo-Gly-Phe-Ile-Gly-Ser-Pro-Val-Pro. In our previous study, cyclisation linear cyclopurpuracin was problematic; however, reversed version successfully cyclised even though NMR spectra revealed presence mixture conformers. Herein, we report successful synthesis using combination solid- and solution-phase synthetic methods. Initially, two precursors were prepared, precursor A...

A new onoceranoid triterpenes, namely 3-hydroxy-8,14-secogammacera-7,14-dien-21-one (1), has been isolated from the fruit peels of Lansium domesticum Corr. cv kokossan. The structure 1 was determined on basis spectroscopic data including infrared, 1D and 2D-NMR, as well high resolution mass spectroscopy analysis. Compound showed a weak activity against MCF-7 breast cancer cell lines.

Even though the COVID-19 pandemic has ended, virus is still circulating. It important to detect it, as its symptoms are similar other endemic diseases, e.g. dengue fever. Detection can be done using birds’ specific immunoglobulin Y, IgY Anti-SARS-CoV-2-Chicken Nucleocapsid (IgY anti-N), obtained by immunising chickens with SARS CoV2 nucleocapsid protein. However, purification requires further research, commonly used ligands unsuitable. Another common problem anti-N aggregation, even when...

A novel tetranortriterpenoid named kokosanolide D has been isolated from fruit peels of Lansium domesticum. The structure was elucidated primarily on the basis spectroscopic data including infrared, 1D and 2D-NMR, as well high resolution mass spectroscopy analysis comparison with related compounds previously reported.

S CAP1 is a pentapeptide isolated from the hydrolysate of oyster (Saccostrea cucullata), which has antioxidant and anticancer properties.This study aims to find novel strategy obtain peptide SCAP1 (Leu-Ala-Asn-Ala-Lys

Abstract Xylapeptide B is a cyclopentapeptide isolated from Xylaria sp. derived the Chinese medicinal plant Sophora tonkinensis . was successfully synthesized by combination of solid‐ and solution‐phase, using Fmoc strategy, 2‐chlorotrityl chloride resin. The coupling reagent used HBTU/HOBt to assist in formation amide bonds. D‐Ala chosen as C‐terminal because it has small residue can facilitate cyclization process. Linear peptide cleaved resin dilute acid concentration 20% TFA DCM no...